Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling

Danbolt NC, Storm-Mathisen J, Kanner BI (1992) An [Na+ + K+]coupled L-glutamate transporter purified from rat brain is located in glial cell processes. Neuroscience 51:295–310

Article  CAS  PubMed  Google Scholar 

Furuta A, Rothstein JD, Martin LJ (1997) Glutamate transporter protein subtypes are expressed differentially during rat CNS development. J Neurosci 17:8363–8375

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rothstein JD, Martin L, Levey AI, Dykes-Hoberg M, Jin L, Wu D, Nash N, Kuncl RW (1994) Localization of neuronal and glial glutamate transporters. Neuron 13:713–725

Article  CAS  PubMed  Google Scholar 

Sims KD, Robinson MB (1999) Expression patterns and regulation of glutamate transporters in the developing and adult nervous system. Crit Rev Neurobiol 13:169–197

Article  CAS  PubMed  Google Scholar 

Ullensvang K, Lehre KP, Storm-Mathisen J, Danbolt NC (1997) Differential developmental expression of the two rat brain glutamate transporter proteins GLAST and GLT. Eur J Neurosci 9:1646–1655

Article  CAS  PubMed  Google Scholar 

Martinez-Lozada Z, Ortega A (2023) Milestone review: excitatory amino acid transporters—beyond their expected function. J Neurochem 165:457–466

Article  CAS  PubMed  Google Scholar 

Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276:1699–1702

Article  CAS  PubMed  Google Scholar 

Pajarillo E, Rizor A, Lee J, Aschner M, Lee E (2019) The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics. Neuropharmacology 161:107559

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sheldon AL, Robinson MB (2007) The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. Neurochem Int 51:333–355

Article  CAS  PubMed  PubMed Central  Google Scholar 

Todd AC, Hardingham GE (2020) The regulation of astrocytic glutamate transporters in health and neurodegenerative diseases. Int J Mol Sci 21:9607

Article  CAS  PubMed  PubMed Central  Google Scholar 

Regan MR, Huang YH, Kim YS, Dykes-Hoberg MI, Jin L, Watkins AM, Bergles DE, Rothstein JD (2007) Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS. J Neurosci 27:6607–6619

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, Suk JS, Bergles DE, Haughey N, Pletnikov M, Hanes J, Rothstein JD (2019) Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nat Neurosci 22:741–752

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morel L, Higashimori H, Tolman M, Yang Y (2014) VGluT1+ neuronal glutamatergic signaling regulates postnatal developmental maturation of cortical protoplasmic astroglia. J Neurosci 34:10950–10962

Article  PubMed  PubMed Central  Google Scholar 

Morel L, Men Y, Chiang MSR, Tian Y, Jin S, Yelick J, Higashimori H, Yang Y (2019) Intracortical astrocyte subpopulations defined by astrocyte reporter mice in the adult brain. Glia 67:171–181

Article  PubMed  Google Scholar 

Yang Y, Vidensky S, Jin L, Jie C, Lorenzini I, Frankl M, Rothstein JD (2011) Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice. Glia 59:200–207

Article  PubMed  PubMed Central  Google Scholar 

Ghosh M, Lane M, Krizman E, Sattler R, Rothstein JD, Robinson MB (2016) The transcription factor Pax6 contributes to the induction of GLT-1 expression in astrocytes through an interaction with a distal enhancer element. J Neurochem 136:262–275

Article  CAS  PubMed  Google Scholar 

Lee ML, Martinez-Lozada Z, Krizman EN, Robinson MB (2017) Brain endothelial cells induce astrocytic expression of the glutamate transporter GLT-1 by a Notch-dependent mechanism. J Neurochem 143:489–506

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez-Lozada Z, Farmer WT, Schober AL, Krizman E, Robinson MB, Murai KK (2023) Cooperative and competitive regulation of the astrocytic transcriptome by neurons and endothelial cells: impact on astrocyte maturation. J Neurochem 167:52–75

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez-Lozada Z, Guillem AM, Robinson MB (2016) Transcriptional regulation of glutamate transporters: from extracellular signals to transcription factors. Adv Pharmacol 76:103–145

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schlag BD, Vondrasek JR, Munir M, Kalandadze A, Zelenaia OA, Rothstein JD, Robinson MB (1998) Regulation of the glial Na+-dependent glutamate transporters by cyclic AMP analogs and neurons. Mol Pharmacol 53:355–369

Article  CAS  PubMed  Google Scholar 

Zelenaia O, Schlag BD, Gochenauer GE, Ganel R, Song W, Beesley JS, Grinspan JB, Rothstein JD, Robinson MB (2000) Epidermal growth factor receptor agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on phosphatidylinositol 3-kinase and transcription factor NF-kappaB. Mol Pharmacol 57:667–678

Article  CAS  PubMed  Google Scholar 

Cameron RS, Rakic P (1991) Glial cell lineage in the cerebral cortex: a review and synthesis. Glia 4:124–137

Article  CAS  PubMed  Google Scholar 

Kriegstein A, Alvarez-Buylla A (2009) The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32:149–184

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmechel DE, Rakic P (1979) A Golgi study of radial glial cells in developing monkey telencephalon: morphogenesis and transformation into astrocytes. Anat Embryol (Berl) 156:115–152

Article  CAS  PubMed  Google Scholar 

Voigt T (1989) Development of glial cells in the cerebral wall of ferrets: direct tracing of their transformation from radial glia into astrocytes. J Comp Neurol 289:74–88

Article  CAS  PubMed  Google Scholar 

Levison SW, Goldman JE (1993) Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain. Neuron 10:201–212

Article  CAS  PubMed  Google Scholar 

Luskin MB, McDermott K (1994) Divergent lineages for oligodendrocytes and astrocytes originating in the neonatal forebrain subventricular zone. Glia 11:211–226

Article  CAS  PubMed  Google Scholar 

Zerlin M, Goldman JE (1997) Interactions between glial progenitors and blood vessels during early postnatal corticogenesis: blood vessel contact represents an early stage of astrocyte differentiation. J Comp Neurol 387:537–546

Article  CAS  PubMed  Google Scholar 

Liu J, Wu X, Lu Q (2022) Molecular divergence of mammalian astrocyte progenitor cells at early gliogenesis. Development. https://doi.org/10.1242/dev.199985

Article 

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