Issac MN, Kandasubramanian B. Effect of microplastics in water and aquatic systems. Environ Sci Pollut Res. 2021;28:19544–62.

Article  CAS  Google Scholar 

Halle AT, Jeanneau L, Martignac M, Jardé E, Pedrono B, Brach L, Gigault J. Nanoplastic in the north atlantic subtropical gyre. Environ Sci Technol. 2017;51:13689–97.

Article  PubMed  Google Scholar 

Facciolà A, Visalli G, Ciarello MP, Di Pietro A. Newly emerging airborne pollutants: current knowledge of health impact of micro and nanoplastics. Int J Environ Res Public Health. 2021;18:2997.

Article  PubMed  PubMed Central  Google Scholar 

Yang S, Zhang T, Ge Y, Cheng Y, Yin L, Pu Y, Chen Z, Liang G. Ferritinophagy mediated by oxidative stress-driven mitochondrial damage is involved in the polystyrene nanoparticles-induced ferroptosis of lung injury. ACS Nano. 2023;12:acsnano.3c07255.

Ragusa A, Svelato A, Santacroce C, Catalano P, Notarstefano V, Carnevali O, Papa F, Rongioletti MCA, Baiocco F, Draghi S, D’Amore E, Rinaldo D, Matta M, Giorgini E. Plasticenta: first evidence of microplastics in human placenta. Environ Int. 2021;146:106274.

Article  CAS  PubMed  Google Scholar 

Leslie HA, van Velzen MJM, Brandsma SH, Vethaak AD, Garcia-Vallejo JJ, Lamoree MH. Discovery and quantification of plastic particle pollution in human blood. Environ Int. 2022;163:107199.

Article  CAS  PubMed  Google Scholar 

Ragusa A, Notarstefano V, Svelato A, Belloni A, Gioacchini G, Blondeel C, Zucchelli E, De Luca C, D’Avin S, Gulotta A, Carnevali O. Giorgini. Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk. Polymers. 2022;14:2700.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Weng H, Liu S, Li F, Xu K, Wen S, Chen X, Li C, Nie Y, Liao B, Wu J, Kantawong F, Xie X, Yu F, Li G. Embryonic exposure of polystyrene nanoplastics affects cardiac development. Sci Total Environ. 2024;906:167406.

Article  CAS  PubMed  Google Scholar 

Trentacosta CJ, Davis-Kean P, Mitchell C, Hyde L. Dolinoy. Environmental contaminants and Child Development. Child Dev Perspect. 2016;10:228–33.

Article  Google Scholar 

Zhou R, Lu G, Yan Z, Jiang R, Bao X, Lu P. A review of the influences of microplastics on toxicity and transgenerational effects of pharmaceutical and personal care products in aquatic environment. Sci Total Environ. 2020;732:139222.

Article  CAS  PubMed  Google Scholar 

Tang J, Bu W, Hu W, Zhao Z, Liu L, Luo C, Wang R, Fan S, Yu S, Wu Q, Wang X, Zhao X. Ferroptosis is involved in sex-specific small intestinal toxicity in the offspring of adult mice exposed to polystyrene nanoplastics during pregnancy. ACS Nano. 2023;17:2440–9.

Article  CAS  PubMed  Google Scholar 

Kik K, Bukowska B, Sicińska P. Polystyrene nanoparticles: sources, occurrence in the environment, distribution in tissues, accumulation and toxicity to various organisms. Environ Pollut. 2020;262:114297.

Article  CAS  PubMed  Google Scholar 

Ding J, Zhang S, Razanajatovo RM, Zou H, Zhu W. Accumulation, tissue distribution, and biochemical effects of polystyrene microplastics in the freshwater fish red tilapia (Oreochromis Niloticus). Environ Pollut. 2018;238:1–9.

Article  CAS  PubMed  Google Scholar 

Che Q, Gundlach M, Yang S, Jiang J, Velki M, Yin D, Hollert H. Quantitative investigation of the mechanisms of microplastics and nanoplastics toward zebrafish larvae locomotor activity. Sci Total Environ. 2017;584–5, 1022–1031.

Jeong B, Baek JY, Koo J, Park S, Ryu Y-K, Kim K-S, Zhang S, Chung C, Dogan R, Choi H-S, Um D, Kim T-K, Lee WS, Jeong J, Shin W-H, Lee J-R, Kim N-S, Lee DY. Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny. J Hazard Mater. 2022;426:127815.

Article  CAS  PubMed  Google Scholar 

Cao JY, Dixon SJ. Mechanisms of ferroptosis. Cell Mol Life Sci. 2016;73:2195–209.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Yu C, Kang R, Tang D. Iron metabolism in ferroptosis. Front Cell Dev Biology. 2020;8:590226.

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison III B, Stockwell BR. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stockwell BR, Angeli JPF, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascon S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171:273–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Y, Lin W, Rao T, Zheng J, Zhang T, Zhang M, Lin Z. Ferroptosis and its potential role in the nervous system diseases. J Inflamm Res Volume. 2022;15:1555–74.

Article  CAS  Google Scholar 

Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509:105–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee S, Hwang N, Seok BG, Lee S, Lee S-J, Chung SW. Autophagy mediates an amplification loop during ferroptosis. Cell Death Dis. 2023;14464.

Jenner P, Dexter DT, Sian J, Schapira AHV. Marsden. Oxidative stress as a cause of nigral cell death in Parkinson’s disease and incidental lewy body disease. Ann Neurol. 1992;32:S82–87.

Article  CAS  PubMed  Google Scholar 

Levine AJ, Oren M. The first 30 years of P53: growing ever more complex. Nat Rev Cancer. 2009;9:749–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X-D, Wang Y, Wang Y, Zhang X, Han R, Wu J-C, Liang Z-Q, Gu Z-L, Han F, Fukunaga K, Qin Z-H. P53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. Autophagy. 2009;5:339–50.

Article  CAS  PubMed  Google Scholar 

Jiang L, Kon N, Li T, Wang S-J, Su T, Hibshoosh H, Baer R, Gu W. Ferroptosis as a P53-mediated activity during tumour suppression. Nature. 2015;520:57–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shin HS, Lee SH, Moon HJ, So YH, Lee HR, Lee E-H, Jung E-M. Exposure to polystyrene particles causes anxiety-, depression-like behavior and abnormal social behavior in mice. J Hazard Mater. 2023;454:131465.

Article  CAS  PubMed  Google Scholar 

Errázuriz León R, Araya Salcedo VA, Novoa San Miguel FJ, Llanquinao Tardio CRA, Tobar Briceño AA, Cherubini Fouilloux SF, de Matos Barbosa M, Barros CASaldías, Waldman WR, Espinosa-Bustos C, Hornos Carneiro MF. Photoaged polystyrene nanoplastics exposure results in reproductive toxicity due to oxidative damage in caenorhabditis elegans. Environ Pollut. 2024;348:123816.

Article  PubMed  Google Scholar 

Ya-ping Z, Lei T, Xiao-qian X, Ya-ting W, Peng L, Zhu-ge X. Effects of nanopolystyrene nanoplastic exposure on the development and neurotoxicity of fetal rats during gestation. Chin J Appl Physiol. 2022;38:760–5.

Google Scholar 

Liu X, Zhao Y, Dou J, Hou Q, Cheng J, Jiang X. Bioeffects of inhaled nanoplastics on neurons and alteration of animal behaviors through deposition in the brain. Nano Lett. 2022;22:1091–9.

Article  CAS  PubMed  Google Scholar 

Wang Z, Bi Y, Li K, Song Z, Pan C, Zhang S, Lan X, Foulkes NS, Zhao H. Nickel oxide nanoparticles induce developmental neurotoxicity in zebrafish by triggering both apoptosis and ferroptosis. Environ Science: Nano. 2023;10:640–55.

CAS  Google Scholar 

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D. Ferroptosis: process and function. Cell Death Differ. 2016;23(3):369–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Tang M. PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance. Environ Pollut. 2019;254(Pt A):112937.

Article  CAS  PubMed  Google Scholar 

Chen Q, Cao Y, Li H, Liu H, Liu Y, Bi L, Zhao H, Jin L, Peng R. Sodium nitroprusside alleviates nanoplastics