Matyori A, Brown CP, Ali A, Sherbeny F (2023) Statins utilization trends and expenditures in the U.S. before and after the implementation of the 2013 ACC/AHA guidelines. Saudi Pharm J 31:795–800

Article  PubMed  PubMed Central  Google Scholar 

Ward NC, Watts GF, Eckel RH (2019) Statin toxicity. Circ Res 124:328–350

Article  CAS  PubMed  Google Scholar 

Bouitbir J, Sanvee GM, Panajatovic MV, Singh F, Krahenbuhl S (2020) Mechanisms of statin-associated skeletal muscle-associated symptoms. Pharmacol Res 154:104201

Article  CAS  PubMed  Google Scholar 

Attardo S, Musumeci O, Velardo D, Toscano A (2022) Statins neuromuscular adverse effects. Int J Mol Sci 23:8364. https://doi.org/10.3390/ijms23158364

Article  PubMed  PubMed Central  Google Scholar 

Crisan E, Patil VK (2020) Neuromuscular complications of statin therapy. Curr Neurol Neurosci Rep 20:47

Article  CAS  PubMed  Google Scholar 

Taylor BA, Thompson PD (2018) Statin-associated muscle disease: advances in diagnosis and management. Neurotherapeutics 15:1006–1017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ragbourne SC, Crook MA (2015) Use of lipid-lowering medications in myasthenia gravis: a case report and literature review. J Clin Lipidol 9:256–259

Article  PubMed  Google Scholar 

Adamkova V, Vitaskova M, Hubacek JA (2024) Case report: neurological adverse events in subject with myasthenia Gravis after PCSK9 inhibitor administration. Front Cardiovasc Med 11:1343775

Article  PubMed  PubMed Central  Google Scholar 

Sugimoto T, Suzuki S, Uzawa A, Yamawaki T, Masuda M, Minami N, Kawaguchi N, Kubota T, Takahashi MP, Suzuki Y, Watanabe G, Konno S, Kimura T, Samukawa M, Ishizuchi K, Akamine H, Onishi Y, Yasuda M, Nagane Y, Maruyama H, Murai H, Utsugisawa K (2024) Worsening of myasthenic symptoms associated with statins. J Neurol Sci 464:123154

Article  CAS  PubMed  Google Scholar 

Su XW, Nandar W, Neely EB, Simmons Z, Connor JR (2016) Statins accelerate disease progression and shorten survival in SOD1(G93A) mice. Muscle Nerve 54:284–291

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Bai L, Li S, Wen Y, Liu Q, Li R, Liu Y (2021) Simvastatin enhances muscle regeneration through autophagic defect-mediated inflammation and mTOR activation in G93ASOD1 mice. Mol Neurobiol 58:1593–1606

Article  CAS  PubMed  Google Scholar 

Nijssen J, Comley LH, Hedlund E (2017) Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis. Acta Neuropathol 133:863–885

Article  PubMed  PubMed Central  Google Scholar 

Zakyrjanova GF, Giniatullin AR, Mukhutdinova KA, Kuznetsova EA, Petrov AM (2021) Early differences in membrane properties at the neuromuscular junctions of ALS model mice: effects of 25-hydroxycholesterol. Life Sci 273:119300. https://doi.org/10.1016/j.lfs.2021.119300

Article  CAS  PubMed  Google Scholar 

Mukhamedyarov MA, Khabibrakhmanov AN, Khuzakhmetova VF, Giniatullin AR, Zakirjanova GF, Zhilyakov NV, Mukhutdinova KA, Samigullin DV, Grigoryev PN, Zakharov AV, Zefirov AL, Petrov AM (2023) Early alterations in structural and functional properties in the neuromuscular junctions of mutant FUS mice. Int J Mol Sci 24:9022. https://doi.org/10.3390/ijms24109022

Article  PubMed  PubMed Central  Google Scholar 

Voermans NC, Lammens M, Wevers RA, Hermus AR, van Engelen BG (2005) Statin-disclosed acid maltase deficiency. J Intern Med 258:196–197

Article  CAS  PubMed  Google Scholar 

Vladutiu GD, Simmons Z, Isackson PJ, Tarnopolsky M, Peltier WL, Barboi AC, Sripathi N, Wortmann RL, Phillips PS (2006) Genetic risk factors associated with lipid-lowering drug-induced myopathies. Muscle Nerve 34:153–162

Article  CAS  PubMed  Google Scholar 

Falk DJ, Todd AG, Lee S, Soustek MS, ElMallah MK, Fuller DD, Notterpek L, Byrne BJ (2015) Peripheral nerve and neuromuscular junction pathology in Pompe disease. Hum Mol Genet 24:625–636

Article  CAS  PubMed  Google Scholar 

Ruano G, Windemuth A, Wu AH, Kane JP, Malloy MJ, Pullinger CR, Kocherla M, Bogaard K, Gordon BR, Holford TR, Gupta A, Seip RL, Thompson PD (2011) Mechanisms of statin-induced myalgia assessed by physiogenomic associations. Atherosclerosis 218:451–456

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghatak A, Faheem O, Thompson PD (2010) The genetics of statin-induced myopathy. Atherosclerosis 210:337–343

Article  CAS  PubMed  Google Scholar 

Tsivgoulis G, Spengos K, Karandreas N, Panas M, Kladi A, Manta P (2006) Presymptomatic neuromuscular disorders disclosed following statin treatment. Arch Intern Med 166:1519–1524

Article  CAS  PubMed  Google Scholar 

Falcetta D, Quirim S, Cocchiararo I, Chabry F, Theodore M, Stiefvater A, Lin S, Tintignac L, Ivanek R, Kinter J, Ruegg MA, Sinnreich M, Castets P (2024) CaMKIIbeta deregulation contributes to neuromuscular junction destabilization in myotonic dystrophy type I. Skelet Muscle 14:11

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bombelli F, Lispi L, Porrini SC, Giacanelli M, Terracciano C, Massa R, Petrucci A (2016) Neuromuscular transmission abnormalities in myotonic dystrophy type 1: a neurophysiological study. Clin Neurol Neurosurg 150:84–88

Article  PubMed  Google Scholar 

Molotsky E, Liu Y, Lieberman AP, Merry DE (2022) Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy. Acta Neuropathol Commun 10:97

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JY, Park KD, Kim SM, Sunwoo IN (2013) Decremental responses to repetitive nerve stimulation in x-linked bulbospinal muscular atrophy. J Clin Neurol 9:32–35

Article  PubMed  PubMed Central  Google Scholar 

Alsolaihim A, Baker SK (2020) Statins and Neuromuscular Disease. In: Statin-Associated Muscle Symptoms. pp 155–161

Zakyrjanova GF, Matigorova VA, Kuznetsova EA, Dmitrieva SA, Tyapkina OV, Tsentsevitsky AN, Andreyanova SN, Odnoshivkina JG, Shigapova RR, Mukhamedshina YO, Gogolev YV, Petrov AM (2025) Key genes and processes affected by atorvastatin treatment in mouse diaphragm muscle. Arch Toxicol 99:2877−2901. https://doi.org/10.1007/s00204-025-04056-6

Article  PubMed  Google Scholar 

Lauwers E, Goodchild R, Verstreken P (2016) Membrane lipids in presynaptic function and disease. Neuron 90:11–25

Article  CAS  PubMed  Google Scholar 

Krivoi II, Petrov AM (2019) Cholesterol and the safety factor for neuromuscular transmission. Int J Mol Sci 20:1046. https://doi.org/10.3390/ijms20051046

Article  PubMed  PubMed Central  Google Scholar 

Zakirjanova GF, Giniatullin AR, Gafurova CR, Malomouzh AI, Fedorov NS, Khaziev AN, Tsentsevitsky AN, Petrov AM (2023) Effects of cholesterol oxidase on neurotransmission and acetylcholine levels at the mice neuromuscular junctions. Arch Biochem Biophys 749:109803. https://doi.org/10.1016/j.abb.2023.109803

Article  CAS  PubMed  Google Scholar 

Rodrigues HA, Lima RF, Fonseca Mde C, Amaral EA, Martinelli PM, Naves LA, Gomez MV, Kushmerick C, Prado MA, Guatimosim C (2013) Membrane cholesterol regulates different modes of synaptic vesicle release and retrieval at the frog neuromuscular junction. Eur J Neurosci 38:2978–2987

Article  PubMed  Google Scholar 

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