Effect of nano-curcumin supplementation on angina status, and traditional and novel cardiovascular risk factors in overweight or obese patients with coronary slow flow phenomenon: a randomized double-blind placebo-controlled clinical trial

Mohammadzad MHS, Gardeshkhah S, Khademvatani K, Sedokani A. Echocardiographic and laboratory findings in coronary slow Flow Phenomenon: cross-sectional study and review. medRxiv; 2020.

Wang X, Nie S-P. The coronary slow flow phenomenon: characteristics, mechanisms and implications. Cardiovasc Diagnosis Therapy. 2011;1(1):37–43.

Google Scholar 

Saya S, Hennebry TA, Lozano P, Lazzara R, Schechter E. Coronary slow flow phenomenon and risk for sudden cardiac death due to ventricular arrhythmias: a case report and review of literature. Clin Cardiol. 2008;31(8):352–5.

Article  PubMed  Google Scholar 

Zhu Q, Wang S, Huang X, Zhao C, Wang Y, Li X, et al. Understanding the pathogenesis of coronary slow flow: recent advances. Trends Cardiovasc Med. 2024;34(3):137–44.

Article  CAS  PubMed  Google Scholar 

Barthelmes J, Nägele MP, Ludovici V, Ruschitzka F, Sudano I, Flammer AJ. Endothelial dysfunction in cardiovascular disease and Flammer syndrome—similarities and differences. EPMA J. 2017;8(2):99–109.

Article  PubMed  PubMed Central  Google Scholar 

Ye MF, Zhao ZW, Luo YK, Dong XF, Yan YM. Elevated endocan concentration is associated with coronary slow flow. Scandinavian J Clin Lab Invest. 2016;76(5):345–8.

Article  CAS  Google Scholar 

Zhao Z-W, Ren Y-G, Liu J. Low serum adropin levels are Associated with coronary slow Flow Phenomenon. Acta Cardiol Sinica. 2018;34(4):307–12.

Google Scholar 

Riza Erbay A, Turhan H, Yasar AS, Ayaz S, Sahin O, Senen K, et al. Elevated level of plasma homocysteine in patients with slow coronary flow. Int J Cardiol. 2005;102(3):419–23.

Article  PubMed  Google Scholar 

Zhao LP, You T, Chan SP, Chen JC, Xu WT. Adropin is associated with hyperhomocysteine and coronary atherosclerosis. Experimental Therapeutic Med. 2016;11(3):1065–70.

Article  CAS  Google Scholar 

Leite AR, Borges-Canha M, Cardoso R, Neves JS, Castro-Ferreira R, Leite-Moreira A. Novel biomarkers for evaluation of endothelial dysfunction. Angiology. 2020;71(5):397–410.

Article  CAS  PubMed  Google Scholar 

Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta M, et al. Adropin is a novel regulator of endothelial function. Circulation. 2010;122(11 suppl 1):S185–92.

CAS  PubMed  Google Scholar 

Mushala BAS, Scott I. Adropin: a hepatokine modulator of vascular function and cardiac fuel metabolism. Am J Physiol Heart Circ Physiol. 2021;320(1):H238–44.

Article  CAS  PubMed  Google Scholar 

Kali A, Shetty KSR. Endocan: a novel circulating proteoglycan. Indian J Pharmacol. 2014;46(6):579–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kechagia M, Papassotiriou I, Gourgoulianis KI. Endocan and the respiratory system: a review. Int J Chron Obstruct Pulmon Dis. 2016;11:3179–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao T, Kecheng Y, Zhao X, Hu X, Zhu J, Wang Y, Ni J. The higher serum endocan levels may be a risk factor for the onset of cardiovascular disease: a meta-analysis. Medicine. 2018;97(49).

Finley J, Savage M. Coronary slow flow phenomenon: more than just an angiographic curiosity. Interventional Cardiol. 2012;4:337–47.

Article  Google Scholar 

Carrizzo A, Izzo C, Forte M, Sommella E, Di Pietro P, Venturini E et al. A Novel Promising Frontier for Human Health: the Beneficial effects of Nutraceuticals in Cardiovascular diseases. Int J Mol Sci. 2020;21(22).

Sharifi-Rad J, Rayess YE, Rizk AA, Sadaka C, Zgheib R, Zam W, et al. Turmeric and its major compound curcumin on Health: Bioactive effects and Safety profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications. Front Pharmacol. 2020;11:01021.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang C, Lu H-F, Chen Y-H, Chen J-C, Chou W-H, Huang H-C. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin induced caspase-dependent and –independent apoptosis via Smad or akt signaling pathways in HOS cells. BMC Complement Med Ther. 2020;20(1):68.

Article  PubMed  PubMed Central  Google Scholar 

Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives - a review. J Tradit Complement Med. 2017;7(2):205–33.

Article  PubMed  Google Scholar 

Stohs SJ, Chen O, Ray SD, Ji J, Bucci LR, Preuss HG. Highly bioavailable forms of Curcumin and Promising avenues for Curcumin-Based Research and Application: a review. Molecules. 2020;25(6):1397.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karimian MS, Pirro M, Johnston TP, Majeed M, Sahebkar A. Curcumin and endothelial function: evidence and mechanisms of Protective effects. Curr Pharm Des. 2017;23(17):2462–73.

Article  CAS  PubMed  Google Scholar 

Alidadi M, Liberale L, Montecucco F, Majeed M, Al-Rasadi K, Banach M, et al. Protective effects of Curcumin on Endothelium: an updated review. In: Guest PC, editor. Studies on biomarkers and new targets in Aging Research in Iran: Focus on Turmeric and Curcumin. Cham: Springer International Publishing; 2021. pp. 103–19.

Chapter  Google Scholar 

Changal KH, Khan MS, Bashir R, Sheikh MA. Curcumin preparations can improve Flow-mediated dilation and endothelial function: a Meta-analysis. Complement Med Res. 2020;27(4):272–81.

Article  PubMed  Google Scholar 

Mousavi SM, Milajerdi A, Varkaneh HK, Gorjipour MM, Esmaillzadeh A. The effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and dose-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2020;60(1):171–80.

Article  CAS  PubMed  Google Scholar 

Hewlings SJ, Kalman DS, Curcumin. A review of its effects on Human Health. Foods (Basel Switzerland). 2017;6(10):92.

PubMed  Google Scholar 

Saraf-Bank S, Ahmadi A, Paknahad Z, Maracy M, Nourian M. Effects of curcumin on cardiovascular risk factors in obese and overweight adolescent girls: a randomized clinical trial. Sao Paulo Med J. 2019;137(5):414–22.

Article  PubMed  PubMed Central  Google Scholar 

Aciksari G, Cetinkal G, Kocak M, Atici A, Celik FB, Caliskan M. The relationship between triglyceride/high-density lipoprotein cholesterol ratio and coronary slow-flow phenomenon. Int J Cardiovasc Imaging. 2022;38(1):5–13.

Article  PubMed  Google Scholar 

Indrani VS. G. Predictors of coronary slow Flow Phenomenon: a retrospective study. Indian J Cardiovasc Disease Women WINCARS. 2019;04.

Nouri-Vaskeh M, Afshan H, Malek Mahdavi A, Alizadeh L, Fan X, Zarei M. Curcumin ameliorates health-related quality of life in patients with liver cirrhosis: a randomized, double-blind placebo-controlled trial. Complement Ther Med. 2020;49:102351.

Article  PubMed  Google Scholar 

Di Ciaula A, Portincasa P, Maes N, Albert A. Efficacy of bio-optimized extracts of turmeric and essential fennel oil on the quality of life in patients with irritable bowel syndrome. Annals Gastroenterol. 2018;31(6):685–91.

Google Scholar 

Gibson CM, Cannon CP, Daley WL, Dodge JT Jr., Alexander B Jr., Marble SJ, et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation. 1996;93(5):879–88.

Article  CAS  PubMed  Google Scholar 

Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, Qorbani M, Alavian SM, Daneshi-Maskooni M, Hosseinzadeh-Attar MJ. Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial. Nutr Metab (Lond). 2019;16:8.

Article  PubMed  Google Scholar 

Rahimi HR, Mohammadpour AH, Dastani M, Jaafari MR, Abnous K, Ghayour Mobarhan M, Kazemi Oskuee R. The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial. Avicenna J Phytomed. 2016;6(5):567–77.

CAS  PubMed  PubMed Central  Google Scholar 

Kheiripour N, Khodamoradi Z, Ranjbar A, Borzouei S. The positive effect of short-term nano-curcumin therapy on insulin resistance and serum levels of afamin in patients with metabolic syndrome. Avicenna J Phytomed. 2021;11(2):146–53.

CAS  PubMed  PubMed Central  Google Scholar 

Djalali M, Djalali M, Abdolahi M, Mohammadi H, Heidari H, Hosseini S, Sadeghizadeh M. The Effect of Nano-Curcumin supplementation on Pentraxin 3 Gene expression and serum level in Migraine patients. Rep Biochem Mol Biol. 2020;9(1):1–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hatamipour M, Sahebkar A, Alavizadeh SH, Dorri M, Jaafari MR. Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids. Iran J Basic Med Sci. 2019;22(3):282–9.

PubMed  PubMed Central  Google Scholar 

PATENTSCOPE. WO2019171107 - CURCUMIN NANOMICELLES FOR ORAL ADMINISTRATION: The World Intellectual Property Organization (WIPO). 2019 [ https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019171107&_cid=P22-LHH4DK-84152-1.

Amato MC, Giordano C. Visceral adiposity index: an indicator of adipose tissue dysfunction. Int J Endocrinol. 2014;2014:730827.

Article  PubMed  PubMed Central  Google Scholar 

Liu PJ, Lou HP, Zhu YN. Screening for metabolic syndrome using an Integrated continuous index consisting of Waist circumference and triglyceride: a preliminary cross-sectional study. Diabetes Metab Syndr Obes. 2020;13:2899–907.

Article  PubMed  PubMed Central  Google Scholar 

Taheri-Kharameh Z, Heravi-Karimooi M, Rejeh N, Hajizadeh E, Vaismoradi M, Snelgrove S, Montazeri A. Translation and psychometric testing of the Farsi version of the Seattle angina questionnaire. Health Qual Life Outcomes. 2017;15(1):234.

Article  PubMed  PubMed Central  Google Scholar 

Spertus JA, Winder JA, Dewhurst TA, Deyo RA, Prodzinski J, McDonell M, Fihn SD. Development and evaluation of the Seattle Angina Questionnaire: a new functional status measure for coronary artery disease. J Am Coll Cardiol. 1995;25(2):333–41.

Article  CAS  PubMed 

Comments (0)

No login
gif