Virchow, R. Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre: Pionierarbeit der Zellpathologie und Gewebelehre im 19. Jahrhundert. (Good Press, 1858).

Dulbecco, R., Allen, R., Okada, S. & Bowman, M. Functional changes of intermediate filaments in fibroblastic cells revealed by a monoclonal antibody. Proc. Natl Acad. Sci. USA 80, 1915–1918 (1983).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang, H. Y. et al. Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc. Natl Acad. Sci. USA 99, 12877–12882 (2002).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muhl, L. et al. Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination. Nat. Commun. 11, 3953 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mor-Vaknin, N., Punturieri, A., Sitwala, K. & Markovitz, D. M. Vimentin is secreted by activated macrophages. Nat. Cell Biol. 5, 59–63 (2003).

Article  CAS  PubMed  Google Scholar 

Li, R. et al. Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response. eLife 7, e36865 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Chandrakanthan, V. et al. Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta. Nat. Cell Biol. 24, 1211–1225 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mariathasan, S. et al. TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells. Nature 554, 544–548 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krishnamurty, A. T. et al. LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Nature 611, 148 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan, D., Takawale, A., Lee, J. & Kassiri, Z. Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease. Fibrogenesis Tissue Repair 5, 15 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Friedrich, M. et al. IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies. Nat. Med. 27, 1970–1981 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rivellese, F. et al. Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial. Nat. Med. 28, 1256–1268 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, F. et al. Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. Nature 623, 616–624 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kelly, T., Huang, Y., Simms, A. E. & Mazur, A. Fibroblast activation protein-ɑ: a key modulator of the microenvironment in multiple pathologies. Int. Rev. Cell Mol. Biol. 297, 83–116 (2012).

Article  CAS  PubMed  Google Scholar 

Kiener, H. P. et al. Cadherin-11 promotes invasive behavior of fibroblast-like synoviocytes. Arthritis Rheum. 60, 1305–1310 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Roberts, E. W. et al. Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia. J. Exp. Med. 210, 1137–1151 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tran, E. et al. Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia. J. Exp. Med. 210, 1125–1135 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malhotra, D. et al. Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat. Immunol. 13, 499–510 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gravallese, E. M. & Firestein, G. S. Rheumatoid arthritis — common origins, divergent mechanisms. N. Engl. J. Med. 388, 529–542 (2023).

Article  CAS  PubMed  Google Scholar 

Aletaha, D. & Smolen, J. S. Diagnosis and management of rheumatoid arthritis: a review. JAMA 320, 1360–1372 (2018).

Article  PubMed  Google Scholar 

Smolen, J. S. & Aletaha, D. Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges. Nat. Rev. Rheumatol. 11, 276–289 (2015).

Article  PubMed  Google Scholar 

Smith, M. D. The normal synovium. Open Rheumatol. J. 5, 100–106 (2011).

Article  PubMed  PubMed Central  Google Scholar 

Hochberg, M. C. et al. Rheumatology (Elsevier, 2023).

Fletcher, A. L., Acton, S. E. & Knoblich, K. Lymph node fibroblastic reticular cells in health and disease. Nat. Rev. Immunol. 15, 350–361 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perez-Shibayama, C., Gil-Cruz, C. & Ludewig, B. Fibroblastic reticular cells at the nexus of innate and adaptive immune responses. Immunol. Rev. 289, 31–41 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, L., Wu, J., Abdi, R., Jewell, C. M. & Bromberg, J. S. Lymph node fibroblastic reticular cells steer immune responses. Trends Immunol. 42, 723–734 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Onder, L. & Ludewig, B. A fresh view on lymph node organogenesis. Trends Immunol. 39, 775–787 (2018).

Article  CAS  PubMed  Google Scholar 

van de Pavert, S. A. & Mebius, R. E. New insights into the development of lymphoid tissues. Nat. Rev. Immunol. 10, 664–674 (2010).

Article  PubMed  Google Scholar 

Katakai, T. et al. Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J. Immunol. 181, 6189–6200 (2008).

Article  CAS  PubMed  Google Scholar 

Roozendaal, R. et al. Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity 30, 264–276 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cremasco, V. et al. B cell homeostasis and follicle confines are governed by fibroblastic reticular cells. Nat. Immunol. 15, 973–981 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tew, J. G. et al. Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells. Immunol. Rev. 156, 39–52 (1997).

Article