Bayik D, Lathia JD (2021) Cancer stem cell-immune cell crosstalk in tumour progression. Nat Rev Cancer 21:526–536

CAS  PubMed  PubMed Central  Google Scholar 

Chen XX, Zhang N, Fu XF, Jiang Y, Wang MY (2020) LncRNA DBH-AS1 facilitates the tumorigenesis of melanoma by targeting miR-233-3p via IGF-1R/Akt signaling. Eur Rev Med Pharmacol Sci 24(14):7698–7708

PubMed  Google Scholar 

Gao Y, You M, Fu J, Tian M, Zhong X, Du C, Hong Z et al (2021) Intratumoral stem-like CCR4 + regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B. J Hepatol

Gordan JD, Kennedy EB, Abou-Alfa GK, Beg MS, Brower ST, Gade TP, Goff L et al (2020) Systemic therapy for advanced hepatocellular carcinoma: ASCO guideline. J Clin Oncol 38:4317–4345

CAS  PubMed  Google Scholar 

Han T, Zheng H, Zhang J, Yang P, Li H, Cheng Z, Xiang D et al (2022) Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis. Cell Death Dis 13:200

CAS  PubMed  PubMed Central  Google Scholar 

Huang X, Xu L, Ma T, Yin X, Huang Z, Ran Y, Ni Y et al (2021a) Lenvatinib plus immune checkpoint inhibitors improve survival in advanced hepatocellular carcinoma: a retrospective study. Front Oncol 11:751159

CAS  PubMed  PubMed Central  Google Scholar 

Huang J, Wang J, He H, Huang Z, Wu S, Chen C, Liu W, Xie L, Tao Y, Cong L, Jiang Y (2021b) Close interactions between LncRNAs, lipid metabolism and ferroptosis in cancer. Int J Biol Sci 17(15):4493–4513

CAS  PubMed  PubMed Central  Google Scholar 

Huang JL, Wang XK, Liao XW, Han CY, Yu TD, Huang KT, Yang CK et al (2021c) SOX4 as biomarker in hepatitis B virus-associated hepatocellular carcinoma. J Cancer 12:3486–3500

CAS  PubMed  PubMed Central  Google Scholar 

Jin H, Shi Y, Lv Y, Yuan S, Ramirez CFA, Lieftink C, Wang L et al (2021) EGFR activation limits the response of liver cancer to lenvatinib. Nature 595:730–734

CAS  PubMed  Google Scholar 

Kreso A, Dick JE (2014) Evolution of the cancer stem cell model. Cell Stem Cell 14:275–291

CAS  PubMed  Google Scholar 

Lai SA, Gundlapalli H, Ekiz HA, Jiang A, Fernandez E, Welm AL (2021) Blocking Short-Form Ron eliminates breast cancer metastases through accumulation of Stem-Like CD4(+) T cells that subvert immunosuppression. Cancer Discov

Li Y, Hu J, Guo D, Ma W, Zhang X, Zhang Z, Lu G, He S (2022) LncRNA SNHG5 promotes the proliferation and cancer stem cell-like properties of HCC by regulating UPF1 and Wnt-signaling pathway. Cancer Gene Ther 29(10):1373–1383

CAS  PubMed  PubMed Central  Google Scholar 

Lin S, Choe J, Du P, Triboulet R, Gregory RI (2016) The m(6)A methyltransferase METTL3 promotes translation in human cancer cells. Mol Cell 62:335–345

CAS  PubMed  PubMed Central  Google Scholar 

Lin ZX, Zhu LH, Huang JY, Huang YY, Lin X (2022) Paclitaxel-resistant related LncRNA DBH-AS1 promotes the proliferation and invasion of esophageal cancer. Eur Rev Med Pharmacol Sci 26(23):8903–8913

PubMed  Google Scholar 

Liu Y, Zhang C, Fan J, Xiao L, Yin B, Zhou L, Xia S (2011) Comprehensive analysis of clinical significance of stem-cell related factors in renal cell cancer. World J Surg Oncol 9:121

PubMed  PubMed Central  Google Scholar 

Liu J et al (2018) m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol 20:1074–1083

CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Yang W, Petrick JL, Liao LM, Wang W, He N, Campbell PT et al (2021) Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality. Nat Commun 12:6388

CAS  PubMed  PubMed Central  Google Scholar 

McCabe EM, Rasmussen TP (2021) LncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions. Semin Cancer Biol 75:38–48

CAS  PubMed  Google Scholar 

Oishi N, Wang XW (2011) Novel therapeutic strategies for targeting liver cancer stem cells. Int J Biol Sci 7(5):517–535

CAS  PubMed  PubMed Central  Google Scholar 

Rimini M, Kudo M, Tada T, Shigeo S, Kang W, Suda G, Jefremow A et al (2021) Nonalcoholic steatohepatitis in hepatocarcinoma: new insights about its prognostic role in patients treated with lenvatinib. ESMO Open 6:100330

CAS  PubMed  PubMed Central  Google Scholar 

Salvadori G, Zanardi F, Iannelli F, Lobefaro R, Vernieri C, Longo VD (2021) Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape. Cell Metab 33:2247–2259e2246

CAS  PubMed  PubMed Central  Google Scholar 

Sandbothe M, Buurman R, Reich N, Greiwe L, Vajen B, Gurlevik E, Schaffer V et al (2017) The microRNA-449 family inhibits TGF-beta-mediated renal cell cancer cell migration by targeting SOX4. J Hepatol 66:1012–1021

CAS  PubMed  Google Scholar 

Schwartz S et al (2014) Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5’ sites. Cell Rep 8:284–296

CAS  PubMed  PubMed Central  Google Scholar 

Shen H, Blijlevens M, Yang N, Frangou C, Wilson KE, Xu B, Zhang Y et al (2015) Sox4 expression confers bladder cancer stem cell properties and predicts for poor patient outcome. Int J Biol Sci 11:1363–1375

CAS  PubMed  PubMed Central  Google Scholar 

Siegel RL, Miller KD, Fuchs HE, Jemal A, Cancer Statistics (2021) CA Cancer J Clin 2021;71:7–33

Singh AK, Arya RK, Maheshwari S, Singh A, Meena S, Pandey P, Dormond O et al (2015) Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance. Int J Cancer 136:1991–2000

CAS  PubMed  Google Scholar 

Tang Y, Li C, Zhang YJ, Wu ZH (2021) Ferroptosis-related long non-coding RNA signature predicts the prognosis of head and neck squamous cell carcinoma. Int J Biol Sci 17(3):702–711

CAS  PubMed  PubMed Central  Google Scholar 

Venkatesh J, Wasson MD, Brown JM, Fernando W, Marcato P (2021) LncRNA-miRNA axes in breast cancer: novel points of interaction for strategic attack. Cancer Lett 509:81–88

CAS  PubMed  Google Scholar 

Wang K, Song W, Shen Y, Wang H, Fan Z (2021) LncRNA KLK8 modulates stem cell characteristics in colon cancer. Pathol Res Pract 224:153437

CAS  PubMed  Google Scholar 

Wang J, Yu H, Dong W, Zhang C, Hu M, Ma W, Jiang X et al (2023) N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells’ Properties and Lenvatinib Resistance Through WNT/beta-Catenin and Hippo Signaling Pathways. Gastroenterology

Xiang D, Cheng Z, Liu H, Wang X, Han T, Sun W, Li X et al (2017) Shp2 promotes liver cancer stem cell expansion by augmenting beta-catenin signaling and predicts chemotherapeutic response of patients. Hepatology 65:1566–1580

CAS  PubMed  Google Scholar 

Xiang DM, Sun W, Zhou T, Zhang C, Cheng Z, Li SC, Jiang W et al (2019a) Oncofetal HLF transactivates c-Jun to promote hepatocellular carcinoma development and Sorafenib resistance. Gut

Xiang DM, Sun W, Zhou T, Zhang C, Cheng Z, Li SC, Jiang W et al (2019b) Oncofetal HLF transactivates c-Jun to promote hepatocellular carcinoma development and Sorafenib resistance. Gut 68:1858–1871

CAS  PubMed  Google Scholar 

Yang ZF, Ho DW, Ng MN, Lau CK, Yu WC, Ngai P, Chu PW et al (2008) Significance of CD90 + cancer stem cells in human liver cancer. Cancer Cell 13:153–166

CAS  PubMed  Google Scholar 

Yang J, Qi M, Fei X, Wang X, Wang K (2021) LncRNA H19: A novel oncogene in multiple cancers. Int J Biol Sci 17(12):3188–3208

CAS  PubMed  PubMed Central  Google Scholar 

Yang L, Zheng S, Ge D, Xia M, Li H, Tang J (2022) LncRNA-COX2 inhibits fibroblast activation and epidural fibrosis by targeting EGR1. Int J Biol Sci 18(4):1347–1362

CAS  PubMed  PubMed Central  Google Scholar 

Yao H, Yang Z, Lou Y, Huang J, Yang P, Jiang W, Chen S (2021) miR-186 inhibits liver cancer stem cells expansion via targeting PTPN11. Front Oncol 11:632976

CAS  PubMed  PubMed Central  Google Scholar 

Ye X, Wang LP, Han C, Hu H, Ni CM, Qiao GL, Ouyang L, Ni JS (2022) Increased m6A modification of LncRNA DBH-AS1 suppresses pancreatic cancer growth and gemcitabine resistance via the miR-3163/USP44 axis. Ann Transl Med 10(6):304

CAS  PubMed  PubMed Central  Google Scholar 

Yin S, Li J, Hu C, Chen X, Yao M, Yan M, Jiang G et al (2007) CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int J Cancer 120:1444–1450

CAS