Jiang Y, Alam JJ, Gomperts SN, Maruff P, Lemstra AW, Germann UA, et al. Preclinical and randomized clinical evaluation of the p38alpha kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration. Nat Commun. 2022;13(1):5308.
Article CAS PubMed PubMed Central Google Scholar
Alam J, Maruff P, Doctrow SR, Chu H-M, Conway J, Gomperts SN, et al. Association of plasma phosphorylated tau with the response to neflamapimod treatment in patients with dementia with Lewy bodies. Neurology. 2023. https://doi.org/10.1212/WNL.0000000000207755. Published online ahead of print.
Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, et al. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiol Aging. 2016;39:90–8.
Article CAS PubMed Google Scholar
Jarzebowski P, Tang CS, Paulsen O, Hay YA. Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location. Elife. 2021;10.
Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, et al. Reducing endogenous alpha-synuclein mitigates the degeneration of selective neuronal populations in an alzheimer’s disease transgenic mouse model. J Neurosci. 2016;36(30):7971–84.
Article CAS PubMed PubMed Central Google Scholar
Mandler M, Rockenstein E, Overk C, Mante M, Florio J, Adame A, et al. Effects of single and combined immunotherapy approach targeting amyloid beta protein and alpha-synuclein in a dementia with Lewy bodies-like model. Alzheimers Dement. 2019;15(9):1133–48.
Article PubMed PubMed Central Google Scholar
Lin S, Leitao ADG, Fang S, Gu Y, Barber S, Gilliard-Telefoni R, et al. Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy. Neurobiol Dis. 2023;178: 106010.
Article CAS PubMed Google Scholar
Teipel SJ, Fritz HC, Grothe MJ. Alzheimer’s Disease Neuroimaging I. Neuropathologic features associated with basal forebrain atrophy in Alzheimer disease. Neurology. 2020;95(10):e1301–11.
Article CAS PubMed PubMed Central Google Scholar
Fernandez-Cabello S, Kronbichler M, Van Dijk KRA, Goodman JA, Spreng RN, Schmitz TW, et al. Basal forebrain volume reliably predicts the cortical spread of Alzheimer’s degeneration. Brain. 2020;143(3):993–1009.
Article PubMed PubMed Central Google Scholar
Kantarci K, Nedelska Z, Chen Q, Senjem ML, Schwarz CG, Gunter JL, et al. Longitudinal atrophy in prodromal dementia with Lewy bodies points to cholinergic degeneration. Brain Commun. 2022;4(2):fcac013.
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