Fakhrzadeh H, Sharifi F. Cardiovascular diseases in the elderly. J Gorgan Univ Med Sci. 2012;14(3):1–9.

Google Scholar 

Khalagi K, Ansarifar A, Fahimfar N, Sanjari M, Gharibzdeh S, Sharifi F, Shafiee G, Heshmat R, Nabipour I, Larijani B, et al. Cardio-metabolic and socio-demographic risk factors associated with dependency in basic and instrumental activities of daily living among older Iranian adults: Bushehr elderly health program. BMC Geriatr. 2021;21(1):172.

Article  PubMed  PubMed Central  Google Scholar 

Singh S, Bajorek B. Defining ‘elderly’in clinical practice guidelines for pharmacotherapy. Pharm Pract 2014, 12(4).

Leritz EC, McGlinchey RE, Kellison I, Rudolph JL, Milberg WP. Cardiovascular disease risk factors and cognition in the elderly. Curr Cardiovasc risk Rep. 2011;5:407–12.

Article  PubMed  PubMed Central  Google Scholar 

Roth GA, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F, Abdela J, Abdelalim A. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the global burden of Disease Study 2017. Lancet. 2018;392(10159):1736–88.

Article  Google Scholar 

Sarrafzadegan N, Mohammmadifard N. Cardiovascular Disease in Iran in the last 40 years: Prevalence, Mortality, Morbidity, challenges and Strategies for Cardiovascular Prevention. Arch Iran Med. 2019;22(4):204–10.

PubMed  Google Scholar 

Ciumărnean L, Milaciu MV, Negrean V, Orășan OH, Vesa SC, Sălăgean O, Iluţ S, Vlaicu SI. Cardiovascular risk factors and physical activity for the prevention of cardiovascular diseases in the elderly. Int J Environ Res Public Health. 2021;19(1):207.

Article  PubMed  PubMed Central  Google Scholar 

Claesson MJ, Clooney AG, O’toole PW. A clinician’s guide to microbiome analysis. Nat Reviews Gastroenterol Hepatol. 2017;14(10):585–95.

Article  Google Scholar 

Powell N, Walker MM, Talley NJ. The mucosal immune system: master regulator of bidirectional gut–brain communications. Nat Reviews Gastroenterol Hepatol. 2017;14(3):143–59.

Article  CAS  Google Scholar 

Odenwald MA, Turner JR. The intestinal epithelial barrier: a therapeutic target? Nat Reviews Gastroenterol Hepatol. 2017;14(1):9–21.

Article  CAS  Google Scholar 

Vitetta L, Saltzman ET, Nikov T, Ibrahim I, Hall S. Modulating the gut micro-environment in the treatment of intestinal parasites. J Clin Med. 2016;5(11):102.

Article  PubMed  PubMed Central  Google Scholar 

Rosa DD, Dias MM, Grześkowiak ŁM, Reis SA, Conceição LL. Maria do Carmo GP: milk kefir: nutritional, microbiological and health benefits. Nutr Res Rev. 2017;30(1):82–96.

Article  CAS  PubMed  Google Scholar 

Xiao J, Kondo S, Takahashi N, Miyaji K, Oshida K, Hiramatsu A, Iwatsuki K, Kokubo S, Hosono A. Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. J Dairy Sci. 2003;86(7):2452–61.

Article  CAS  PubMed  Google Scholar 

Chen Y, Liu W, Xue J, Yang J, Chen X, Shao Y, Kwok L-y, Bilige M, Mang L, Zhang H. Angiotensin-converting enzyme inhibitory activity of Lactobacillus helveticus strains from traditional fermented dairy foods and antihypertensive effect of fermented milk of strain H9. J Dairy Sci. 2014;97(11):6680–92.

Article  CAS  PubMed  Google Scholar 

Pimenta FS, Luaces-Regueira M, Ton AM, Campagnaro BP, Campos-Toimil M, Pereira TM, Vasquez EC. Mechanisms of action of kefir in chronic cardiovascular and metabolic diseases. Cell Physiol Biochem. 2018;48(5):1901–14.

Article  CAS  PubMed  Google Scholar 

Kanbak G, Uzuner K, Kuşat Ol K, Oğlakçı A, Kartkaya K, Şentürk H. Effect of kefir and low-dose aspirin on arterial blood pressure measurements and renal apoptosis in unhypertensive rats with 4 weeks salt diet. Clin Exp Hypertens. 2014;36(1):1–8.

Article  CAS  PubMed  Google Scholar 

Maeda H, Zhu X, Suzuki S, Suzuki K, Kitamura S. Structural characterization and biological activities of an exopolysaccharide kefiran produced by Lactobacillus kefiranofaciens WT-2BT. J Agric Food Chem. 2004;52(17):5533–8.

Article  CAS  PubMed  Google Scholar 

Ostadrahimi A, Taghizadeh A, Mobasseri M, Farrin N, Payahoo L, Gheshlaghi ZB, Vahedjabbari M. Effect of probiotic fermented milk (kefir) on glycemic control and lipid profile in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Iran J Public Health. 2015;44(2):228.

PubMed  PubMed Central  Google Scholar 

da Silva Ghizi AC, de Almeida Silva M, de Andrade Moraes FS, da Silva CL, Endringer DC, Scherer R, Lenz D, de Lima EM, Brasil GA, Maia JF. Kefir improves blood parameters and reduces cardiovascular risks in patients with metabolic syndrome. PharmaNutrition. 2021;16:100266.

Article  Google Scholar 

Noorifard M, Moghaddam AD, Asemi Z, Farahani RH, Jazayeri SMM, Ebrahimi E. Effect of Probiotic supplementation on Oxidative Stress Enzymes and Mental Health of Athletes. Annals Military Health Sci Res 2019, 17(1).

Chen L-K, Liu L-K, Woo J, Assantachai P, Auyeung T-W, Bahyah KS, Chou M-Y, Chen L-Y, Hsu P-S, Krairit O. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc. 2014;15(2):95–101.

Article  PubMed  Google Scholar 

Al-Salami H, Butt G, Fawcett JP, Tucker IG, Golocorbin-Kon S, Mikov M. Probiotic treatment reduces blood glucose levels and increases systemic absorption of gliclazide in diabetic rats. Eur J Drug Metab Pharmacokinet. 2008;33:101–6.

Article  CAS  PubMed  Google Scholar 

Biernat E, Stupnicki R, Lebiedziński B, Janczewska L. Assessment of physical activity by applying IPAQ questionnaire. Phys Educ Sport. 2008;52(2):83–9.

Google Scholar 

Ghaffarpour M, Houshiar-Rad A, Kianfar H. The manual for household measures, cooking yields factors and edible portion of foods. Tehran: Nashre Olume Keshavarzy. 1999;7(213):42–58.

Google Scholar 

Nutritionist I. N-squared computing. Silverton: Nutritionist IV 1998.

Pereira DI, Gibson GR. Effects of consumption of probiotics and prebiotics on serum lipid levels in humans. Crit Rev Biochem Mol Biol. 2002;37(4):259–81.

Article  CAS  PubMed  Google Scholar 

Ejtahed H, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid V, Akbarian-Moghari A. Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus. J Dairy Sci. 2011;94(7):3288–94.

Article  CAS  PubMed  Google Scholar 

Sadrzadeh-Yeganeh H, Elmadfa I, Djazayery A, Jalali M, Heshmat R, Chamary M. The effects of probiotic and conventional yoghurt on lipid profile in women. Br J Nutr. 2010;103(12):1778–83.

Article  CAS  PubMed  Google Scholar 

Aller R, De Luis D, Izaola O, Conde R, Gonzalez Sagrado M, Primo D, De La Fuente B, Gonzalez J. Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial. Eur Rev Med Pharmacol Sci. 2011;15(9):1090–5.

CAS  PubMed  Google Scholar 

Firouzi S, Majid HA, Ismail A, Kamaruddin NA, Barakatun-Nisak M-Y. Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial. Eur J Nutr. 2017;56:1535–50.

Article  CAS  PubMed  Google Scholar 

Kumar M, Nagpal R, Kumar R, Hemalatha R, Verma V, Kumar A, Chakraborty C, Singh B, Marotta F, Jain S. Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. Journal of Diabetes Research 2012, 2012.

Gilliland S, Walker D. Factors to consider when selecting a culture of Lactobacillus acidophilus as a dietary adjunct to produce a hypocholesterolemic effect in humans. J Dairy Sci. 1990;73(4):905–11.

Article  CAS  PubMed  Google Scholar 

Gilliland S, Nelson C, Maxwell C. Assimilation of cholesterol by Lactobacillus acidophilus. Appl Environ Microbiol. 1985;49(2):377–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mafi A, Namazi G, Soleimani A, Bahmani F, Aghadavod E, Asemi Z. Metabolic and genetic response to probiotics supplementation in patients with diabetic nephropathy: a randomized, double-blind, placebo-controlled trial. Food Funct. 2018;9(9):4763–70.

Article  CAS  PubMed  Google Scholar 

Fathi Y, Ghodrati N, Zibaeenezhad M-J, Faghih S. Kefir drink causes a significant yet similar improvement in serum lipid profile, compared with low-fat milk, in a dairy-rich diet in overweight or obese premenopausal women: a randomized controlled trial. J Clin Lipidol. 2017;11(1):136–46.

Article  PubMed  Google Scholar 

Chan YK, El-Nezami H, Chen Y, Kinnunen K, Kirjavainen PV. Probiotic mixture VSL# 3 reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE–/– mice. Amb Express. 2016;6(1):1–8.

Article  Google Scholar 

Mortensen MB, Nordestgaard BG. Elevated LDL cholesterol and increased risk of myocardial infarction and atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort. Lancet. 2020;396(10263):1644–52.

Article  CAS  PubMed  Google Scholar 

Amarenco P, Kim JS, Labreuche J, Charles H, Abtan J, Béjot Y, Cabrejo L, Cha J-K, Ducrocq G, Giroud M. A comparison of two LDL cholesterol targets after ischemic stroke. N Engl J Med. 2020;382(1):9–19.

Article  CAS  PubMed  Google Scholar 

Ference BA, Graham I, Tokgozoglu L, Catapano AL. Impact of lipids on cardiovascular health: JACC health promotion series. J Am Coll Cardiol. 2018;72(10):1141–56.

Article  CAS  PubMed  Google Scholar 

Miremadi F, Sherkat F, Stojanovska L. Hypocholesterolaemic effect and anti-hypertensive properties of probiotics and prebiotics: a review. J Funct Foods. 2016;25:497–510.

Article  CAS  Google Scholar 

Ishimwe N, Daliri EB, Lee BH, Fang F, Du G. The perspective on cholesterol-lowering mechanisms of probiotics. Mol Nutr Food Res. 2015;59(1):94–105.

Article  CAS  PubMed