Koufman JA, Aviv JE, Casiano RR, Shaw GY. Laryngopharyngeal reflux: position statement of the committee on speech, voice, and swallowing disorders of the American academy of Otolaryngology-Head and neck surgery. Otolaryngol Head Neck Surg. 2002;127(1):32–5.

Article  PubMed  Google Scholar 

Copper MP, Smit CF, Stanojcic LD, Devriese PP, Schouwenburg PF, Mathus-Vliegen LM. High incidence of laryngopharyngeal reflux in patients with head and neck cancer. Laryngoscope. 2000;110(6):1007–11.

Article  CAS  PubMed  Google Scholar 

Barrett CM, Patel D, Vaezi MF. Laryngopharyngeal reflux and atypical gastroesophageal reflux disease. Gastrointest Endosc Clin N Am. 2020;30(2):361–76.

Article  PubMed  Google Scholar 

Kamani T, Penney S, Mitra I, Pothula V. The prevalence of laryngopharyngeal reflux in the english population. Eur Arch Otorhinolaryngol. 2012;269(10):2219–25.

Article  PubMed  Google Scholar 

Lechien JR, Dapri G, Dequanter D, Rodriguez Ruiz A, Marechal MT, De Marrez LG, et al. Surgical treatment for laryngopharyngeal reflux disease: A systematic review. JAMA Otolaryngol - Head Neck Surg. 2019;145(7):655–66.

Article  PubMed  Google Scholar 

Koufman JA, Amin MR, Panetti M. Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngol Head Neck Surg. 2000;123(4):385–8.

Article  CAS  PubMed  Google Scholar 

Li Y, Xu G, Zhou B, Tang Y, Liu X, Wu Y, et al. Effects of acids, pepsin, bile acids, and trypsin on laryngopharyngeal reflux diseases: physiopathology and therapeutic targets. Eur Arch Otorhinolaryngol. 2022;279(6):2743–52.

Article  PubMed  Google Scholar 

Lien HC, Wang CC, Kao JY, Yeh HZ, Hsu JY, Lee SW, et al. Distinct physiological characteristics of isolated laryngopharyngeal reflux symptoms. Clin Gastroenterol Hepatol. 2020;18(7):1466–e744.

Article  CAS  PubMed  Google Scholar 

Vaezi MF, Hicks DM, Abelson TI, Richter JE. Laryngeal signs and symptoms and gastroesophageal reflux disease (GERD): a critical assessment of cause and effect association. Clin Gastroenterol Hepatol. 2003;1(5):333–44.

Article  PubMed  Google Scholar 

Johnston N, Knight J, Dettmar PW, Lively MO, Koufman J. Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope. 2004;114(12):2129–34.

Article  CAS  PubMed  Google Scholar 

De Corso E, Baroni S, Salonna G, Marchese M, Graziadio M, Di Cintio G, et al. Impact of bile acids on the severity of laryngo-pharyngeal reflux. Clin Otolaryngol. 2021;46(1):189–95.

Article  PubMed  Google Scholar 

Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice. 2002;16(2):274–7.

Article  PubMed  Google Scholar 

Fernandez AM, Chan WW. Update on extraesophageal manifestations of gastroesophageal reflux. Curr. 2024;40(4):305–13.

Google Scholar 

Morice D, Elhassan HA, Myint-Wilks L, Barnett RE, Rasheed A, Collins H, et al. Laryngopharyngeal reflux: is laparoscopic fundoplication an effective treatment? Ann R Coll Surg Engl. 2022;104(2):79–87.

Article  PubMed  PubMed Central  Google Scholar 

Sidwa F, Moore AL, Alligood E, Fisichella PM. Surgical treatment of extraesophageal manifestations of gastroesophageal reflux disease. World J Surg. 2017;41(10):2566–71.

Article  PubMed  Google Scholar 

Lien HC, Wang CC, Liang WM, Sung FC, Hsu JY, Yeh HZ, et al. Composite pH predicts Esomeprazole response in laryngopharyngeal reflux without typical reflux syndrome. Laryngoscope. 2013;123(6):1483–9.

Article  CAS  PubMed  Google Scholar 

Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.

Article  PubMed  PubMed Central  Google Scholar 

McDonagh M, Peterson K, Raina P, Chang S, Shekelle P. Tool to Assess Risk of Bias in Cohort Studies developed by the Clarity Group and Evidence Partners 2013 [Available from: https://www.ncbi.nlm.nih.gov/books/NBK126701

Foote AG, Thibeault SL. Sensory innervation of the larynx and the search for mucosal mechanoreceptors. J Speech Lang Hear Res. 2021;64(2):371–91.

Article  PubMed  PubMed Central  Google Scholar 

Kastelik JA, Redington AE, Aziz I, Buckton GK, Smith CM, Dakkak M, et al. Abnormal oesophageal motility in patients with chronic cough. Thorax. 2003;58(8):699–702.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rickenbacher N, Kötter T, Kochen MM, Scherer M, Blozik E. Fundoplication versus medical management of gastroesophageal reflux disease: systematic review and meta-analysis. Surg Endosc. 2014;28(1):143–55.

Article  PubMed  Google Scholar 

Du X, Hu Z, Yan C, Zhang C, Wang Z, Wu J. A meta-analysis of long follow-up outcomes of laparoscopic Nissen (total) versus toupet (270°) fundoplication for gastro-esophageal reflux disease based on randomized controlled trials in adults. BMC Gastroenterol. 2016;16(1):88.

Article  PubMed  PubMed Central  Google Scholar 

Broeders JA, Mauritz FA, Ahmed Ali U, Draaisma WA, Ruurda JP, Gooszen HG, et al. Systematic review and meta-analysis of laparoscopic Nissen (posterior total) versus toupet (posterior partial) fundoplication for gastro-oesophageal reflux disease. Br J Surg. 2010;97(9):1318–30.

Article  CAS  PubMed  Google Scholar 

Falk GL, Gooley SC, Church NG, Rangiah DS. How effective is the control of laryngopharyngeal reflux symptoms by fundoplication? Symptom score analysis. Eur Surg - Acta Chir Austriaca. 2020;52(3):123–6.

Article  Google Scholar 

Ratnasingam D, Irvine T, Thompson SK, Watson DI. Laparoscopic antireflux surgery in patients with throat symptoms: a word of caution. World J Surg. 2011;35(2):342–8.

Article  PubMed  Google Scholar 

Catania RA, Kavic SM, Roth JS, Lee TH, Meyer T, Fantry GT, et al. Laparoscopic Nissen fundoplication effectively relieves symptoms in patients with laryngopharyngeal reflux. J Gastrointest Surg. 2007;11(12):1579–87. discussion 87– 8.

Article  PubMed  Google Scholar 

Kaufman JA, Houghland JE, Quiroga E, Cahill M, Pellegrini CA, Oelschlager BK. Long-term outcomes of laparoscopic antireflux surgery for gastroesophageal reflux disease (GERD)-related airway disorder. Surg Endosc. 2006;20(12):1824–30.

Article  CAS  PubMed  Google Scholar 

Suzuki T, Seki Y, Matsumura T, Arai M, Hanazawa T, Okamoto Y, et al. Reflux-related extraesophageal symptoms until proven otherwise: A direct measurement of abnormal proximal exposure based on hypopharyngeal multichannel intraluminal impedance as a reliable Indicator for successful treatment outcomes. J Neurogastroenterol Motil. 2022;28(1):69–77.

Article  PubMed  PubMed Central  Google Scholar 

Aiolfi A, Cavalli M, Saino G, Khor D, Sozzi A, Rausa E, et al. Laparoscopic toupet fundoplication for the treatment of laryngopharyngeal reflux: results at Medium-Term follow-Up. World J Surg. 2020;44(11):3821–8.

Article  PubMed  Google Scholar 

Ward MA, Ebrahim A, Kopita J, Arviso L, Ogola GO, Buckmaster B, et al. Magnetic sphincter augmentation is an effective treatment for atypical symptoms caused by gastroesophageal reflux disease. Surg Endosc. 2020;34(11):4909–15.

Article  PubMed  Google Scholar 

Nikolic M, Matic A, Feka J, Gensthaler L, Kristo I, Osmokrovic B, et al. Expanded indication for magnetic sphincter augmentation: outcomes in weakly acidic reflux compared to standard GERD patients. J Gastrointest Surg. 2022;26(3):532–41.

Article  PubMed  Google Scholar 

Sui X, Deng C, Wang L, Li D, Chen S, Zhang B, et al. Medium-term clinical efficacy of endoscopic antireflux mucosectomy on laryngopharyngeal reflux: a retrospective multicenter cohort study. Gastrointest Endosc. 2023;98(6):893–900.

Article  PubMed  Google Scholar 

Desjardin M, Roman S, Des Varannes SB, Gourcerol G, Coffin B, Ropert A, et al. Pharyngeal pH alone is not reliable for the detection of pharyngeal reflux events:a study with oesophageal and pharyngeal pH-impedance monitoring. United Eur Gastroenterol. 2013;1(6):438–44.

Article  Google Scholar 

Lee Y, Tahir U, Tessier L, Yang K, Hassan T, Dang J, et al. Long-term outcomes following dor, toupet, and Nissen fundoplication: a network meta-analysis of randomized controlled trials. Surg Endosc. 2023;37(7):5052–64.

Article