Clinical applications of circulating tumor cells in metastasis and therapy

Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell. 2011;147:275–92. https://doi.org/10.1016/j.cell.2011.09.024.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin D, et al. Circulating tumor cells: biology and clinical significance. Signal Transduct Target Ther. 2021;6:404. https://doi.org/10.1038/s41392-021-00817-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ring A, Nguyen-Sträuli BD, Wicki A, Aceto N. Biology, vulnerabilities and clinical applications of Circulating tumour cells. Nat Rev Cancer. 2023;23:95–111. https://doi.org/10.1038/s41568-022-00536-4.

Article  CAS  PubMed  Google Scholar 

Gerstberger S, Jiang Q, Ganesh K. Metastasis Cell. 2023;186:1564–79. https://doi.org/10.1016/j.cell.2023.03.003.

Article  CAS  PubMed  Google Scholar 

Driemel C, et al. Context-dependent adaption of EpCAM expression in early systemic esophageal cancer. Oncogene. 2014;33:4904–15. https://doi.org/10.1038/onc.2013.441.

Article  CAS  PubMed  Google Scholar 

Zhang L, et al. The identification and characterization of breast cancer CTCs competent for brain metastasis. Sci Transl Med. 2013;5:180ra148. https://doi.org/10.1126/scitranslmed.3005109.

Article  CAS  Google Scholar 

Rao CG, et al. Expression of epithelial cell adhesion molecule in carcinoma cells present in blood and primary and metastatic tumors. Int J Oncol. 2005;27:49–57.

CAS  PubMed  Google Scholar 

Gorges TM, et al. Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition. BMC Cancer. 2012;12:178. https://doi.org/10.1186/1471-2407-12-178.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kallergi G, et al. Epithelial to mesenchymal transition markers expressed in Circulating tumour cells of early and metastatic breast cancer patients. Breast Cancer Res. 2011;13:R59. https://doi.org/10.1186/bcr2896.

Article  PubMed  PubMed Central  Google Scholar 

Huaman J, Naidoo M, Zang X, Ogunwobi OO. Fibronectin regulation of integrin B1 and SLUG in Circulating tumor cells. Cells. 2019;8. https://doi.org/10.3390/cells8060618.

Zhang Z, et al. Dynamic monitoring of EMT in CTCs as an indicator of cancer metastasis. Anal Chem. 2021;93:16787–95. https://doi.org/10.1021/acs.analchem.1c03167.

Article  CAS  PubMed  Google Scholar 

Cierna Z, et al. Matrix metalloproteinase 1 and Circulating tumor cells in early breast cancer. BMC Cancer. 2014;14:472. https://doi.org/10.1186/1471-2407-14-472.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mego M, et al. Circulating tumor cells with Epithelial-to-mesenchymal transition phenotypes associated with inferior outcomes in primary breast cancer. Anticancer Res. 2019;39:1829–37. https://doi.org/10.21873/anticanres.13290.

Article  CAS  PubMed  Google Scholar 

Yu M, et al. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science. 2013;339:580–4. https://doi.org/10.1126/science.1228522.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang J, et al. Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2020;21:341–52. https://doi.org/10.1038/s41580-020-0237-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Padmanaban V, et al. E-cadherin is required for metastasis in multiple models of breast cancer. Nature. 2019;573:439–44. https://doi.org/10.1038/s41586-019-1526-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fischer KR, et al. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature. 2015;527:472–6. https://doi.org/10.1038/nature15748.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, et al. Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis. Sci Adv. 2019;5:eaav4275. https://doi.org/10.1126/sciadv.aav4275.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell. 2011;20:576–90. https://doi.org/10.1016/j.ccr.2011.09.009.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sprouse ML, et al. PMN-MDSCs enhance CTC metastatic properties through reciprocal interactions via ros/notch/nodal signaling. Int J Mol Sci. 2019;20. https://doi.org/10.3390/ijms20081916.

Sun YF, et al. Circulating tumor cells from different vascular sites exhibit Spatial heterogeneity in epithelial and mesenchymal composition and distinct clinical significance in hepatocellular carcinoma. Clin Cancer Res. 2018;24:547–59. https://doi.org/10.1158/1078-0432.Ccr-17-1063.

Article  CAS  PubMed  Google Scholar 

Wang SH, Lin SY. Tumor dormancy: potential therapeutic target in tumor recurrence and metastasis prevention. Exp Hematol Oncol. 2013;2:29. https://doi.org/10.1186/2162-3619-2-29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giancotti FG. Mechanisms governing metastatic dormancy and reactivation. Cell. 2013;155:750–64. https://doi.org/10.1016/j.cell.2013.10.029.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Solomayer EF, et al. Influence of Zoledronic acid on disseminated tumor cells in primary breast cancer patients. Ann Oncol. 2012;23:2271–7. https://doi.org/10.1093/annonc/mdr612.

Article  PubMed  Google Scholar 

Braun S, et al. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med. 2000;342:525–33. https://doi.org/10.1056/nejm200002243420801.

Article  CAS  PubMed  Google Scholar 

Janni W, et al. Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse–a European pooled analysis. Clin Cancer Res. 2011;17:2967–76. https://doi.org/10.1158/1078-0432.Ccr-10-2515.

Article  PubMed  Google Scholar 

Wiedswang G, et al. Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer. J Clin Oncol. 2003;21:3469–78. https://doi.org/10.1200/jco.2003.02.009.

Article  CAS  PubMed  Google Scholar 

Hüsemann Y, et al. Systemic spread is an early step in breast cancer. Cancer Cell. 2008;13:58–68. https://doi.org/10.1016/j.ccr.2007.12.003.

Article  CAS  PubMed  Google Scholar 

Demeulemeester J, et al. Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing. Genome Biol. 2016;17:250. https://doi.org/10.1186/s13059-016-1109-7.

Article  PubMed  PubMed Central  Google Scholar 

Merugu S, et al. Detection of Circulating and disseminated neuroblastoma cells using the imagestream flow cytometer for use as predictive and pharmacodynamic biomarkers. Clin Cancer Res. 2020;26:122–34. https://doi.org/10.1158/

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