Abdel-Rahman RF, Alqasoumi SI, Ogaly HÁ, Abd-Elsalam RM, El-Banna HÁ, Soliman GA (2020) Propolis ameliorates cerebral injury in focal cerebral ischemia/reperfusion (I/R) rat model via upregulation of TGF-β1. Saudi Pharm J 28:116–126. https://doi.org/10.1016/j.jsps.2019.11.013

Article  PubMed  CAS  Google Scholar 

Aguiar RP, Soares LM, Meyer E, Silveira FC, Milani H, Newman-Tancredi A, Varney M, Prickaerts J, Oliveira RMW (2020) Activation of 5-HT1A postsynaptic receptors by NLX-101 results in functional recovery and an increase in neuroplasticity in mice with brain ischemia. Prog Neuro-Psychopharmacol Biol Psychiatry 99:109832. https://doi.org/10.1016/j.pnpbp.2019.109832

Article  CAS  Google Scholar 

Alexandridis P, Hatton TA (1995) Poly(ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling. Colloids Surf A Physicochem Eng Asp 96:1–46. https://doi.org/10.1016/0927-7757(94)03028-X

Article  CAS  Google Scholar 

Anderson CA, Arciniegas DB (2010) Cognitive sequelae of hypoxic-ischemic brain injury: a review. NeuroRehabilitation 26:47–63. https://doi.org/10.3233/NRE-2010-0535

Article  PubMed  Google Scholar 

Bacarin CC, Godinho J, Oliveira RMW, Matsushita M, Gohara AK, Cardozo-Filho L, Lima JC, Previdelli IS, Ribeiro Melo SR., MRDM, Milani M, (2016) Postischemic fish oil treatment restores long-term retrograde memory and dendritic density: an analysis of the time window of efficacy. Behav Brain Res 311:425–439. https://doi.org/10.1016/j.bbr.2016.05.047

Article  PubMed  CAS  Google Scholar 

Bonato JM, Meyer EM, Mendonça PSB, Milani H, Prickaerts J, Oliveira RMW (2021) Roflumilast protects against spatial memory impairments and exerts anti-inflammatory effects after transient global cerebral ischemia. Eur J Neurosci 53:1171–1188. https://doi.org/10.1111/ejn.15089

Article  PubMed  CAS  Google Scholar 

Bruschi ML, Cardoso ML, Lucchesi MB, Gremião MP (2003) Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization. Int J Pharm 264:45–55. https://doi.org/10.1016/s0378-5173(03)00386-7

Article  PubMed  CAS  Google Scholar 

Bruschi ML, Jones DS, Panzeri H, Gremião MP, de Freitas O, Lara EH (2007) Semisolid systems containing propolis for the treatment of periodontal disease: in vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties. J Pharm Sci 96:2074–2089. https://doi.org/10.1002/jps.20843

Article  PubMed  CAS  Google Scholar 

Burdock GA (1998) Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol 36:347–363. https://doi.org/10.1016/s0278-6915(97)00145-2

Article  PubMed  CAS  Google Scholar 

Carola V, D’Olimpio F, Brunamonti E, Mangia F, Renzi P (2002) Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice. Behav Brain Res 134:49–57. https://doi.org/10.1016/s0166-4328(01)00452-1

Article  PubMed  Google Scholar 

Celebi G, Gocmez SS, Ozer C, Duruksu G, Yazır Y, Utkan T (2023) Propolis prevents vascular endothelial dysfunction by attenuating inflammation and oxidative damage in the chronic unpredictable stress model of depression in rats. J Pharm Pharmacol 75:1418–1429. https://doi.org/10.1093/jpp/rgad071

Article  PubMed  CAS  Google Scholar 

Chen WN, Shaikh MF, Bhuvanendran S, Date A, Ansari MT, Radhakrishnan AK, Othman I (2022) Poloxamer 188 (P188), a potential polymeric protective agent for central nervous system disorders: a systematic review. Curr Neuropharmacol 20:799–808. https://doi.org/10.2174/1570159X19666210528155801

Article  PubMed  PubMed Central  Google Scholar 

Costa P, Somensi LB, da Silva RCMVAF, Mariano LNB, Boeing T, Longo B, Perfoll E, de Souza P, Gushiken LFS, Pellizzon CH, Rodrigues DM, Bastos JK, de Andrade SF, da Silva LM (2020) Role of the antioxidant properties in the gastroprotective and gastric healing activity promoted by Brazilian green propolis and the healing efficacy of artepillin C. Inflammopharmacology 28:1009–1025. https://doi.org/10.1007/s10787-019-00649-7

Article  PubMed  CAS  Google Scholar 

Feigin VL, Brainin M, Norrving B, Martins S, Sacco RL, Hacke W, Fisher M, Pandian J, Lindsay P (2022) World stroke organization (WSO): global stroke fact sheet 2022. Int Journal Stroke 17:18–29. https://doi.org/10.1177/17474930211065917

Article  Google Scholar 

Fiorini AC, Scorza CA, de Almeida AG, Fonseca MCM, Finsterer J, Fonseca FLA, Scorza FA (2021) Antiviral activity of Brazilian green propolis extract against SARS-CoV-2 (Severe Acute Respiratory Syndrome - Coronavirus 2) infection: case report and review. Clinics 76:e2357. https://doi.org/10.6061/clinics/2021/e2357

Article  PubMed  PubMed Central  Google Scholar 

García-Chávez D, González-Burgos I, Letechipía-Vallejo L-L, Moralí G, Cervantes M (2008) Long-term evaluation of cytoarchitectonic characteristics of prefrontal cortex pyramidal neurons, following global cerebral ischemia and neuroprotective melatonin treatment, in rats. Neurosci Lett 448:148–152. https://doi.org/10.1016/j.neulet.2008.10.043

Article  PubMed  CAS  Google Scholar 

Gao W, Wu J, Wei J, Pu L, Guo C, Yang J, Yang M, Luo H (2014) Brazilian green propolis improves immune function in aged mice. J Clin Biochem Nutr 55:7–10. https://doi.org/10.3164/jcbn.13-70

Article  PubMed  PubMed Central  CAS  Google Scholar 

Godinho J, de Oliveira RMW, de Sa-Nakanishi AB, Bacarin CC, Huzita CH, Longhini R, Mello JCP, Nakamura CV, Previdelli IS, Dal Molin Ribeiro MH, Milani H (2018) Ethyl-acetate fraction of Trichilia catigua restores long-term retrograde memory and reduces oxidative stress and inflammation after global cerebral ischemia in rats. Behav Brain Res 337:173–182. https://doi.org/10.1016/j.bbr.2017.08.050

Article  PubMed  CAS  Google Scholar 

Horstmann A, Frisch S, Jentzsc RT, Müller K, Villringer A, Schroeter ML (2010) Resuscitating the heart but losing the brain: brain atrophy in the aftermath of cardiac arrest. Neurology 74:306–312. https://doi.org/10.1212/WNL.0b013e3181cbcd6f

Article  PubMed  CAS  Google Scholar 

Inagaki R, Yamakuni T, Saito T, Saido TC, Moriguchi S (2024) Preventive effect of propolis on cognitive decline in Alzheimer’s disease model mice. Neurobiol Aging 139:20–29. https://doi.org/10.1016/j.neurobiolaging.2024.03.002

Article  PubMed  CAS  Google Scholar 

Ito T, Degawa T, Okumura N (2023) Brazilian green propolis prevent Alzheimer’s disease-like cognitive impairment induced by amyloid beta in mice. BMC Complement Med Ther 23:416. https://doi.org/10.1186/s12906-023-04247-7

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kischkel B, Castilho PF, de Oliveira KM, Rezende PS, Bruschi ML, Svidzinski TI, Negri M (2020) Silver nanoparticles stabilized with propolis show reduced toxicity and potential activity against fungal infections. Fut Microbiol 15:521–539. https://doi.org/10.2217/fmb-2019-0173

Article  CAS  Google Scholar 

Kumazawa S, Hamasaka T, Nakayama T (2004) Antioxidant activity of propolis of various geographic origins. Food Chem 84:329–339. https://doi.org/10.1016/S0308-8146(03)00216-4

Article  CAS  Google Scholar 

Li YJ, Xuan HZ, Shou QY, Zhan ZG, Lu X, Hu FL (2012) Therapeutic effects of propolis essential oil on anxiety of restraint-stressed mice. Hum Exp Toxicol 31:157–165. https://doi.org/10.1177/0960327111412805

Article  PubMed  CAS  Google Scholar 

Marcucci MC (1996) Biological and therapeutic properties of chemical propolis constituents. Quim Nova 19:529–536. https://doi.org/10.20396/chemkeys.v0i10.9640

Article  CAS  Google Scholar 

Meccatti VM, Martins KMC, Ramos LP, Pereira TC, de Menezes RT, Marcucci MC, Abu Hasna A, de Oliveira LD (2023) Synergistic antibiofilm action of Cinnamomum verum and Brazilian green propolis hydroethanolic extracts against multidrug-resistant strains of Acinetobacter baumannii and Pseudomonas aeruginosa and their biocompatibility on human keratinocytes. Molecules 28:6904. https://doi.org/10.3390/molecules28196904

Article  PubMed  CAS  Google Scholar 

Mori MA, Meyer E, Soares LM, Milani H, Guimarães FS, de Oliveira RMW (2017) Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia. Prog Neuro-Psychopharmacol Biol Psychiatry 75:94–105. https://doi.org/10.1016/j.pnpbp.2016.11.005

Article  CAS  Google Scholar 

Mori MA, Meyer E, da Silva FF, Milani H, Guimarães FS, Oliveira RMW (2021) Differential contribution of CB1, CB2, 5-HT1A, and PPAR-γ receptors to c