The transcriptional regulation of NUPR1 expression by MYC is implicated in the regulation of ferroptosis in human spermatogonial stem cells

Fakhro KA, Elbardisi H, Arafa M, Robay A, Rodriguez-Flores JL, Al-Shakaki A, Syed N, Mezey JG, Abi Khalil C, Malek JA, Al-Ansari A, Al Said S, Crystal RG (2018) Point-of-care whole-exome sequencing of idiopathic male infertility. Genet Med 20(11):1365–1373. https://doi.org/10.1038/gim.2018.10

Article  PubMed  CAS  Google Scholar 

Zhao L, Yao C, Xing X, Jing T, Li P, Zhu Z, Yang C, Zhai J, Tian R, Chen H, Luo J, Liu N, Deng Z, Lin X, Li N, Fang J, Sun J, Wang C, Zhou Z, Li Z (2020) Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells. Nat Commun 11(1):5683. https://doi.org/10.1038/s41467-020-19414-4

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hamada AJ, Esteves SC, Agarwal A (2013) A comprehensive review of genetics and genetic testing in azoospermia. Clinics 68 suppl 1. Suppl 139–60. https://doi.org/10.6061/clinics/2013(sup01)06

Svingen T, Koopman P (2013) Building the mammalian testis: origins, differentiation, and assembly of the component cell populations. Genes Dev 27(22):2409–2426. https://doi.org/10.1101/gad.228080.113

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nishimura H, L’Hernault SW (2017) Spermatogenesis. Current biology: CB 27(18):R988–R994. https://doi.org/10.1016/j.cub.2017.07.067

Article  PubMed  CAS  Google Scholar 

O’Donnell L, Smith LB, Rebourcet D (2022) Sertoli cells as key drivers of testis function. Semin Cell Dev Biol 121:2–9. https://doi.org/10.1016/j.semcdb.2021.06.016

Article  PubMed  CAS  Google Scholar 

Zhou R, Wu J, Liu B, Jiang Y, Chen W, Li J, He Q, He Z (2019) The roles and mechanisms of Leydig cells and myoid cells in regulating spermatogenesis. Cell Mol Life Sci 76(14):2681–2695. https://doi.org/10.1007/s00018-019-03101-9

Article  PubMed  PubMed Central  CAS  Google Scholar 

Piechka A, Sparanese S, Witherspoon L, Hach F, Flannigan R (2024) Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia. Nat Rev Urol 21(2):67–90. https://doi.org/10.1038/s41585-023-00837-9

Article  PubMed  CAS  Google Scholar 

Liu W, Du L, Li J, He Y, Tang M (2024) Microenvironment of spermatogonial stem cells: a key factor in the regulation of spermatogenesis. Stem Cell Res Ther 15(1):294. https://doi.org/10.1186/s13287-024-03893-z

Article  PubMed  PubMed Central  Google Scholar 

Hou J, Niu M, Liu L, Zhu Z, Wang X, Sun M, Yuan Q, Yang S, Zeng W, Liu Y (2015) Establishment and characterization of human germline stem cell line with unlimited proliferation potentials and no tumor formation. Sci Rep 5(1):16922

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cui Y, Chen W, Du L, He Z (2023) OIP5 interacts with NCK2 to mediate human spermatogonial stem cell self-renewal and apoptosis through cell cyclins and cycle progression and its abnormality is correlated with male infertility. Research 6:0162. https://doi.org/10.34133/research.0162

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22(4):266–282. https://doi.org/10.1038/s41580-020-00324-8

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ren JX, Sun X, Yan XL, Guo ZN, Yang Y (2020) Ferroptosis in neurological diseases. Front Cell Neurosci 14:218. https://doi.org/10.3389/fncel.2020.00218

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lei G, Zhuang L, Gan B (2022) Targeting ferroptosis as a vulnerability in cancer. Nat Rev Cancer 22(7):381–396. https://doi.org/10.1038/s41568-022-00459-0

Article  PubMed  PubMed Central  CAS  Google Scholar 

Davidson AJ, Heron R, Das J, Overholtzer M, Wood W (2024) Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila. Nat Cell Biol 26(9):1535–1544. https://doi.org/10.1038/s41556-024-01450-7

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mou Y, Wang J, Wu J, He D, Zhang C, Duan C, Li B (2019) Ferroptosis, a new form of cell death: opportunities and challenges in cancer. J Hematol Oncol 12(1):34. https://doi.org/10.1186/s13045-019-0720-y

Article  PubMed  PubMed Central  Google Scholar 

Turner TT, Lysiak JJ (2008) Oxidative stress: a common factor in testicular dysfunction. J Androl 29(5):488–498. https://doi.org/10.2164/jandrol.108.005132

Article  PubMed  CAS  Google Scholar 

Tang D, Chen X, Kang R, Kroemer G (2021) Ferroptosis: molecular mechanisms and health implications. Cell Res 31(2):107–125. https://doi.org/10.1038/s41422-020-00441-1

Article  PubMed  CAS  Google Scholar 

Wang M, Wang XF, Li YM, Chen N, Fan Y, Huang WK, Hu SF, Rao M, Zhang YZ, Su P (2020) Cross-talk between autophagy and apoptosis regulates testicular injury/recovery induced by cadmium via PI3K with mTOR-independent pathway. Cell Death Dis 11(1):46. https://doi.org/10.1038/s41419-020-2246-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

McClusky LM (2022) Several routes of cell death to secondary necrosis in the elasmobranch testis. Apoptosis: Int J Program Cell Death 27(7–8):454–464. https://doi.org/10.1007/s10495-022-01733-0

Article  Google Scholar 

Higuchi M, Celino FT, Shimizu-Yamaguchi S, Miura C, Miura T (2012) Taurine plays an important role in the protection of spermatogonia from oxidative stress. Amino Acids 43(6):2359–2369. https://doi.org/10.1007/s00726-012-1316-9

Article  PubMed  CAS  Google Scholar 

Radaelli E, Assenmacher CA, Verrelle J, Banerjee E, Manero F, Khiati S, Girona A, Lopez-Lluch G, Navas P, Spinazzi M (2023) Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis. eLife 12:e84710. https://doi.org/10.7554/eLife.84710

Article  PubMed  PubMed Central  Google Scholar 

Hao X, Wang H, Cui F, Yang Z, Ye L, Huang R, Meng J (2023) Reduction of SLC7A11 and GPX4 contributing to ferroptosis in sperm from asthenozoospermia individuals. Reprod Sci 30(1):247–257. https://doi.org/10.1007/s43032-022-01004-y

Article  PubMed  CAS  Google Scholar 

Li C, Chen W, Cui Y, Zhang D, Yuan Q, Yu X, He Z (2024) Essential regulation of YAP1 in fate determinations of spermatogonial stem cells and male fertility by interacting with RAD21 and targeting NEDD4 in humans and mice. Research 7:0544. https://doi.org/10.34133/research.0544

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wan C, Chen W, Cui Y, He Z (2022) MAP4K4/JNK signaling pathway stimulates proliferation and suppresses apoptosis of human spermatogonial stem cells and lower level of MAP4K4 is associated with male infertility. Cells 11(23):3807. https://doi.org/10.3390/cells11233807

Article  PubMed  PubMed Central  Google Scholar 

Zhou D, Zhu F, Huang ZH, Zhang H, Fan LQ, Fan JY (2022) SPOC domain-containing protein 1 regulates the proliferation and apoptosis of human spermatogonial stem cells through adenylate kinase 4. World J Stem Cells 14(12):822–838. https://doi.org/10.4252/wjsc.v14.i12.822

Article  PubMed  PubMed Central  Google Scholar 

Zhou D, Fan J, Liu Z, Tang R, Wang X, Bo H, Zhu F, Zhao X, Huang Z, Xing L, Tao K, Zhang H, Nie H, Zhang H, Zhu W, He Z, Fan L (2021) TCF3 regulates the proliferation and apoptosis of human spermatogonial stem cells by targeting PODXL. Front Cell Dev Biology 9:695545. https://doi.org/10.3389/fcell.2021.695545

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