Stewart-Morgan KR, Petryk N, Groth A. Chromatin replication and epigenetic cell memory. Nat Cell Biology 2020. 2020;22(4):22:361–71.

Article  CAS  Google Scholar 

Tehrani SSH, Kogan A, Mikulski P, Jansen LET. Remembering foods and foes: emerging principles of transcriptional memory. Cell Death Differ. 2023. https://doi.org/10.1038/S41418-023-01200-6

Article  PubMed  Google Scholar 

Atlasi Y, Stunnenberg HG. The interplay of epigenetic marks during stem cell differentiation and development. Nat Rev Genet. 2017;2017 18:11.

Google Scholar 

Foster SL, Hargreaves DC, Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature. 2007;447:972–8.

Article  CAS  PubMed  Google Scholar 

Mikulski P, Tehrani SSH, Kogan A, Abdul-Zani I, Shell E, James L, et al. Transcriptional memory is conferred by combined heritable maintenance and local removal of selective chromatin modifications. Nat Struct Mol Biol. 2025. https://doi.org/10.1038/s41594-025-01522-8

Article  PubMed  PubMed Central  Google Scholar 

Siwek W, Tehrani SSH, Mata JF, Jansen LET. Activation of clustered IFNγ target genes drives Cohesin-Controlled transcriptional memory. Mol Cell. 2020;80:396–e4096.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kamada R, Yang W, Zhang Y, Patel MC, Yang Y, Ouda R, et al. Interferon stimulation creates chromatin marks and establishes transcriptional memory. Proc Natl Acad Sci U S A. 2018;115:E9162–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, et al. Simple combinations of Lineage-Determining transcription factors prime cis-Regulatory elements required for macrophage and B cell identities. Mol Cell. 2010;38:576–89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moriguchi T, Yamamoto M. A regulatory network governing Gata1 and Gata2 gene transcription orchestrates erythroid lineage differentiation. Int J Hematol. 2014;100:417–24.

Article  CAS  PubMed  Google Scholar 

Bevington SL, Cauchy P, Cockerill PN. Chromatin priming elements Establish immunological memory in T cells without activating transcription. BioEssays. 2017;39:1600184.

Article  Google Scholar 

Bonifer C, Cockerill PN. Chromatin priming of genes in development: concepts, mechanisms and consequences. Exp Hematol. 2017;49:1–8.

Article  CAS  PubMed  Google Scholar 

Larsen SB, Cowley CJ, Sajjath SM, Barrows D, Yang Y, Carroll TS, et al. Establishment, maintenance, and recall of inflammatory memory. Cell Stem Cell. 2021;28:1758–e17748.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tehrani SS, Mikulski P, Abdul-Zani I, Mata JF, Siwek W, Jansen LE. STAT1 is required to Establish but not maintain interferon-γ-induced transcriptional memory. EMBO J. 2023;42.

Bevington SL, Cauchy P, Piper J, Bertrand E, Lalli N, Jarvis RC, et al. Inducible chromatin priming is associated with the establishment of immunological memory in T cells. EMBO J. 2016;35:515–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lämke J, Brzezinka K, Altmann S, Bäurle I. A hit-and‐run heat shock factor governs sustained histone methylation and transcriptional stress memory. EMBO J. 2016;35:162–75.

Article  PubMed  Google Scholar 

Hoogenkamp M, Lichtinger M, Krysinska H, Lancrin C, Clarke D, Williamson A, et al. Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program. Blood. 2009;114:299–309.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cappelluti MA, Mollica Poeta V, Valsoni S, Quarato P, Merlin S, Merelli I, et al. Durable and efficient gene Silencing in vivo by hit-and-run epigenome editing. Nat 2024. 2024;627:8003.

Google Scholar 

Bonasio R, Tu S, Reinberg D. Molecular signals of epigenetic States. Sci (1979). 2010;330:612–6.

CAS  Google Scholar 

Dean C. What holds epigenetic memory? Nat Rev Mol Cell Biol. 2017;2017 18:3.

Google Scholar 

Nashun B, Hill PW, Hajkova P. Reprogramming of cell fate: epigenetic memory and the erasure of memories past. EMBO J. 2015;34:1296–308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mattei AL, Bailly N, Meissner A. DNA methylation: a historical perspective. Trends Genet. 2022;38:676–707.

Article  CAS  PubMed  Google Scholar 

Moore LD, Le T, Fan G. DNA methylation and its basic function. Neuropsychopharmacology. 2013;38:23–38.

Article  CAS  PubMed  Google Scholar 

Slotkin RK, Martienssen R. Transposable elements and the epigenetic regulation of the genome. Nat Rev Genet. 2007;8:272–85.

Article  CAS  PubMed  Google Scholar 

Li E, Zhang Y. DNA methylation in mammals. Cold Spring Harb Perspect Biol. 2014;6:a019133.

Article  PubMed  PubMed Central  Google Scholar 

Hermann A, Gowher H, Jeltsch A. Biochemistry and biology of mammalian DNA methyltransferases. Cell Mol Life Sci. 2004;61:2571–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Avvakumov GV, Walker JR, Xue S, Li Y, Duan S, Bronner C, et al. Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1. Nature. 2008;455:822–5.

Article  CAS  PubMed  Google Scholar 

Arita K, Ariyoshi M, Tochio H, Nakamura Y, Shirakawa M. Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. Nature. 2008;455:818–21.

Article  CAS  PubMed  Google Scholar 

Wang T, Xu C, Liu Y, Fan K, Li Z, Sun X, et al. Crystal structure of the human SUV39H1 chromodomain and its recognition of histone H3K9me2/3. PLoS ONE. 2012;7:e52977.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fujita N, Watanabe S, Ichimura T, Tsuruzoe S, Shinkai Y, Tachibana M, et al. Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA Methylation-based transcriptional repression. J Biol Chem. 2003;278:24132–8.

Article  CAS  PubMed  Google Scholar 

Maeda R, Tachibana M. HP1 maintains protein stability of H3K9 methyltransferases and demethylases. EMBO Rep. 2022;23.

Zhang K, Mosch K, Fischle W, Grewal SIS. Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin. Nat Struct Mol Biol. 2008;15:381–8.

Article  CAS  PubMed  Google Scholar 

Margueron R, Reinberg D. The polycomb complex PRC2 and its mark in life. Nature. 2011;469:343–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Margueron R, Justin N, Ohno K, Sharpe ML, Son J, Drury III WJ, et al. Role of the polycomb protein EED in the propagation of repressive histone marks. Nature. 2009;461:762–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tolhuis B, Muijrers I, de Wit E, Teunissen H, Talhout W, van Steensel B, et al. Genome-wide profiling of PRC1 and PRC2 polycomb chromatin binding in drosophila melanogaster. Nat Genet. 2006;38:694–9.

Article  CAS