Cancer screening in patients with acromegaly: a plea for a personalized approach and international registries

Melmed S. Pituitary-tumor endocrinopathies. N Engl J Med. 2020;382(10):937–50. https://doi.org/10.1056/NEJMra1810772.

Article  CAS  PubMed  Google Scholar 

Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S. Acromegaly: pathogenesis, diagnosis, and management. Lancet Diabetes Endocrinol. 2022;10(11):804–26. https://doi.org/10.1016/S2213-8587(22)00244-3.

Article  CAS  PubMed  Google Scholar 

Burton T, Le Nestour E, Neary M, Ludlam WH. Incidence and prevalence of acromegaly in a large US health plan database. Pituitary. 2016;19(3):262–7. https://doi.org/10.1007/s11102-015-0701-2.

Article  PubMed  PubMed Central  Google Scholar 

Crisafulli S, Luxi N, Sultana J, Fontana A, Spagnolo F, Giuffrida G, Ferraù F, Gianfrilli D, Cozzolino A, Cristina De Martino M, Gatto F, Barone-Adesi F, Cannavò S, Trifirò G. Global epidemiology of acromegaly: a systematic review and meta-analysis. Eur J Endocrinol. 2021;185(2):251–63. https://doi.org/10.1530/EJE-21-0216.

Article  CAS  PubMed  Google Scholar 

Matsubayashi K, Kawakami K. Prevalence, incidence, comorbidities, and treatment patterns among Japanese patients with acromegaly: a descriptive study using a nationwide claims database. Endocr J. 2020;67(10):997–1006. https://doi.org/10.1507/endocrj.EJ20-0129.

Article  PubMed  Google Scholar 

Lavrentaki A, Paluzzi A, Wass JA, Karavitaki N. Epidemiology of acromegaly: review of population studies. Pituitary. 2017;20(1):4–9. https://doi.org/10.1007/s11102-016-0754-x.

Article  PubMed  Google Scholar 

Park KH, Lee EJ, Seo GH, Ku CR. Risk for Acromegaly-related Comorbidities by Sex in Korean Acromegaly. J Clin Endocrinol Metab. 2020;105(4):dgz17. https://doi.org/10.1210/clinem/dgz317.

Article  Google Scholar 

Bolfi F, Neves AF, Boguszewski CL, Nunes-Nogueira VS. Mortality in acromegaly decreased in the last decade: a systematic review and meta-analysis. Eur J Endocrinol. 2018;179(1):59–71. https://doi.org/10.1530/EJE-18-0255.

Article  CAS  PubMed  Google Scholar 

Holdaway IM, Rajasoorya RC, Gamble GD. Factors influencing mortality in acromegaly. J Clin Endocrinol Metab. 2004;89(2):667–74. https://doi.org/10.1210/jc.2003-031199.

Article  CAS  PubMed  Google Scholar 

Melmed S, Kaiser UB, Lopes MB, Bertherat J, Syro LV, Raverot G, Reincke M, JohannssonBeckers GA, Fleseriu M, Giustina A, Wass JAH, Ho KKY. Clinical biology of the pituitary adenoma. Endocr Rev. 2022;43(6):1003–37. https://doi.org/10.1210/endrev/bnac010.

Article  PubMed  PubMed Central  Google Scholar 

Ritvonen E, Löyttyniemi E, Jaatinen P, Ebeling T, Moilanen L, Nuutila P, Kauppinen-Mäkelin R, Schalin-Jäntti C. Mortality in acromegaly: a 20-year follow-up study. Endocr Relat Cancer. 2016;23(6):469–80. https://doi.org/10.1530/ERC-16-0106.

Article  CAS  PubMed  Google Scholar 

Giustina A, Biermasz N, Casanueva FF, Fleseriu M, Mortini P, Strasburger C, van der Lely AJ, Wass J, Melmed S; Acromegaly Consensus Group. Consensus on criteria for acromegaly diagnosis and remission. Pituitary. 2024 Feb;27(1):7–22. https://doi.org/10.1007/s11102-023-01360-1. Epub 2023 Nov 3. Erratum in: Pituitary. 2024 Feb;27(1):88. https://doi.org/10.1007/s11102-023-01373-w.

Amodru V, Sahakian N, Piazzola C, Appay R, Graillon T, Cuny T, Morange I, Albarel F, Vermalle M, Regis J, Dufour H, Brue T, Castinetti F. Changes in multi-modality management of acromegaly in a tertiary centre over 2 decades. Pituitary. 2024;27(3):294–302. https://doi.org/10.1007/s11102-024-01387-y.

Article  CAS  PubMed  Google Scholar 

Gadelha MR, Kasuki L, Lim DST, Fleseriu M. Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update. Endocr Rev. 2019;40(1):268–332. https://doi.org/10.1210/er.2018-00115.

Article  PubMed  Google Scholar 

Ghajar A, Jones PS, Guarda FJ, Faje A, Tritos NA, Miller KK, Swearingen B, Nachtigall LB. Biochemical control in acromegaly with multimodality therapies: outcomes from a pituitary center and changes over time. J Clin Endocrinol Metab. 2020;105(3):e532–43. https://doi.org/10.1210/clinem/dgz187.

Article  PubMed  Google Scholar 

Nachtigall L, Delgado A, Swearingen B, Lee H, Zerikly R, Klibanski A. Changing patterns in diagnosis and therapy of acromegaly over two decades. J Clin Endocrinol Metab. 2008;93(6):2035–41. https://doi.org/10.1210/jc.2007-2149.

Article  CAS  PubMed  Google Scholar 

Ioachimescu AG, Handa T, Goswami N, Pappy AL 2nd, Veledar E, Oyesiku NM. Gender differences and temporal trends over two decades in acromegaly: a single center study in 112 patients. Endocrine. 2020;67(2):423–32. https://doi.org/10.1007/s12020-019-02123-4.

Article  CAS  PubMed  Google Scholar 

Renehan AG, Zwahlen M, Minder C, O’Dwyer ST, Shalet SM, Egger M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet. 2004;363(9418):1346–53. https://doi.org/10.1016/S0140-6736(04)16044-3.

Article  CAS  PubMed  Google Scholar 

Danilowicz K, Sosa S. Acromegaly and cancer: an update. Arch Med Res. 2023;54(8): 102914. https://doi.org/10.1016/j.arcmed.2023.102914.

Article  CAS  PubMed  Google Scholar 

Freda PU, Bruce JN, Jin Z, Kostadinov J, Khandji AG, Cremers S, Post KD. Prospective, longitudinal study of cancer predictors and rates in a New York City cohort of 598 patients with acromegaly. J Clin Endocrinol Metab. 2024;10:dgae469. https://doi.org/10.1210/clinem/dgae469.

Article  Google Scholar 

Petroff D, Tönjes A, Grussendorf M, Droste M, Dimopoulou C, Stalla G, Jaursch-Hancke C, Mai M, Schopohl J, Schöfl C. The incidence of cancer among acromegaly patients: results from the German acromegaly registry. J Clin Endocrinol Metab. 2015;100(10):3894–902. https://doi.org/10.1210/jc.2015-2372.

Article  CAS  PubMed  Google Scholar 

Mestron A, Webb SM, Astorga R, Benito P, Catala M, Gaztambide S, Gomez JM, Halperin I, Lucas-Morante T, Moreno B, Obiols G, de Pablos P, Paramo C, Pico A, Torres E, Varela C, Vazquez JA, Zamora J, Albareda M, Gilabert M. Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA). Eur J Endocrinol. 2004;151(4):439–46. https://doi.org/10.1530/eje.0.1510439.

Article  CAS  PubMed  Google Scholar 

Maione L, Brue T, Beckers A, Delemer B, Petrossians P, Borson-Chazot F, Chabre O, François P, Bertherat J, Cortet-Rudelli C, Chanson P, French Acromegaly Registry Group. Changes in the management and comorbidities of acromegaly over three decades: the French Acromegaly Registry. Eur J Endocrinol. 2017;176(5):645–55. https://doi.org/10.1530/EJE-16-1064.

Article  CAS  PubMed  Google Scholar 

Guevara-Aguirre J, Peña G, Acosta W, Pazmiño G, Saavedra J, Soto L, Lescano D, Guevara A, Gavilanes AWD. Cancer in growth hormone excess and growth hormone deficit. Endocr Relat Cancer. 2023;30(10): e220402. https://doi.org/10.1530/ERC-22-0402.

Article  CAS  PubMed  Google Scholar 

Melmed S. Acromegaly and cancer: not a problem? J Clin Endocrinol Metab. 2001;86(7):2929–34. https://doi.org/10.1210/jcem.86.7.7635.

Article  CAS  PubMed  Google Scholar 

Maione L, Chanson P. National acromegaly registries. Best Pract Res Clin Endocrinol Metab. 2019;33(2): 101264. https://doi.org/10.1016/j.beem.2019.02.001.

Article  PubMed  Google Scholar 

Găloiu S, Toma ID, Tănasie DI, Bărbulescu A, Baciu I, Niculescu DA, Trifănescu RA, Căpăţînă C, Radian Ş, Poiană C. High mortality risk among women with acromegaly still persists. Front Endocrinol (Lausanne). 2024;21(15):1348972. https://doi.org/10.3389/fendo.2024.1348972.

Article  Google Scholar 

Giustina A, Barkhoudarian G, Beckers A, Ben-Shlomo A, Biermasz N, Biller B, Boguszewski C, Bolanowski M, Bollerslev J, Bonert V, Bronstein MD, Buchfelder M, Casanueva F, Chanson P, Clemmons D, Fleseriu M, Formenti AM, Freda P, Gadelha M, Geer E, Gurnell M, Heaney AP, Ho KKY, Ioachimescu AG, Lamberts S, Laws E, Losa M, Maffei P, Mamelak A, Mercado M, Molitch M, Mortini P, Pereira AM, Petersenn S, Post K, Puig-Domingo M, Salvatori R, Samson SL, Shimon I, Strasburger C, Swearingen B, Trainer P, Vance ML, Wass J, Wierman ME, Yuen KCJ, Zatelli MC, Melmed S. Multidisciplinary management of acromegaly: A consensus. Rev Endocr Metab Disord. 2020;21(4):667–78. https://doi.org/10.1007/s11154-020-09588-z.

Article  PubMed  PubMed Central  Google Scholar 

Brue T, Rahabi H, Barry A, Barlier A, Bertherat J, Borson-Chazot F, Castinetti F, Cazabat L, Chabre O, Chevalier N, Christin-Maitre S, Cortet

Comments (0)

No login
gif