Tonisch-klonischer Anfall unter Lamotrigin und Metamizol

Anderson GD, Gidal BE, Messenheimer JA, Gilliam FG (2002) Time course of lamotrigine de-induction: impact of step-wise withdrawal of carbamazepine or phenytoin. Epilepsy Res 49:211–217

Article  CAS  PubMed  Google Scholar 

Bachmann F, Duthaler U, Meyer zu Schwabedissen HE, Puchkov M, Huwyler J, Haschke M, Krähenbühl S (2021) Metamizole is a Moderate Cytochrome P450 Inducer via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2. Clin Pharmacol Ther 109:1505–1516

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bootsma HP, Vos AM, Hulsman J, Lambrechts D, Leenen L, Majoie M, Savelkoul M, Schellekens A, Aldenkamp AP (2008) Lamotrigine in clinical practice: long-term experience in patients with refractory epilepsy referred to a tertiary epilepsy center. Epilepsy Behav 12:262–268

Article  CAS  PubMed  Google Scholar 

Breithaupt MH, Krohmer E, Taylor L, Körner E, Hoppe-Tichy T, Burhenne J, Foerster KI, Dachtler M, Huber G, Venkatesh R, Eggenreich K, Czock D, Mikus G, Blank A, Haefeli WE (2023) Time course of CYP3A activity during and after metamizole (dipyrone) in healthy volunteers. Br J Clin Pharmacol 89:2458–2464

Article  CAS  PubMed  Google Scholar 

Gastrup S, Stage TB, Fruekilde PB, Damkier P (2016) Paracetamol decreases steady-state exposure to lamotrigine by induction of glucuronidation in healthy subjects. Br J Clin Pharmacol 81:735–741

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holtkamp M, May TW, Berkenfeld R et al (2024) Erster epileptischer Anfall und Epilepsien im Erwachsenenalter. Clin Epileptol 37:118–139. https://doi.org/10.1007/s10309-024-00663-y

Article  Google Scholar 

Lenzen-Schulte M (2024) Wie sicher ist Metamizol ? Dtsch Ärztebl 121(19):A-1234–B-1054

Google Scholar 

Lutz M (2019) Metamizole (Dipyrone) and the Liver: A Review of the Literature. J Clin Pharmacol 59:1433–1442

Article  CAS  PubMed  Google Scholar 

Miners JO, Polasek TM, Hulin JA, Rowland A, Meech R (2023) Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance. Pharmacol Ther 248:108459

Article  CAS  PubMed  Google Scholar 

Paul F, Veauthier C, Fritz G, Lehmann TN, Aktas O, Zipp F, Meencke HJ (2007) Perioperative fluctuations of lamotrigine serum levels in patients undergoing epilepsy surgery. Seizure 16:479–484

Article  PubMed  Google Scholar 

Schuck E, Ferry J, Gidal B, Hussein Z (2020) Changes in perampanel levels during de-induction: Simulations following carbamazepine discontinuation. Acta Neurol Scand 142:131–138

Article  CAS  PubMed  PubMed Central  Google Scholar 

Watermeyer F, Gaebler AJ, Neuner I, Haen E, Hiemke C, Schoretsanitis G, Paulzen M (2024) Discovering interactions in polypharmacy: Impact of metamizole on the metabolism of quetiapine. Br J Clin Pharmacol 90:2793–2801

Article  CAS  PubMed  Google Scholar 

Comments (0)

No login
gif