United Nations. World Drug Report 2023. www.unodc.org/unodc/en/data-and-analysis/world-drug-report-2023.html (2023).

Swendsen, J. & Le Moal, M. Individual vulnerability to addiction. Ann. N. Y. Acad. Sci. 1216, 73–85 (2011).

Article  PubMed  Google Scholar 

Nestler, E. J. & Lüscher, C. The molecular basis of drug addiction: linking epigenetic to synaptic and circuit mechanisms. Neuron 102, 48–59 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morgan, D. et al. Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nat. Neurosci. 5, 169–174 (2002).

Article  CAS  PubMed  Google Scholar 

Scott, K. M. et al. Associations between subjective social status and DSM-IV mental disorders: results from the World Mental Health surveys. JAMA Psychiatry 71, 1400–1408 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Langlois, S. et al. Subjective social status, objective social status, and substance use among individuals with serious mental illnesses. Psychiatry Res. 293, 113352 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Finch, K. A., Ramo, D. E., Delucchi, K. L., Liu, H. & Prochaska, J. J. Subjective social status and substance use severity in a young adult sample. Psychol. Addict. Behav. 27, 901 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Stelly, C. E., Pomrenze, M. B., Cook, J. B. & Morikawa, H. Repeated social defeat stress enhances glutamatergic synaptic plasticity in the VTA and cocaine place conditioning. eLife 5, e15448 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Rodriguez-Arias, M. et al. Social defeat in adolescent mice increases vulnerability to alcohol consumption. Addict. Biol. 21, 87–97 (2016).

Article  CAS  PubMed  Google Scholar 

Li, R. et al. Associations of socioeconomic status and healthy lifestyle with incident early-onset and late-onset dementia: a prospective cohort study. Lancet Healthy Longev. 4, e693–e702 (2023).

Article  PubMed  Google Scholar 

Demakakos, P., Biddulph, J. P., de Oliveira, C., Tsakos, G. & Marmot, M. G. Subjective social status and mortality: the English Longitudinal Study of Ageing. Eur. J. Epidemiol. 33, 729–739 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Snyder-Mackler, N. et al. Social status alters immune regulation and response to infection in macaques. Science 354, 1041–1045 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belmi, P., Neale, M. A., Reiff, D. & Ulfe, R. The social advantage of miscalibrated individuals: the relationship between social class and overconfidence and its implications for class-based inequality. J. Personal. Soc. Psychol. 118, 254 (2020).

Article  Google Scholar 

Korous, K. M., Causadias, J. M., Bradley, R. H., Luthar, S. S. & Levy, R. A systematic overview of meta-analyses on socioeconomic status, cognitive ability, and achievement: the need to focus on specific pathways. Psychol. Rep. 125, 55–97 (2022).

Article  PubMed  Google Scholar 

Dohrenwend, B. P. et al. Socioeconomic status and psychiatric disorders: the causation-selection issue. Science 255, 946–952 (1992).

Article  CAS  PubMed  Google Scholar 

Murphy, J. M. et al. Depression and anxiety in relation to social status: a prospective epidemiologic study. Arch. Gen. Psychiatry 48, 223–229 (1991).

Article  CAS  PubMed  Google Scholar 

Teles, M. C., Dahlbom, S. J., Winberg, S. & Oliveira, R. F. Social modulation of brain monoamine levels in zebrafish. Behav. Brain Res. 253, 17–24 (2013).

Article  CAS  PubMed  Google Scholar 

Winberg, S., Nilsson, G. E. & Olsén, K. H. Social rank and brain levels of monoamines and monoamine metabolites in Arctic charr, Salvelinus alpinus (L.). J. Comp. Physiol. A 168, 241–246 (1991).

Article  Google Scholar 

Cheng, H. G. et al. Change in social rank and brain dopamine levels: findings from a novel pig model. Preprint at bioRxiv https://doi.org/10.1101/2020.08.06.239780 (2020).

Martinez, D. et al. Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers. Biol. Psychiatry 67, 275–278 (2010).

Article  CAS  PubMed  Google Scholar 

Wiers, C. E. et al. Socioeconomic status is associated with striatal dopamine D2/D3 receptors in healthy volunteers but not in cocaine abusers. Neurosci. Lett. 617, 27–31 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Juarez, B. & Han, M.-H. Diversity of dopaminergic neural circuits in response to drug exposure. Neuropsychopharmacology 41, 2424–2446 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pascoli, V., Terrier, J., Hiver, A. & Lüscher, C. Sufficiency of mesolimbic dopamine neuron stimulation for the progression to addiction. Neuron 88, 1054–1066 (2015).

Article  CAS  PubMed  Google Scholar 

Shan, Q., Hu, Y., Chen, S. & Tian, Y. Nucleus accumbens dichotomically controls social dominance in male mice. Neuropsychopharmacology 47, 776–787 (2022).

Article  CAS  PubMed  Google Scholar 

Hollis, F. et al. Mitochondrial function in the brain links anxiety with social subordination. Proc. Natl Acad. Sci. USA 112, 15486–15491 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, F. et al. Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex. Science 334, 693–697 (2011).

Article  CAS  PubMed  Google Scholar 

Zhou, T. et al. History of winning remodels thalamo-PFC circuit to reinforce social dominance. Science 357, 162–168 (2017).

Article  CAS  PubMed  Google Scholar 

Vander Weele, C. M. et al. Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli. Nature 563, 397–401 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beyer, C. E. & Steketee, J. D. Dopamine depletion in the medial prefrontal cortex induces sensitized-like behavioral and neurochemical responses to cocaine. Brain Res. 833, 133–141 (1999).

Article  CAS  PubMed  Google Scholar 

Schenk, S., Horger, B. A., Peltier, R. & Shelton, K. Supersensitivity to the reinforcing effects of cocaine following 6-hydroxydopamine lesions to the medial prefrontal cortex in rats. Brain Res. 543, 227–235 (1991).

Article  CAS  PubMed  Google Scholar 

Antinori, S. et al. Levodopa prevents the reinstatement of cocaine self‐administration in rats via potentiation of dopamine release in the medial prefrontal cortex. Addict. Biol. 23, 556–568 (2018).

Article  CAS  PubMed  Google Scholar 

Sorg, B. A., Li, N. & Wu, W.-R. Dopamine D1 receptor activation in the medial prefrontal cortex prevents the expression of cocaine sensitization. J. Pharmacol. Exp. Ther. 297, 501–508 (2001).

Article  CAS  PubMed  Google Scholar 

Lammel, S., Ion, D. I., Roeper, J. & Malenka, R. C. Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron 70, 855–862 (2011).

Article  CAS  PubMed