Ahn JH, Cho H, Kim J-H, Kim SH, Ham J-S, Park I, Suh SH, Hong SP, Song J-H, Hong Y-K, Jeong Y, Park S-H, Koh GY (2019) Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid. Nature 572(7767):62–66. https://doi.org/10.1038/s41586-019-1419-5

Article  PubMed  CAS  Google Scholar 

Alemán-Ruiz C, Wang W, Dingledine R, Varvel NH (2023) Pharmacological inhibition of the inflammatory receptor CCR2 relieves the early deleterious consequences of status epilepticus. Sci Rep 13(1):5651. https://doi.org/10.1038/s41598-023-32752-9

Article  PubMed  PubMed Central  CAS  Google Scholar 

Antila S, Karaman S, Nurmi H, Airavaara M, Voutilainen MH, Mathivet T, Chilov D, Li Z, Koppinen T, Park J-H, Fang S, Aspelund A, Saarma M, Eichmann A, Thomas J-L, Alitalo K (2017) Development and plasticity of meningeal lymphatic vessels. J Exp Med 214(12):3645–3667. https://doi.org/10.1084/jem.20170391

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bateman GA, Bateman AR (2024) The dilated veins surrounding the cord in multiple sclerosis suggest elevated pressure and obstruction of the glymphatic system. Neuroimage 286:120517. https://doi.org/10.1016/j.neuroimage.2024.120517

Article  PubMed  Google Scholar 

Bearoff F, Dhavale D, Kotzbauer P, Kortagere S (2023) Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells. Mol Immunol 154:1–10. https://doi.org/10.1016/j.molimm.2022.12.006

Article  PubMed  CAS  Google Scholar 

Bennett HC, Zhang Q, Wu Y, Manjila SB, Chon U, Shin D, Vanselow DJ, Pi H-J, Drew PJ, Kim Y (2024) Aging drives cerebrovascular network remodeling and functional changes in the mouse brain. Nat Commun 15(1):6398. https://doi.org/10.1038/s41467-024-50559-8

Article  PubMed  PubMed Central  CAS  Google Scholar 

Berer K, Gerdes LA, Cekanaviciute E, Jia X, Xiao L, Xia Z, Liu C, Klotz L, Stauffer U, Baranzini SE, Kümpfel T, Hohlfeld R, Krishnamoorthy G, Wekerle H (2017) Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A 114(40):10719–10724. https://doi.org/10.1073/pnas.1711233114

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bhatt S, Nagappa AN, Patil CR (2020) Role of oxidative stress in depression. Drug Discov Today 25(7):1270–1276. https://doi.org/10.1016/j.drudis.2020.05.001

Article  PubMed  CAS  Google Scholar 

Boisserand LSB, Geraldo LH, Bouchart J, El Kamouh M-R, Lee S, Sanganahalli BG, Spajer M, Zhang S, Lee S, Parent M, Xue Y, Skarica M, Yin X, Guegan J, Boyé K, Saceanu Leser F, Jacob L, Poulet M, Li M et al (2024) VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model. J Exp Med 221(4):e20221983. https://doi.org/10.1084/jem.20221983

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bolte AC, Dutta AB, Hurt ME, Smirnov I, Kovacs MA, McKee CA, Ennerfelt HE, Shapiro D, Nguyen BH, Frost EL, Lammert CR, Kipnis J, Lukens JR (2020) Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis. Nat Commun 11(1):4524. https://doi.org/10.1038/s41467-020-18113-4

Article  PubMed  PubMed Central  CAS  Google Scholar 

Boxerman JL, Hawash K, Bali B, Clarke T, Rogg J, Pal DK (2007) Is rolandic epilepsy associated with abnormal findings on cranial MRI? Epilepsy Res 75(2–3):180–185. https://doi.org/10.1016/j.eplepsyres.2007.06.001

Article  PubMed  PubMed Central  Google Scholar 

Braun M, Sevao M, Keil SA, Gino E, Wang MX, Lee J, Haveliwala MA, Klein E, Agarwal S, Pedersen T, Rhodes CH, Jansson D, Cook D, Peskind E, Perl DP, Piantino J, Schindler AG, Iliff JJ (2024) Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function. Brain 147(6):2214–2229. https://doi.org/10.1093/brain/awae065

Article  PubMed  PubMed Central  Google Scholar 

Brosnan CF, Raine CS (2013) The astrocyte in multiple sclerosis revisited. Glia 61(4):453–465. https://doi.org/10.1002/glia.22443

Article  PubMed  Google Scholar 

Carotenuto A, Cacciaguerra L, Pagani E, Preziosa P, Filippi M, Rocca MA (2022) Glymphatic system impairment in multiple sclerosis: relation with brain damage and disability. Brain 145(8):2785–2795. https://doi.org/10.1093/brain/awab454

Article  PubMed  Google Scholar 

Cekanaviciute E, Pröbstel AK, Thomann A, Runia TF, Casaccia P, Katz Sand I, Crabtree E, Singh S, Morrissey J, Barba P, Gomez R, Knight R, Mazmanian S, Graves J, Cree BAC, Zamvil SS, Baranzini SE (2018) Multiple sclerosis-associated changes in the composition and immune functions of spore-forming bacteria. mSystems 3(6):e00083-18. https://doi.org/10.1128/mSystems.00083-18

Article  PubMed  PubMed Central  Google Scholar 

Cervellati C, Trentini A, Pecorelli A, Valacchi G (2020) Inflammation in neurological disorders: the thin boundary between brain and periphery. Antioxid Redox Signal 33(3):191–210. https://doi.org/10.1089/ars.2020.8076

Article  PubMed  CAS  Google Scholar 

Chen J-H, Yang L-K, Chen L, Wang Y-H, Wu Y, Jiang B-J, Zhu J, Li P-P (2016) Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of AQP4 expression in rabbits. Int J Mol Med 37(4):1059–1066. https://doi.org/10.3892/ijmm.2016.2506

Article  PubMed  CAS  Google Scholar 

Chi Y, Fan Y, He L, Liu W, Wen X, Zhou S, Wang X, Zhang C, Kong H, Sonoda L, Tripathi P, Li CJ, Yu MS, Su C, Hu G (2011) Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson’s disease: AQP4 in Treg cell development and severity of PD. Aging Cell 10(3):368–382. https://doi.org/10.1111/j.1474-9726.2011.00677.x

Article  PubMed  CAS  Google Scholar 

Chong PLH, Garic D, Shen MD, Lundgaard I, Schwichtenberg AJ (2022) Sleep, cerebrospinal fluid, and the glymphatic system: a systematic review. Sleep Med Rev 61:101572. https://doi.org/10.1016/j.smrv.2021.101572

Article  PubMed  CAS  Google Scholar 

Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, Dubin AE, Patapoutian A (2010) Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science (New York NY) 330(6000):55–60. https://doi.org/10.1126/science.1193270

Article  CAS  Google Scholar 

Cruz-Sanabria F, Carmassi C, Bruno S, Bazzani A, Carli M, Scarselli M, Faraguna U (2023) Melatonin as a chronobiotic with sleep-promoting properties. Curr Neuropharmacol 21(4):951–987. https://doi.org/10.2174/1570159X20666220217152617

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cserr HF, Cooper DN, Suri PK, Patlak CS (1981) Efflux of radiolabeled polyethylene glycols and albumin from rat brain. Am J Physiol-Renal Physiol 240(4):F319–F328. https://doi.org/10.1152/ajprenal.1981.240.4.F319

Article  CAS  Google Scholar 

Dai W, Yang M, Xia P, Xiao C, Huang S, Zhang Z, Cheng X, Li W, Jin J, Zhang J, Wu B, Zhang Y, Wu P, Lin Y, Wu W, Zhao H, Zhang Y, Lin W-J, Ye X (2022) A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice. Nat Commun 13(1):4825. https://doi.org/10.1038/s41467-022-32556-x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Daini E, Secco V, Liao W, Zoli M, Vilella A (2021) A regional and cellular analysis of the early intracellular and extracellular accumulation of Aβ in the brain of 5XFAD mice. Neurosci Lett 754:135869. https://doi.org/10.1016/j.neulet.2021.135869

Article  PubMed  CAS  Google Scholar 

Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich SS, Munson JM et al (2018) Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease. Nature 560(7717):185–191. https://doi.org/10.1038/s41586-018-0368-8

Article  PubMed  PubMed Central  CAS  Google Scholar 

Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, Dabhi N, Kennedy T, Milam MG, Baker W et al (2021) Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. Nature 593(7858):255–260. https://doi.org/10.1038/s41586-021-03489-0