Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, et al. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol. 2017;3:1335–42. https://doi.org/10.1001/jamaoncol.2017.0589.
Article PubMed PubMed Central Google Scholar
Sultana Q, Kar J, Verma A, Sanghvi S, Kaka N, Patel N, et al. A comprehensive review on neuroendocrine neoplasms: presentation, pathophysiology and management. J Clin Med. 2023;12:5138. https://doi.org/10.3390/jcm12155138.
Article CAS PubMed PubMed Central Google Scholar
Associazione Italiana di Oncologia Medica (AIOM). Linee guida per la diagnosi e il trattamento delle neoplasie neuroendocrine(Rapporto n. 311). 2021. https://www.iss.it/documents/20126/8403839/LG-311-Neoplasie-Neuroendocrine_agg2022
American Diabetes Association Professional Practice Committee. 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2024. Diabetes Care. 2024;47(Suppl 1):S20-S42. https://doi.org/10.2337/dc24-S002.
Vergès B, Cariou B. mTOR inhibitors and diabetes. Diabetes Res Clin Pract. 2015;110:101–8. https://doi.org/10.1016/j.diabres.2015.09.014.
Article CAS PubMed Google Scholar
Gallo M, Ruggeri RM, Muscogiuri G, Pizza G, Faggiano A, Colao A. Diabetes and pancreatic neuroendocrine tumours: Which interplays, if any? Cancer Treat Rev. 2018;67:1–9. https://doi.org/10.1016/j.ctrv.2018.04.013.
Natalicchio A, Faggiano A, Zatelli MC, Argentiero A, D’Oronzo S, Marrano N, et al. Metabolic disorders and gastroenteropancreatic-neuroendocrine tumors (GEP-NETs): How do they influence each other? An Italian Association of Medical Oncology (AIOM)/ Italian Association of Medical Diabetologists (AMD)/ Italian Society of Endocrinology (SIE)/ Italian Society of Pharmacology (SIF) multidisciplinary consensus position paper. Crit Rev Oncol Hematol. 2022;169:103572. https://doi.org/10.1016/j.critrevonc.2021.103572.
Vitale G, Gaudenzi G, Oldani M, Pandozzi C, Filice A, Jaafar S, et al. Nutritional status and gastroenteropancreatic neuroendocrine neoplasms: lights and shadows with a clinical guide from the NIKE Group. Rev Endocr Metab Disord. 2024. https://doi.org/10.1007/s11154-024-09937-2.
Kusne YN, Kosiorek HE, Buras MR, Verona PM, Coppola KE, Rone KA, et al. Implications of neuroendocrine tumor and diabetes mellitus on patient outcomes and care: a matched case–control study. Future Sci OA. 2021;7. https://doi.org/10.2144/fsoa-2020-0190.
Resmini E, Minuto F, Colao A, Ferone D. Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities. Acta Diabetol. 2009;46:85–95. https://doi.org/10.1007/s00592-009-0112-9.
Article CAS PubMed Google Scholar
Halfdanarson TR, Bamlet WR, McWilliams RR, Hobday TJ, Burch PA, Rabe KG, et al. Risk factors for pancreatic neuroendocrine tumors: a clinic-based case-control study. Pancreas. 2014;43:1219–22. https://doi.org/10.1097/MPA.0000000000000234.
Article CAS PubMed PubMed Central Google Scholar
Feola T, Puliani G, Sesti F, Modica R, Centello R, Minotta R, et al. Risk factors for gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): a three-centric case-control study. J Endocrinol Invest. 2022;45:849–57. https://doi.org/10.1007/s40618-021-01715-0.
Article CAS PubMed Google Scholar
Haugvik S-P, Hedenström P, Korsæth E, Valente R, Hayes A, Siuka D, et al. Diabetes, smoking, alcohol use, and family history of cancer as risk factors for pancreatic neuroendocrine tumors: a systematic review and meta-analysis. Neuroendocrinology. 2015;101:133–42. https://doi.org/10.1159/000375164.
Article CAS PubMed Google Scholar
Leoncini E, Carioli G, La Vecchia C, Boccia S, Rindi G. Risk factors for neuroendocrine neoplasms: a systematic review and meta-analysis. Ann Oncol. 2016;27:68–81. https://doi.org/10.1093/annonc/mdv505.
Article CAS PubMed Google Scholar
Natalicchio A, Marrano N, Montagnani M, Gallo M, Faggiano A, Zatelli M, et al. Glycemic control and cancer outcomes in oncologic patients with diabetes: an Italian Association of Medical Oncology (AIOM), Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology (SIE), Italian Society of Pharmacology (SIF) multidisciplinary critical view. J Endocrinol Invest. 2024. https://doi.org/10.1007/s40618-024-02417-z.
Article PubMed PubMed Central Google Scholar
Vernieri C, Casola S, Foiani M, Pietrantonio F, de Braud F, Longo V. Targeting cancer metabolism: dietary and pharmacologic interventions. Cancer Discov. 2016;6:1315–33. https://doi.org/10.1158/2159-8290.CD-16-0615.
Article CAS PubMed PubMed Central Google Scholar
Capurso G, Falconi M, Panzuto F, Rinzivillo M, Boninsegna L, Bettini R, et al. Risk factors for sporadic pancreatic endocrine tumors. Am J Gastroenterol. 2009;104:3034–41. https://doi.org/10.1038/ajg.2009.466.
Article CAS PubMed Google Scholar
Pusceddu S, Vernieri C, Di Maio M, Marconcini R, Spada F, Massironi S, et al. Metformin use is associated with longer progression-free survival of patients with diabetes and pancreatic neuroendocrine tumors receiving everolimus and/or somatostatin analogues. Gastroenterology. 2018;155:479-489.e7. https://doi.org/10.1053/j.gastro.2018.04.010.
Article CAS PubMed Google Scholar
Garg SK, Shah VN. Newer therapies for diabetes management. Diabetes Technol Ther. 2014;16(Suppl 1):S119–27. https://doi.org/10.1089/dia.2014.1514.
Nauck MA, Quast DR, Wefers J, Meier JJ. GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art. Mol Metab. 2021;46:101102. https://doi.org/10.1016/j.molmet.2020.101102.
Article CAS PubMed Google Scholar
Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB, et al. LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept. Mol Metab. 2018;18:3–14. https://doi.org/10.1016/j.molmet.2018.09.009.
Article CAS PubMed PubMed Central Google Scholar
Brubaker PL, Drucker DJ. Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology. 2004;145:2653–9. https://doi.org/10.1210/en.2004-0015.
Article CAS PubMed Google Scholar
Marrano N, Biondi G, Cignarelli A, Perrini S, Laviola L, Giorgino F, et al. Functional loss of pancreatic islets in type 2 diabetes: How can we halt it? Metabolism. 2020;110:154304. https://doi.org/10.1016/j.metabol.2020.154304.
Article CAS PubMed Google Scholar
Bugliani M, Syed F, Paula FMM, Omar BA, Suleiman M, Mossuto S, et al. DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes. Mol Cell Endocrinol. 2018;473:186–93. https://doi.org/10.1016/j.mce.2018.01.019.
Article CAS PubMed Google Scholar
Drucker DJ. Glucagon-like peptide-1 and the Islet β-cell: augmentation of cell proliferation and inhibition of apoptosis. Endocrinology. 2003;144:5145–8. https://doi.org/10.1210/en.2003-1147.
Article CAS PubMed Google Scholar
Buteau J, Roduit R, Susini S, Prentki M. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia. 1999;42:856–64. https://doi.org/10.1007/s001250051238.
Article CAS PubMed Google Scholar
Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes. 1999;48:2270–6. https://doi.org/10.2337/diabetes.48.12.2270.
Article CAS PubMed Google Scholar
Perfetti R, Zhou J, Doyle ME, Egan JM. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, Glucose-Intolerant Rats. Endocrinology. 2000;141:4600–5. https://doi.org/10.1210/endo.141.12.7806.
Article CAS PubMed Google Scholar
Farilla L, Hui H, Bertolotto C, Kang E, Bulotta A, Di Mario U, et al. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in zucker diabetic rats. Endocrinology. 2002;143:4397–408. https://doi.org/10.1210/en.2002-220405.
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