Arbyn M, Weiderpass E, Bruni L, de Sanjose S, Saraiya M, Ferlay J, Bray F. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Global Health. 2020;8(2):E191–203.

Article  PubMed  Google Scholar 

Caliceti C, Punzo A, Silla A, Simoni P, Roda G, Hrelia S. New insights into bile acids related signaling pathways in the onset of colorectal cancer. Nutrients. 2022;14(14):2964.

Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66(4):683–91.

Article  PubMed  Google Scholar 

Wang MQ, Li JN, Wang DX, Xin Y, Liu Z. The effects of mesenchymal stem cells on the chemotherapy of colorectal cancer. Biomed Pharmacother. 2023;160:114373.

Ismail NI, Othman I, Abas F, Lajis NH, Naidu R: Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer. Int J Mol Sci. 2019:20(10):2454.

Meisenberg C, Ashour ME, El-Shafie L, Liao CY, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE, El-Khamisy SF. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res. 2017;45(3):1159–76.

PubMed  CAS  Google Scholar 

Yue B, Gao RY, Wang ZT, Dou W. Microbiota-Host-Irinotecan Axis: A New Insight Toward Irinotecan Chemotherapy. Front Cell Infect Microbiol. 2021;11:710945.

Brandi G, Dabard J, Raibaud P, Di Battista M, Bridonneau C, Pisi AM, Labate AMM, Pantaleo MA, De Vivo A, Biasco G. Intestinal microflora and digestive toxicity of irinotecan in mice. Clin Cancer Res. 2006;12(4):1299–307.

Article  PubMed  CAS  Google Scholar 

Kciuk M, Marciniak B, Kontek R. Irinotecan-Still an Important Player in Cancer Chemotherapy: A Comprehensive Overview. Int J Mol Sci. 2020;21(14):4919.

Huang JT, Mao YQ. The impact of the microbiome in cancer: Targeting metabolism of cancer cells and host. Front Oncol 2022;12:1029033.

Claus SP. Inulin prebiotic: is it all about bifidobacteria? Gut. 2017;66(11):1883-+.

Article  PubMed  CAS  Google Scholar 

Bhattacharya S, Moradi D, Bhandari B. Crohn’s Disease Mimicking Perforated Appendicitis. Am J Gastroenterol. 2017;112:S1560–S1560.

Article  Google Scholar 

Li MJ, Ding JH, Stanton C, Ross RP, Zhao JX, Yang B, Chen W. Bifidobacterium longum subsp. infantis FJSYZ1M3 ameliorates DSS-induced colitis by maintaining the intestinal barrier, regulating inflammatory cytokines, and modifying gut microbiota. Food Funct. 2023;14(1):354–68.

Article  PubMed  CAS  Google Scholar 

Quintanilha MF, Miranda VC, Souza RO, Gallotti B, Cruz C, Santos EA, Alvarez-Leite JI, Jesus LCL, Azevedo V, Trindade LM, et al. Bifidobacterium longum subsp. longum 5(1A) attenuates intestinal injury against irinotecan-induced mucositis in mice. Life Sci. 2022;289:120243.

Zhu H, Lu CY, Gao F, Qian ZX, Yin Y, Kan SD, Chen DJ. Selenium-enriched Bifidobacterium longum DD98 attenuates irinotecan-induced intestinal and hepatic toxicity in vitro and in vivo. Biomed Pharmacother. 2021;143:112192.

Ohara T, Suzutani T, Ozkan H. Intake of Bifidobacterium longum and Fructo-oligosaccharides prevents Colorectal Carcinogenesis. Euroasian J Hepato-Gastroenterol. 2018;8(1):11–7.

Article  Google Scholar 

Fang X, Yue M, Wei J, Wang Y, Hong D, Wang B, Zhou X, Chen T. Evaluation of the anti-aging effects of a probiotic combination isolated from centenarians in a SAMP8 mouse model. Front Immunol. 2021;12:792746.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nakajima S. Pica caused by emetic drugs in laboratory rats with kaolin, gypsum, and lime as test substances. Physiol Behav. 2023;261:114076.

Article  PubMed  CAS  Google Scholar 

Yuan CS, Wang CZ, Mehendale SR, Aung HH, Foo A, Israel RJ. Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat model. AIDS Res Ther. 2009;6:19.

Article  PubMed  PubMed Central  Google Scholar 

Qian XX, Cai CW, Li HY, Lai LJ, Song DJ, Qiao YQ, Shen J, Ran ZH. Transcribed ultraconserved region (T-UCR) uc.261 expression is closely correlated with disease activity and intestinal permeability in Crohn’s disease. Ther Adv Gastroenterol. 2019;12:1756284819880733.

Väyrynen JP, Lau MC, Haruki K, Väyrynen SA, Dias Costa A, Borowsky J, Zhao M, Fujiyoshi K, Arima K, Twombly TS, et al. Prognostic significance of immune cell populations identified by machine learning in colorectal cancer using routine hematoxylin and eosin-stained sections. Clin Cancer Res. 2020;26(16):4326–38.

Article  PubMed  PubMed Central  Google Scholar 

Choi YJ, Choi YJ, Kim N, Nam RH, Lee S, Lee HS, Lee HN, Surh YJ, Lee DH. Açaí berries inhibit colon tumorigenesis in Azoxymethane/Dextran sulfate sodium-treated mice. Gut Liver. 2017;11(2):243–52.

Article  PubMed  CAS  Google Scholar 

Guo C, Guo D, Fang L, Sang T, Wu J, Guo C, Wang Y, Wang Y, Chen C, Chen J, et al. Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon. Carbohyd Polym. 2021;267:118231.

Article  CAS  Google Scholar 

Rahman AA, Masango P, Stavely R, Bertrand P, Page A, Nurgali K. Oxaliplatin-Induced Damage to the Gastric Innervation: Role in Nausea and Vomiting. Biomolecules. 2023;13(2):276.

Fidler MM, Bray F, Vaccarella S, Soerjomataram I. Assessing global transitions in human development and colorectal cancer incidence. Int J Cancer. 2017;140(12):2709–15.

Article  PubMed  CAS  Google Scholar 

Riera P, Artigas-Baleri A, Salazar J, Sebio A, Virgili AC, Arranz MJ, Paez D. ABCB1 Genetic Variants as Predictors of Irinotecan-Induced Severe Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients. Front Pharmacol. 2020;11:973.

Kumar S, Sherman MY. Resistance to TOP-1 Inhibitors: Good Old Drugs Still Can Surprise Us. Int J Mol Sci. 2023;24(8):7233.

Ruiz-Losada M, Gonzalez R, Peropadre A, Gil-Galvez A, Tena JJ, Baonza A, Estella C. Coordination between cell proliferation and apoptosis after DNA damage in Drosophila. Cell Death Dif. 2022;29(4):832–45.

Article  CAS  Google Scholar 

Chen J. The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. Cold Spring Harbor Perspect Med. 2016;6(3):a026104.

Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ. 2018;25(1):104–13.

Article  PubMed  CAS  Google Scholar 

Xu X, Iwasa H, Hossain S, Sarkar A, Maruyama J, Arimoto-Matsuzaki K, Hata Y. BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression. Genes Cells. 2017;22(12):993–1003.

Article  PubMed  CAS  Google Scholar 

Ha J-H, Shin J-S, Yoon M-K, Lee M-S, He F, Bae K-H, Yoon HS, Lee C-K, Park SG, Muto Y, et al. Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways. J Biol Chem. 2013;288(10):7387–98.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Park HJ, Kim MJ, Ha E, Chung JH. Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4. Phytomedicine. 2008;15(1–2):147–51.

Article  PubMed  CAS  Google Scholar 

Shirley M. Netupitant/Palonosetron: a review in chemotherapy-induced nausea and vomiting (vol 81, pg 1331, 2021). Drugs. 2021;81(15):1817–1817.

Article  PubMed  PubMed Central  Google Scholar 

Janelsins MC, Tejani MA, Kamen C, Peoples AR, Mustian KM, Morrow GR. Current pharmacotherapy for chemotherapy-induced nausea and vomiting in cancer patients. Expert Opin Pharmacother. 2013;14(6):757–66.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Govindarajan R, Heaton KM, Broadwater R, Zeitlin A, Lang NP, Hauer-Jensen M. Effect of thalidomide on gastrointestinal toxic effects of irinotecan. Lancet. 2000;356(9229):566–7.

Article  PubMed  CAS  Google Scholar 

Hall IC. Context-dependent changes in serotonin in the inferior colliculus. 2010.

Google Scholar 

Matthes S, Bader M. Peripheral serotonin synthesis as a new drug target. Trends Pharmacol Sci. 2018;39(6):560–72.

Article  PubMed  CAS  Google Scholar 

Ma Q, Xing C, Long W, Wang HY, Liu Q, Wang R-F. Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis. J Neuroinflamm. 2019;16:53.

Montagnani M, Bottalico L, Potenza MA, Charitos IA, Topi S, Colella M, Santacroce L. The Crosstalk between Gut Microbiota and Nervous System: A Bidirectional Interaction between Microorganisms and Metabolome. Int J Mol Sci. 2023;24(12):10322.

Di Sabatino A, Santacroce G, Rossi CM, Broglio G, Lenti MV. Role of mucosal immunity and epithelial-vascular barrier in modulating gut homeostasis. Intern Emerg Med. 2023;18(6):1635–46.

Article  PubMed  PubMed Central  Google Scholar 

Maaser C, Langholz E, Gordon H, Burisch J, Ellul P, Ramirez VH, Karakan T, Katsanos KH, Krustins E, Levine A, et al. European Crohn’s and colitis organisation topical review on environmental factors in IBD. J Crohns Colitis. 2017;11(8):905–20.

Brandi G, de Rosa F, Biasco G. Irinotecan toxicity: genes or intestinal microflora? Br J Cancer. 2009;100(6):1017–1017.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ren Z, Chen S, Lv H, Peng L, Yang W, Chen J, Wu Z, Wan C: Effect of Bifidobacterium animalis subsp. lactis SF on enhancing the tumor suppression of irinotecan by regulating the intestinal flora. Pharmacol Res. 2022, 184.

Guo X, Li B, Wen C, Zhang F, Xiang X, Nie L, Chen J, Mao L. TREM2 promotes cholesterol uptake and foam cell formation in atherosclerosis. Cell Mol Life Sci. 2023;80(5):137.

Article  PubMed  CAS  Google Scholar 

Fukui H. Role of Gut Dysbiosis in Liver Diseases: What Have We Learned So Far? Diseases. 2019;7(4):58-Article No.: 58.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Herp S, Brugiroux S, Garzetti D, Ring D, Jochum LM, Beutler M, Eberl C, Hussain S, Walter S, Gerlach RG, et al. Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis. Cell Host Microbe. 2019;25(5):681-+.

Article  PubMed  CAS  Google Scholar 

Fernandes C, Souza Wanderley CW, Souza Silva CM, Muniz HA, Teixeira MA, Pinho Souza NR, Ferreira Candido AG, Falcao RB, Loiola Ponte Souza MH, Carvalho Almeida PR, et al. Role of regulatory T cells in irinotecan-induced intestinal mucositis. Eur J Pharm Sci. 2018;115:158–66.

Article  PubMed  CAS  Google Scholar 

Zhang Y, Ding C, Zhu W, Li X, Chen T, Liu Q, Zhou S, Zhang T-C, Ma W. Chemotherapeutic drugs induce oxidative stress associated with DNA repair and metabolism modulation. Life Sci. 2022;289:120242.

Yan S, Yang B, Zhao J, Zhao J, Stanton C, Ross RP, Zhang H, Chen W. A ropy exopolysaccharide producing strain Bifidobacterium longum subsp. longum YS108R alleviates DSS-induced colitis by maintenance of the mucosal barrier and gut microbiota modulation. Food Funct. 2019;10(3):1595–608.

Article  PubMed  CAS  Google Scholar 

Sharma S, Bhatia R, Devi K, Rawat A, Singh S, Bhadada SK, Bishnoi M, Sharma SS, Kondepudi KK. A synbiotic combination of Bifidobacterium longum Bif10 and Bifidobacterium breve Bif11, isomaltooligosaccharides and finger millet arabinoxylan prevents dextran sodium sulphate induced ulcerative colitis in mice. Int J Biol Macromol. 2023;231:123326.

Shang J, Yang S