Rumpret, M. et al. Functional categories of immune inhibitory receptors. Nat. Rev. Immunol. 20, 771–780 (2020).
Article CAS PubMed Google Scholar
Ribas, A. & Wolchok, J. D. Cancer immunotherapy using checkpoint blockade. Science 359, 1350–1355 (2018).
Article CAS PubMed PubMed Central Google Scholar
Grebinoski, S. & Vignali, D. A. Inhibitory receptor agonists: the future of autoimmune disease therapeutics? Curr. Opin. Immunol. 67, 1–9 (2020).
Article CAS PubMed PubMed Central Google Scholar
Singh, A. et al. A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets. eLife 13, RP92870 (2024).
Article PubMed PubMed Central Google Scholar
Rumpret, M., von Richthofen, H. J., Peperzak, V. & Meyaard, L. Inhibitory pattern recognition receptors. J. Exp. Med. 219, e20211463 (2022).
Article CAS PubMed Google Scholar
Kumawat, K. et al. LAIR-1 limits neutrophilic airway inflammation. Front. Immunol. 10, 842 (2019).
Article CAS PubMed PubMed Central Google Scholar
Helou, D. G. et al. LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity. J. Allergy Clin. Immunol. 149, 223–236.e6 (2022). This paper uses mouse in vivo assays, signalling read-outs and ex vivo human cells to study how LAIR1 regulates type 2 innate lymphoid cells in airway hyperreactivity.
Article CAS PubMed Google Scholar
Carvalheiro, T. et al. Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis. J. Autoimmun. 146, 103219 (2024).
Article CAS PubMed Google Scholar
Kim, S. et al. The role of leukocyte-associated Ig-like receptor-1 in suppressing collagen-induced arthritis. J. Immunol. 199, 2692–2700 (2017).
Article CAS PubMed Google Scholar
Myers, L. K. et al. 1,25-Dihydroxyvitamin D3 and 20-hydroxyvitamin D3 upregulate LAIR-1 and attenuate collagen induced arthritis. Int. J. Mol. Sci. 22, 13342 (2021).
Article CAS PubMed PubMed Central Google Scholar
Carroll, K. R. et al. Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression. Nat. Immunol. 25, 671–681 (2024). This paper emphasizes HMGB1–RAGE and C1q–LAIR-1 interactions as key pathways in the microglial–neuronal interplay that determines the balance between physiological and maladaptive states.
Article CAS PubMed PubMed Central Google Scholar
Camargo, C. M., Augusto, D. G. & Petzl-Erler, M. L. Differential gene expression levels might explain association of LAIR2 polymorphisms with pemphigus. Hum. Genet. 135, 233–244 (2016).
Article CAS PubMed Google Scholar
Farias, T. D. J., Augusto, D. G., de Almeida, R. C., Malheiros, D. & Petzl-Erler, M. L. Screening the full leucocyte receptor complex genomic region revealed associations with pemphigus that might be explained by gene regulation. Immunology 156, 86–93 (2019).
Article CAS PubMed Google Scholar
Diaz-Pena, R. et al. A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis. Ann. Rheum. Dis. 71, 714–717 (2012).
Article CAS PubMed Google Scholar
Simone, R. et al. Serum LAIR-2 is increased in autoimmune thyroid diseases. PLoS One 8, e63282 (2013).
Article CAS PubMed PubMed Central Google Scholar
Elsayed, O. M., Abdelazim, S. A., Darwish, H. A., Shaker, O. G. & Senousy, M. A. Association of LncRNA–PAX8–AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism. Sci. Rep. 13, 6 (2023).
Article CAS PubMed PubMed Central Google Scholar
Flies, D. B., Langermann, S., Jensen, C., Karsdal, M. A. & Willumsen, N. Regulation of tumor immunity and immunotherapy by the tumor collagen extracellular matrix. Front. Immunol. 14, 1199513 (2023).
Article CAS PubMed PubMed Central Google Scholar
Chang, Y. C. & Nizet, V. The interplay between Siglecs and sialylated pathogens. Glycobiology 24, 818–825 (2014).
Article CAS PubMed PubMed Central Google Scholar
Yang, T. et al. LILRB4, an immune checkpoint on myeloid cells. Blood Sci. 4, 49–56 (2022).
Article PubMed PubMed Central Google Scholar
Wang, Y. et al. Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors. Cell Rep. Med. 5, 101374 (2024).
Article CAS PubMed PubMed Central Google Scholar
Meyaard, L. et al. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity 7, 283–290 (1997).
Article CAS PubMed Google Scholar
Wende, H., Volz, A. & Ziegler, A. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. Immunogenetics 51, 703–713 (2000).
Article CAS PubMed Google Scholar
Lebbink, R. J. et al. Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1. J. Exp. Med. 203, 1419–1425 (2006).
Article CAS PubMed PubMed Central Google Scholar
Lebbink, R. J. et al. Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III. Matrix Biol. 28, 202–210 (2009).
Article CAS PubMed Google Scholar
Son, M., Santiago-Schwarz, F., Al-Abed, Y. & Diamond, B. C1q limits dendritic cell differentiation and activation by engaging LAIR-1. Proc. Natl Acad. Sci. USA 109, E3160–E3167 (2012).
Article CAS PubMed PubMed Central Google Scholar
Olde Nordkamp, M. J. et al. Inhibition of the classical and lectin pathway of the complement system by recombinant LAIR-2. J. Innate Immun. 6, 284–292 (2014).
Article CAS PubMed Google Scholar
Olde Nordkamp, M. J. et al. Leukocyte-associated Ig-like receptor-1 is a novel inhibitory receptor for surfactant protein D. J. Leukoc. Biol. 96, 105–111 (2014).
Keerthivasan, S. et al. Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1. Immunity 54, 1511–1526.e8 (2021). This work identifies a new ligand for LAIR1 and shows that LAIR1 regulates homeostatic pathways in macrophages, which affects tumour immunity.
Article CAS PubMed Google Scholar
Zhang, Y. S. et al. Adiponectin’s globular domain inhibits T cell activation by interacting with LAIR-1. Biochem. Biophys. Res. Commun. 573, 117–124 (2021).
Article CAS PubMed Google Scholar
Tang, X. B. et al. A single residue, arginine 65, is critical for the functional interaction of leukocyte-associated inhibitory receptor-1 with collagens. J. Immunol. 182, 5446–5452 (2009).
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