Activity-driven myelin sheath growth is mediated by mGluR5

Almeida, R. G. & Lyons, D. A. On myelinated axon plasticity and neuronal circuit formation and function. J. Neurosci. 37, 10023–10034 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taylor, K. R. & Monje, M. Neuron–oligodendroglial interactions in health and malignant disease. Nat. Rev. Neurosci. 24, 733–746 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pajevic, S., Plenz, D., Basser, P. J. & Fields, R. D. Oligodendrocyte-mediated myelin plasticity and its role in neural synchronization. eLife 12, e81982 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bonetto, G., Belin, D. & Káradóttir, R. T. Myelin: a gatekeeper of activity-dependent circuit plasticity? Science 374, eaba6905 (2021).

Article  PubMed  Google Scholar 

Fields, R. D. A new mechanism of nervous system plasticity: activity-dependent myelination. Nat. Rev. Neurosci. 16, 756–767 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gibson, E. M. et al. Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science 344, 1252304 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Li, J., Miramontes, T. G., Czopka, T. & Monk, K. R. Synaptic input and Ca2+ activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01553-8 (2024).

Lu, T.-Y. et al. Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice. Nat. Neurosci. 26, 1739–1750 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bacmeister, C. M. et al. Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons. Nat. Neurosci. https://doi.org/10.1038/s41593-022-01169-4 (2022).

Bacmeister, C. M. et al. Motor learning promotes remyelination via new and surviving oligodendrocytes. Nat. Neurosci. 23, 819–831 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Steadman, P. E. et al. Disruption of oligodendrogenesis impairs memory consolidation in adult mice. Neuron 105, 150–164.e6 (2020).

Article  CAS  PubMed  Google Scholar 

Marisca, R. et al. Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation. Nat. Neurosci. 23, 363–374 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mitew, S. et al. Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner. Nat. Commun. 9, 306 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Etxeberria, A. et al. Dynamic modulation of myelination in response to visual stimuli alters optic nerve conduction velocity. J. Neurosci. 36, 6937–6948 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKenzie, I. A. et al. Motor skill learning requires active central myelination. Science 346, 318–322 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gyllensten, L. & Malmfors, T. Myelinization of the optic nerve and its dependence on visual function— a quantitative investigation in mice. Development 11, 255–266 (1963).

Article  CAS  Google Scholar 

Tauber, H., Waehneldt, T. V. & Neuhoff, V. Myelination in rabbit optic nerves is accelerated by artificial eye opening. Neurosci. Lett. 16, 235–238 (1980).

Article  CAS  PubMed  Google Scholar 

Demerens, C. et al. Induction of myelination in the central nervous system by electrical activity. Proc. Natl Acad. Sci. USA 93, 9887–9892 (1996).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barres, B. A. & Raff, M. C. Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons. Nature 361, 258–260 (1993).

Article  CAS  PubMed  Google Scholar 

Mangin, J.-M., Li, P., Scafidi, J. & Gallo, V. Experience-dependent regulation of NG2 progenitors in the developing barrel cortex. Nat. Neurosci. 15, 1192–1194 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hughes, E. G., Orthmann-Murphy, J. L., Langseth, A. J. & Bergles, D. E. Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex. Nat. Neurosci. 21, 696–706 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piller, M., Werkman, I. L., Brown, R. I., Latimer, A. J. & Kucenas, S. Glutamate signaling via the AMPAR subunit GluR4 regulates oligodendrocyte progenitor cell migration in the developing spinal cord. J. Neurosci. 41, 5353–5371 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Osso, L. A., Rankin, K. A. & Chan, J. R. Experience-dependent myelination following stress is mediated by the neuropeptide dynorphin. Neuron 109, 3619–3632.e5 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Serrano-Regal, M. P. et al. Expression and function of GABA receptors in myelinating cells. Front. Cell. Neurosci. 14, 256 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geraghty, A. C. et al. Loss of adaptive myelination contributes to methotrexate chemotherapy-related cognitive impairment. Neuron 103, 250–265.e8 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, T.-J. et al. In vivo regulation of oligodendrocyte precursor cell proliferation and differentiation by the AMPA-receptor subunit GluA2. Cell Rep. 25, 852–861.e7 (2018).

Article  CAS  PubMed  Google Scholar 

Kougioumtzidou, E. et al. Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival. eLife 6, e28080 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Saab, A. S. et al. Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism. Neuron 91, 119–132 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harlow, D. E., Saul, K. E., Komuro, H. & Macklin, W. B. Myelin proteolipid protein complexes with v integrin and AMPA receptors in vivo and regulates AMPA-dependent oligodendrocyte progenitor cell migration through the modulation of cell-surface GluR2 expression. J. Neurosci. 35, 12018–12032 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gautier, H. O. B. et al. Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors. Nat. Commun. 6, 8518 (2015).

Article  CAS  PubMed  Google Scholar 

Lundgaard, I. et al. Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes. PLoS Biol. 11, e1001743 (2013).

Article  PubMed 

Comments (0)

No login
gif