A Multifaceted Approach to Eye and Head Development: Genetic, Transcriptomic, and Phenotypic Analyses

Morgan, T.H., The origin of five mutations in eye color in Drosophila and their modes of inheritance, Science, 1911, vol. 33, no. 849, pp. 534—537.

Article  CAS  PubMed  Google Scholar 

Kvon, E.Z., Kazmar, T., Stampfel, G., et al., Genome-scale functional characterization of Drosophila developmental enhancers in vivo, Nature, 2014, vol. 512, no. 7512, pp. 91—95. https://doi.org/10.1038/nature13395

Article  CAS  PubMed  Google Scholar 

Ruiz-Losada, M., Blom-Dahl, D., Córdoba, S., et al., Specification and patterning of Drosophila appendages, J. Dev. Biol., 2018, vol. 6, no. 3, p. 17. https://doi.org/10.3390/jdb6030017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Córdoba, S. and Estella, C., Role of notch signaling in leg development in Drosophila melanogaster, in notch signaling in embryology and cancer, Notch Signaling in Embryology, Cham: Springer-Verlag, 2020.

Google Scholar 

Ashburner, M., Hawley R., and Golic, K., Drosophila: A Laboratory Handbook, N.Y.: Cold Spring Harbor Laboratory Press, 2005.

Google Scholar 

Markow, T.A. and O’Grady, P., Drosophila: A Guide to Species Identification and Use, Academic Press, 2005.

Google Scholar 

Love, C.R. and Dauwalder, B., Drosophila as a Model to Study the Blood—Brain Barrier, in Blood—Brain Barrier, New York: Springer-Verlag, 2019.

Google Scholar 

He, B.Z., Ludwig, M.Z., Dickerson, D.A., et al., Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin, Genetics, 2014, vol. 196, no. 2, pp. 557—567. https://doi.org/10.1534/genetics.113.157800

Article  CAS  PubMed  Google Scholar 

Singh, A. and Kango-Singh, M., Molecular Genetics of Axial Patterning, Growth, and Disease in the Drosophila Eye, Cham: Springer-Verlag, 2013.

Book  Google Scholar 

Chow, C.Y., Kelsey, K.J., Wolfner, M.F., et al., Candidate genetic modifiers of retinitis pigmentosa identified by exploiting natural variation in Drosophila, Hum. Mol. Genet., 2016, vol. 25, no. 4, pp. 651—659. https://doi.org/10.1093/hmg/ddv502

Article  CAS  PubMed  Google Scholar 

Anand, D. and Lachke, S.A., Systems biology of lens development: a paradigm for disease gene discovery in the eye, Exp. Eye Res., 2017, vol. 156, pp. 22—33. https://doi.org/10.1016/j.exer.2016.03.010

Article  CAS  PubMed  Google Scholar 

Markitantova, Y. and Simirskii, V., Inherited eye diseases with retinal manifestations through the eyes of homeobox genes, Int. J. Mol. Sci., 2020, vol. 21, no. 5, p. 1602. https://doi.org/10.3390/ijms21051602

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang, M., Zinkgraf, M., Fitzgerald-Cook, C., et al., Using Drosophila to identify naturally occurring genetic modifiers of amyloid beta 42-and tau-induced toxicity, Genes, Genomes, Genetics, 2023, vol. 13, no. 9, p. 132. https://doi.org/10.1093/g3journal/jkad132

Article  CAS  Google Scholar 

Aldrich, J.C., Vanderlinden, L.A., Jacobsen, T.L., et al., Genome-wide association study and transcriptome analysis reveals a complex gene network that regulates opsin gene expression and cell fate determination in Drosophila R7 photoreceptor cells, bioRxiv, 2024, vol. 2024. https://doi.org/10.1101/2024.08.05.606616

Thomas, B.J. and Wassarman, D.A., A fly’s eye view of biology, Trends Genet., 1999, vol. 15, no. 5, pp. 184—190. https://doi.org/10.1016/s0168-9525(99)01720-5

Article  CAS  PubMed  Google Scholar 

Callaerts, P., Clements, J., Francis, C., et al., Pax6 and eye development in Arthropoda, Arthropod Struct. Dev., 2006, vol. 35, no. 4, pp. 379—391. https://doi.org/10.1016/j.asd.2006.09.002

Article  CAS  PubMed  Google Scholar 

Sinn, R. and Wittbrodt, J., An eye on eye development, Mech. Dev., 2013, vol. 130, nos. 6—8, pp. 347—358. https://doi.org/10.1016/j.mod.2013.05.001

Article  CAS  PubMed  Google Scholar 

Baker, N.E., Li, K., Quiquand, M., et al., Eye development, Methods, 2014, vol. 68, no. 1, pp. 252—259. https://doi.org/10.1016/j.ymeth.2014.04.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joly, J.-S., Recher, G., Brombin, A., et al., A conserved developmental mechanism builds complex visual systems in insects and vertebrates, Curr. Biol., 2016, vol. 26, no. 20, pp. R1001—R1009. https://doi.org/10.1016/j.cub.2016.08.017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koenig, K.M., Sun, P., Meyer, E., et al., Eye development and photoreceptor differentiation in the cephalopod Doryteuthis pealeii, Development, 2016, vol. 143, no. 17, pp. 3168—3181. https://doi.org/10.1242/dev.134254

Article  CAS  PubMed  Google Scholar 

Kumar, J.P., The fly eye: through the looking glass, Dev. Dyn., 2018, vol. 247, no. 1, pp. 111—123. https://doi.org/10.1002/dvdy.24585

Article  CAS  PubMed  Google Scholar 

Chen, Y.-C. and Desplan, C., Gene regulatory networks during the development of the Drosophila visual system, Current Topics in Developmental Biology, New York: Elsevier, 2020.

Google Scholar 

Mackay, T.F., Richards, S., Stone, E.A., et al., The Drosophila melanogaster genetic reference panel, Nature, 2012, vol. 482, no. 7384, pp. 173—178. https://doi.org/10.1038/nature10811

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang, W., Massouras, A., Inoue, Y., et al., Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines, Genome Res., 2014, vol. 24, no. 7, pp. 1193—1208. https://doi.org/10.1101/gr.171546.113

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mackay, T.F. and Huang, W.J.W.I.R.D.B., Charting the genotype—phenotype map: lessons from the Drosophila melanogaster Genetic Reference Panel, WIRES Dev. Biol., 2018, vol. 7, no. 1, p. e289. https://doi.org/10.1002/wdev.289

Article  CAS  Google Scholar 

Rueden, C.T., Schindelin, J., Hiner, M.C., et al., ImageJ2: ImageJ for the next generation of scientific image data, BMC Bioinf., 2017, vol. 18, no. 1, p. 529. https://doi.org/10.1186/s12859-017-1934-z

Article  Google Scholar 

Team, R.C., RStudio, Integrated Development Environment for R, Boston, MA: RStudio, 2016.

Hu, Y., Comjean, A., Attrill, H., et al., PANGEA: a new gene set enrichment tool for Drosophila and common research organisms, Nucleic Acids Res., 2023, vol. 51, no. W1, pp. W419—W426. https://doi.org/10.1101/2023.02.20.529262

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yeung, K., Bollepogu Raja, K.K., Shim, Y.-K., et al., Single cell RNA sequencing of the adult Drosophila eye reveals distinct clusters and novel marker genes for all major cell types, Commun. Biol., 2022, vol. 5, no. 1, p. 1370. https://doi.org/10.1038/s42003-022-04337-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bollepogu Raja, K.K., Yeung, K., Shim, Y.-K., et al., A single cell genomics atlas of the Drosophila larval eye reveals distinct photoreceptor developmental timelines, Nat. Commun., 2023, vol. 14, no. 1, p. 7205. https://doi.org/10.1038/s41467-023-43037-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raja, K.K.B., Yeung, K., Li, Y., et al., A single cell RNA sequence atlas of the early Drosophila larval eye, BMC Genomics, 2024, vol. 25, no. 1, p. 616. https://doi.org/10.1186/s12864-024-10423-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Consortium, M., Roy, S., Ernst, J., et al., Identification of functional elements and regulatory circuits by Drosophila modENCODE, Science, 2010, vol. 330, no. 6012, pp. 1787—1797. https://doi.org/10.1126/science.1198374

Article  CAS  Google Scholar 

Larkin, A., Marygold, S.J., Antonazzo, G., et al., FlyBase: updates to the Drosophila melanogaster knowledge base, Nucleic Acids Res, 2021, vol. 49, no. D1, pp. D899—D907. https://doi.org/10.1093/nar/gkaa1026

Article  CAS  PubMed 

Comments (0)

No login
gif