Abedi F, Razavi BM, Hosseinzadeh H (2020) A review on gentisic acid as a plantderived phenolic acid and metabolite of aspirin: comprehensive pharmacology, toxicology, and some pharmaceutical aspects. In: Phytotherapy research, vol 34, issue 4. John Wiley and Sons Ltd, pp 729–741. https://doi.org/10.1002/ptr.6573

Aboushanab SA, Shevyrin VA, Melekhin VV, Andreeva EI, Makeev OG, Kovaleva EG (2023) Cytotoxic activity and phytochemical screening of eco-friendly extracted flavonoids from Puerariamontana var. lobata (Willd.) Sanjappa & Pradeep and Trifoliumpratense L. Flowers Using HPLC-DAD-MS/HRMS. AppliedChem 3(1):119–140. https://doi.org/10.3390/appliedchem3010009

Article  CAS  Google Scholar 

Adrian Syahputra RA, Juwita NA, Astyka R, Lubis MF (2023) Andaliman (Zanthoxylumacanthopodium DC.) a herbal medicine from North Sumatera, Indonesia: phytochemical and pharmacological review. Heliyon 9(5):e16159. https://doi.org/10.1016/j.heliyon.2023.e16159

Article  CAS  PubMed  Google Scholar 

Alasalvar H, Yildirim Z (2021) Ultrasound-assisted extraction of antioxidant phenolic compounds from Lavandulaangustifolia flowers using natural deep eutectic solvents: an experimental design approach. Sustain Chem Pharm 22:100492. https://doi.org/10.1016/J.SCP.2021.100492

Article  CAS  Google Scholar 

Al-Karaki GN, Othman Y (2023) Effect of foliar application of amino acid biostimulants on growth, macronutrient, total phenol contents and antioxidant activity of soilless grown lettuce cultivars. S Afr J Bot 154:225–231. https://doi.org/10.1016/J.SAJB.2023.01.034

Article  CAS  Google Scholar 

Almatroodi SA, Alsahli MA, Aljohani ASM, Alhumaydhi FA, Babiker AY, Khan AA, Rahmani AH (2022) Potential therapeutic targets of resveratrol, a plant polyphenol, and its role in the therapy of various types of cancer. Molecules 27(9):2665. https://doi.org/10.3390/molecules27092665

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al-Momani LA, Abu-Orabi ST, Hlail HM, Alkhatib RQ, Al-Dalahmeh Y, Al-Qudah MA (2023) Anthemiscotula L. from Jordan: essential oil composition, LC-ESI-MS/MS profiling of phenolic acids-flavonoids and in vitro antioxidant activity. Arab J Chem 16(2):104470. https://doi.org/10.1016/J.ARABJC.2022.104470

Article  CAS  Google Scholar 

Al-Nemari R, Bacha AB, Al-Senaidy A, Almutairi MH, Arafah M, Al-Saran H, Abutaha N, Semlali A (2022) Cytotoxic effects of Annonasquamosa leaves against breast cancer cells via apoptotic signaling proteins. J King Saud Univ Sci 34(4):102013. https://doi.org/10.1016/J.JKSUS.2022.102013

Article  Google Scholar 

Alpat U, Nar T, Karasu S, Sagdic O (2023) Optimization of propolis extraction with natural deep eutectic solvents using central composite design. Phytochem Lett 58:49–59. https://doi.org/10.1016/J.PHYTOL.2023.09.013

Article  CAS  Google Scholar 

Al-Risheq DIM, Nasser MS, Qiblawey H, Hussein IA, Benamor A (2021) Choline chloride based natural deep eutectic solvent for destabilization and separation of stable colloidal dispersions. Sep Purif Technol 255:117737. https://doi.org/10.1016/j.seppur.2020.117737

Article  CAS  Google Scholar 

Asem N, Abdul Gapar NA, Abd Hapit NH, Omar EA (2020) Correlation between total phenolic and flavonoid contents with antioxidant activity of Malaysian stingless bee propolis extract. J Apic Res 59(4):437–442. https://doi.org/10.1080/00218839.2019.1684050

Article  Google Scholar 

Avilés-Betanzos KA, Cauich-Rodríguez JV, González-Ávila M, Scampicchio M, Morozova K, Ramírez-Sucre MO, Rodríguez-Buenfil IM (2023) Natural deep eutectic solvent optimization to obtain an extract rich in polyphenols from capsicum Chinense leaves using an ultrasonic probe. Processes 11(6):1729. https://doi.org/10.3390/pr11061729

Article  CAS  Google Scholar 

Bertolo MRV, Martins VCA, Plepis AMG, Bogusz S (2021) Utilization of pomegranate peel waste: natural deep eutectic solvents as a green strategy to recover valuable phenolic compounds. J Clean Prod 327:129471. https://doi.org/10.1016/J.JCLEPRO.2021.129471

Article  CAS  Google Scholar 

Bhosale PB, Ha SE, Vetrivel P, Kim HH, Kim SM, Kim GS (2020) Functions of polyphenols and its anticancer properties in biomedical research: a narrative review. Transl Cancer Res 9(12):7619. https://doi.org/10.21037/tcr-20-2359

Article  CAS  PubMed  PubMed Central  Google Scholar 

BİLDİK F (2021) Application of choline chloride as natural deep eutectic solvents for the green extraction of phenolic compounds from Rheumribes leaves. Eur J Tech. https://doi.org/10.36222/ejt.960412

Article  Google Scholar 

Boonpawa R, Spenkelink A, Punt A, Rietjens IMCM (2017) In vitro-in silico-based analysis of the dose-dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans. Br J Pharmacol 174(16):2739–2757. https://doi.org/10.1111/bph.13900

Busato M, Mannucci G, Lisio VD, Martinelli A, Giudice AD, Tofoni A, Bosco CD, Migliorati V, Gentili A, D’Angelo P (2022) Structural study of a eutectic solvent reveals hydrophobic segregation and lack of hydrogen bonding between the components. ACS Sustain Chem Eng 10(19):6337–6345. https://doi.org/10.1021/acssuschemeng.2c00920

Article  CAS  Google Scholar 

Cai L, Wang LF, Pan JP, Mi XN, Zhang Z, Geng HJ, Wang JH, Hu SH, Zhang W, Gao Q, Wu WT, Luo HM (2016) Neuroprotective effects of methyl 3,4-dihydroxybenzoate against TBHP-induced oxidative damage in SH-SY5Y cells. Molecules 21(8). https://doi.org/10.3390/molecules21081071

Chaudhry GES, Md Akim A, Sung YY, Sifzizul TMT (2022) Cancer and apoptosis: the apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics. Front Pharmacol 13:842376. https://doi.org/10.3389/fphar.2022.842376

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chemat F, Abert-Vian M, Fabiano-Tixier AS, Strube J, Uhlenbrock L, Gunjevic V, Cravotto G (2019) Green extraction of natural products. origins, current status, and future challenges. TrAC, Trends Anal Chem 118:248–263. https://doi.org/10.1016/J.TRAC.2019.05.037

Article  CAS  Google Scholar 

Chen J (2016) The cell-cycle arrest and apoptotic functions of p53 in tumor initiation and progression. Cold Spring Harbor Perspect Med 6(3):a026104. https://doi.org/10.1101/cshperspect.a026104

Article  CAS  Google Scholar 

de Paulo Farias D, de Araújo FF, Neri-Numa IA, Pastore GM (2021) Antidiabetic potential of dietary polyphenols: a mechanistic review. Food Res Int 145:110383. https://doi.org/10.1016/j.foodres.2021.110383

Article  CAS  PubMed  Google Scholar 

Dimić D, Milenković D, Ilić J, Šmit B, Amić A, Marković Z, Dimitrić Marković J (2018) Experimental and theoretical elucidation of structural and antioxidant properties of vanillylmandelic acid and its carboxylate anion. Spectrochim Acta Part A: Mol Biomol Spectrosc 198:61–70. https://doi.org/10.1016/J.SAA.2018.02.063

Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35(4):495–516. https://doi.org/10.1080/01926230701320337

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan W, Sun L, Zhou JQ, Zhang C, Qin S, Tang Y, Liu Y, Lin SS, Yuan ST (2015) Marsdenia tenacissima extract induces G0/G1 cell cycle arrest in human esophageal carcinoma cells by inhibiting mitogen-activated protein kinase (MAPK) signaling pathway. Chin J Nat Med 13(6):428–437. https://doi.org/10.1016/S1875-5364(15)30036-4

Article  CAS  PubMed  Google Scholar 

Fitri K, Andry M, Khairani TN, Winata HS, Violenta A, Lubis N, Lubis MF (2023a) Synthesis of silver nanoparticles using ethanolic extract of Nelumbonucifera Gaertn. Leaf and its cytotoxic activity against T47D and 4T1 cell lines. Rasayan J Chem 16(1):104–110. https://doi.org/10.31788/RJC.2023.1618000

Article  CAS  Google Scholar 

Fitri K, Lubis MF, Syahputra H, Astyka R, Kaban VE (2023b) Phytochemicals analysis of Baccaureamotleyana Mull. Arg. Extracts and antiproliferation effect against PANC-1 cell through p53 and Bcl-2 expressions. Rasayan J Chem 16(3):1516–1524. https://doi.org/10.31788/RJC.2023.1638326

Article  CAS  Google Scholar 

Gano ZS, Mjalli FS, Al-Wahaibi T, Al-Wahaibi Y, AlNashef IM (2015) Extractive desulfurization of liquid fuel with FeCl3-based deep eutectic solvents: experimental design and optimization by central-composite design. Chem Eng Process 93:10–20. https://doi.org/10.1016/J.CEP.2015.04.001

Article  CAS  Google Scholar 

Ghanem A, Al-Karmalawy AA, Abd El Maksoud AI, Hanafy SM, Emara HA, Saleh RM, Elshal MF (2022) Rumexvesicarius L. extract improves the efficacy of doxorubicin in triple-negative breast cancer through inhibiting Bcl2, mTOR, JNK1 and augmenting p21 expression. Inf Med Unlocked 29:100869. https://doi.org/10.1016/J.IMU.2022.100869

Article  Google Scholar 

Giordano F, Comità S, Venneri G, Rago V, Naimo GD, De Amicis F, De Bartolo A, Tundis R, Mauro L, Panno ML (2023) Poncirustrifoliata (L.) Raf. Seed extract induces cell cycle arrest and apoptosis in the androgen receptor positive LNCaP prostate cancer cells. Int J Mol Sci 24(22):16351. https://doi.org/10.3390/ijms242216351

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greenwell M, Rahman PKSM (2015) Medicinal plants: their use in anticancer treatment. Int J Pharm Sci Res 6(10):4103–4112. https://doi.org/10.13040/IJPSR.0975-8232.6(10).4103-12

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hao J, Wang Z, Jia Y, Sun L, Fu Z, Zhao M, Li Y, Yuan N, Cong B, Zhao L, Ge G (2023) Optimization of ultrasonic-assisted extraction of flavonoids from Lactucaindica L. cv. Mengzao and their antioxidant properties. Front Nutr 10:1065662. https://doi.org/10.3389/fnut.2023.1065662

Article