Cutaneous T cell immunity

Pasparakis, M., Haase, I. & Nestle, F. O. Mechanisms regulating skin immunity and inflammation. Nat. Rev. Immunol. 14, 289–301 (2014).

Article  CAS  PubMed  Google Scholar 

Nestle, F. O., Di Meglio, P., Qin, J.-Z. & Nickoloff, B. J. Skin immune sentinels in health and disease. Nat. Rev. Immunol. 9, 679–691 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Proksch, E., Brandner, J. M. & Jensen, J.-M. The skin: an indispensable barrier. Exp. Dermatol. 17, 1063–1072 (2008).

Article  PubMed  Google Scholar 

Kupper, T. S. & Fuhlbrigge, R. C. Immune surveillance in the skin: mechanisms and clinical consequences. Nat. Rev. Immunol. 4, 211–222 (2004).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gudjonsson, J. E., Johnston, A., Dyson, M., Valdimarsson, H. & Elder, J. T. Mouse models of psoriasis. J. Invest. Dermatol. 127, 1292–1308 (2007).

Article  CAS  PubMed  Google Scholar 

Watanabe, R. et al. Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells. Sci. Transl. Med. 7, 279ra39 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Elias, P. M. et al. Origin of the corneocyte lipid envelope (CLE): observations in harlequin ichthyosis and cultured human keratinocytes. J. Invest. Dermatol. 115, 765–769 (2000).

Article  CAS  PubMed  Google Scholar 

Elias, P. M. Stratum corneum defensive functions: an integrated view. J. Invest. Dermatol. 125, 183–200 (2005).

Article  CAS  PubMed  Google Scholar 

Simmons, J. & Gallo, R. L. The central roles of keratinocytes in coordinating skin immunity. J. Invest. Dermatol. 144, 2377–2398 (2024).

Article  CAS  PubMed  Google Scholar 

Gallo, R. L. & Hooper, L. V. Epithelial antimicrobial defence of the skin and intestine. Nat. Rev. Immunol. 12, 503–516 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Köck, A. et al. Human keratinocytes are a source for tumor necrosis factor α: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J. Exp. Med. 172, 1609–1614 (1990).

Article  PubMed  Google Scholar 

Wang, G. et al. Bacteria induce skin regeneration via IL-1β signaling. Cell Host Microbe 29, 777–791 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Naik, S. et al. Inflammatory memory sensitizes skin epithelial stem cells to tissue damage. Nature 550, 475–480 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gober, M. D., Fishelevich, R., Zhao, Y., Unutmaz, D. & Gaspari, A. A. Human natural killer T cells infiltrate into the skin at elicitation sites of allergic contact dermatitis. J. Invest. Dermatol. 128, 1460–1469 (2008).

Article  CAS  PubMed  Google Scholar 

Constantinides, M. G. et al. MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Science 366, eaax6624 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun, Z. et al. Skin-resident natural killer T cells participate in cutaneous allergic inflammation in atopic dermatitis. J. Allergy Clin. Immunol. 147, 1764–1777 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kobayashi, T., Ricardo-Gonzalez, R. R. & Moro, K. Skin-resident innate lymphoid cells—cutaneous innate guardians and regulators. Trends Immunol. 41, 100–112 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kashem, S. W. et al. Nociceptive sensory fibers drive interleukin-23 production from CD301b+ dermal dendritic cells and drive protective cutaneous immunity. Immunity 43, 515–526 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Filtjens, J. et al. Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection. Nat. Commun. 12, 2936 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, S. et al. Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis. Cell 184, 2151–2166 (2021).

Article  CAS  PubMed  Google Scholar 

Deng, L., Gillis, J. E., Chiu, I. M. & Kaplan, D. H. Sensory neurons: an integrated component of innate immunity. Immunity 57, 815–831 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adachi, T. et al. Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma. Nat. Med. 21, 1272–1279 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali, N. et al. Regulatory T cells in skin facilitate epithelial stem cell differentiation. Cell 169, 1119–1129 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali, N. & Rosenblum, M. D. Regulatory T cells in skin. Immunology 152, 372–381 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen, J. N. et al. Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche. Sci. Immunol. 9, eadh0152 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Makrantonaki, E., Ganceviciene, R. & Zouboulis, C. An update on the role of the sebaceous gland in the pathogenesis of acne. Dermato-Endocrinology 3, 41–49 (2011).

Article  PubMed  PubMed Central  Google Scholar 

Gallo, R. L. & Nakatsuji, T. Microbial symbiosis with the innate immune defense system of the skin. J. Invest. Dermatol. 131, 1974–1980 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shu, M. et al. Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus. PLoS ONE 8, e55380 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grice, E. A. et al. Topographical and temporal diversity of the human skin microbiome. Science 324, 1190–1192 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu, G. et al. Genus-wide comparative genomics of Malassezia delineates its phylogeny, physiology, and niche adaptation on human skin. PLoS Genet. 11, e1005614 (2015).

Article  PubMed 

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