Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013;36(Suppl 1):S67–74.

Google Scholar 

Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119.

Article  PubMed  Google Scholar 

Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9(th) edition. Diabetes Res Clin Pract. 2019;157:107843.

Article  PubMed  Google Scholar 

Reddy MA, Zhang E, Natarajan R. Epigenetic mechanisms in diabetic complications and metabolic memory. Diabetologia. 2015;58(3):443–55.

Article  CAS  PubMed  Google Scholar 

Franzon R, Chiarani F, Mendes RH, Belló-Klein A, Wyse AT. Dietary soy prevents brain Na+, K(+)-ATPase reduction in streptozotocin diabetic rats. Diabetes Res Clin Pract. 2005;69(2):107–12.

Article  CAS  PubMed  Google Scholar 

Lester-Coll N, Rivera EJ, Soscia SJ, Doiron K, Wands JR, de la Monte SM. Intracerebral Streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer’s disease. J Alzheimers Dis. 2006;9(1):13–33.

Article  CAS  PubMed  Google Scholar 

Zhang WJ, Tan YF, Yue JT, Vranic M, Wojtowicz JM. Impairment of hippocampal neurogenesis in streptozotocin-treated diabetic rats. Acta Neurol Scand. 2008;117(3):205–10.

Article  PubMed  Google Scholar 

Liu X, Mo Y, Gong J, Li Z, Peng H, Chen J, et al. Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats. Metab Brain Dis. 2016;31(2):417–23.

Article  CAS  PubMed  Google Scholar 

Cooper C, Sommerlad A, Lyketsos CG, Livingston G. Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis. Am J Psychiatry. 2015;172(4):323–34.

Article  PubMed  Google Scholar 

Chowdhary N, Barbui C, Anstey KJ, Kivipelto M, Barbera M, Peters R, et al. Reducing the risk of Cognitive decline and Dementia: WHO recommendations. Front Neurol. 2021;12:765584.

Article  PubMed  Google Scholar 

Gudala K, Bansal D, Schifano F, Bhansali A. Diabetes mellitus and risk of dementia: a meta-analysis of prospective observational studies. J Diabetes Investig. 2013;4(6):640–50.

Article  PubMed  PubMed Central  Google Scholar 

Ninomiya T. Diabetes mellitus and dementia. Curr Diab Rep. 2014;14(5):487.

Article  PubMed  Google Scholar 

Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 2006;5(1):64–74.

Article  PubMed  Google Scholar 

Kloppenborg RP, van den Berg E, Kappelle LJ, Biessels GJ. Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review. Eur J Pharmacol. 2008;585(1):97–108.

Article  CAS  PubMed  Google Scholar 

Zheng B, Su B, Price G, Tzoulaki I, Ahmadi-Abhari S, Middleton L, Glycemic, Control. Diabetic complications, and risk of dementia in patients with diabetes: results from a large U.K. Cohort Study. Diabetes Care. 2021;44(7):1556–63.

Article  CAS  PubMed  Google Scholar 

Lee DY, Kim J, Park S, Park SY, Yu JH, Seo JA, et al. Fasting glucose variability and the risk of Dementia in individuals with diabetes: a Nationwide Cohort Study. Diabetes Metab J. 2022;46(6):923–35.

Article  PubMed  PubMed Central  Google Scholar 

Kuo CL, Lu CL, Chang YH, Li CY. Population-based Cohort Study on Dementia Risk in patients with type 1 diabetes Mellitus. Neuroepidemiology. 2018;50(1–2):57–62.

Article  PubMed  Google Scholar 

Jia Y, Liu R, Tang S, Zhang D, Wang Y, Cong L, et al. Associations of the Glycaemic Control of Diabetes with dementia and physical function in Rural-Dwelling older Chinese adults: a Population-based study. Clin Interv Aging. 2021;16:1503–13.

Article  PubMed  PubMed Central  Google Scholar 

van Gennip ACE, Stehouwer CDA, van Boxtel MPJ, Verhey FRJ, Koster A, Kroon AA, et al. Association of Type 2 diabetes, according to the number of risk factors within target range, with structural brain abnormalities, cognitive performance, and risk of Dementia. Diabetes Care. 2021;44(11):2493–502.

Article  PubMed  PubMed Central  Google Scholar 

Chin SO, Rhee SY, Chon S, Baik SH, Park Y, Nam MS, et al. Hypoglycemia is associated with dementia in elderly patients with type 2 diabetes mellitus: an analysis based on the Korea National Diabetes Program Cohort. Diabetes Res Clin Pract. 2016;122:54–61.

Article  CAS  PubMed  Google Scholar 

Ma F, Wu T, Miao R, Xiao YY, Zhang W, Huang G. Conversion of mild cognitive impairment to dementia among subjects with diabetes: a population-based study of incidence and risk factors with five years of follow-up. J Alzheimers Dis. 2015;43(4):1441–9.

Article  CAS  PubMed  Google Scholar 

Frison E, Dufouil C, Helmer C, Berr C, Auriacombe S, Chêne G. Diabetes-Associated Dementia Risk and competing risk of death in the three-city study. J Alzheimers Dis. 2019;71(4):1339–50.

Article  PubMed  Google Scholar 

Salinas RM, Hiriart M, Acosta I, Sosa AL, Prince MJ. Type 2 diabetes mellitus as a risk factor for dementia in a Mexican population. J Diabetes Complications. 2016;30(7):1234–9.

Article  PubMed  Google Scholar 

Secnik J, Cermakova P, Fereshtehnejad SM, Dannberg P, Johnell K, Fastbom J, et al. Diabetes in a large dementia cohort: clinical characteristics and treatment from the Swedish Dementia Registry. Diabetes Care. 2017;40(9):1159–66.

Article  PubMed  PubMed Central  Google Scholar 

Javanshiri K, Waldö ML, Friberg N, Sjövall F, Wickerström K, Haglund M, et al. Atherosclerosis, hypertension, and diabetes in Alzheimer’s Disease, Vascular Dementia, and mixed dementia: prevalence and presentation. J Alzheimers Dis. 2018;65(4):1247–58.

Article  PubMed  Google Scholar 

Barbiellini Amidei C, Fayosse A, Dumurgier J, Machado-Fragua MD, Tabak AG, van Sloten T, et al. Association between Age at Diabetes Onset and subsequent risk of Dementia. JAMA. 2021;325(16):1640–9.

Article  PubMed  PubMed Central  Google Scholar 

Gong J, Harris K, Hackett M, Peters SAE, Brodaty H, Cooper M, et al. Sex differences in risk factors for cognitive decline and dementia, including death as a competing risk, in individuals with diabetes: results from the ADVANCE trial. Diabetes Obes Metab. 2021;23(8):1775–85.

Article  PubMed  Google Scholar 

Kim WJ, Lee SJ, Lee E, Lee EY, Han K. Risk of Incident Dementia according to Glycemic Status and comorbidities of Hyperglycemia: a Nationwide Population-based Cohort Study. Diabetes Care. 2022;45(1):134–41.

Article  CAS  PubMed  Google Scholar 

Alkabbani W, Maxwell CJ, Marrie RA, Tyas SL, Lega IC, Gamble JM. Hypoglycaemia and the risk of dementia: a population-based cohort study using exposure density sampling. Int J Epidemiol. 2023;52(3):908–20.

Article  PubMed  Google Scholar 

Leibson CL, Rocca WA, Hanson VA, Cha R, Kokmen E, O’Brien PC, et al. Risk of dementia among persons with diabetes mellitus: a population-based cohort study. Am J Epidemiol. 1997;145(4):301–8.

Article  CAS  PubMed  Google Scholar 

Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM. Diabetes mellitus and the risk of dementia: the Rotterdam Study. Neurology. 1999;53(9):1937–42.

Article  CAS  PubMed  Google Scholar 

Yu JT, Xu W, Tan CC, Andrieu S, Suckling J, Evangelou E, et al. Evidence-based prevention of Alzheimer’s disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials. J Neurol Neurosurg Psychiatry. 2020;91(11):1201–9.

Article  PubMed  Google Scholar 

Xue M, Xu W, Ou YN, Cao XP, Tan MS, Tan L, et al. Diabetes mellitus and risks of cognitive impairment and dementia: a systematic review and meta-analysis of 144 prospective studies. Ageing Res Rev. 2019;55:100944.

Article  CAS  PubMed  Google Scholar 

Li ZG, Zhang W, Grunberger G, Sima AA. Hippocampal neuronal apoptosis in type 1 diabetes. Brain Res. 2002;946(2):221–31.

Article  CAS  PubMed  Google Scholar 

Faheem NM, El Askary A. Neuroprotective role of curcumin on the hippocampus against the structural and serological alterations of streptozotocin-induced diabetes in Sprague Dawely rats. Iran J Basic Med Sci. 2017;20(6):690–9.

PubMed  PubMed Central  Google Scholar 

Chen R, Shi J, Yin Q, Li X, Sheng Y, Han J, et al. Morphological and pathological characteristics of Brain in Diabetic Encephalopathy. J Alzheimers Dis. 2018;65(1):15–28.

Article  PubMed  Google Scholar 

Mayeda ER, Whitmer RA, Yaffe K. Diabetes and cognition. Clin Geriatr Med. 2015;31(1):101–15. ix.

Article  PubMed  Google Scholar 

Baglietto-Vargas D, Shi J, Yaeger DM, Ager R, LaFerla FM. Diabetes and Alzheimer’s disease crosstalk. Neurosci Biobehav Rev. 2016;64:272–87.

Article  CAS