Sautner D, Saeger W, Lüdecke DW (1993) Tumors of the Sellar region mimicking pituitary adenomas. Exp Clin Endocrinol Diabetes 101(05):283–289
Clayton RN (1999) Sporadic pituitary tumours: from epidemiology to use of databases. Best Pract Res Clin Endocrinol Metab 13(3):451–460
Colao A (2009) The prolactinoma. Best Pract Res Clin Endocrinol Metab 23(5):575–596
Article CAS PubMed Google Scholar
Pinzone JJ, Katznelson L, Danila DC, Pauler DK, Miller CS, Klibanski A (2000) Primary medical therapy of micro-and macroprolactinomas in men. J Clin Endocrinol Metabolism 85(9):3053–3057
Mindermann T, Wilson CB (1994) Age-related and gender‐related occurrence of pituitary adenomas. Clin Endocrinol 41(3):359–364
Vaneckova M, Seidl Z, Hana V, Jarkovska Z (2007) Macroprolactinomas: retrospective follow up study in the MR imaging and correlation with clinical symptomatology. Neuroendocrinol Lett 28(6):841–845
Klibanski A, Zervas NT (1991) Diagnosis and management of hormone-secreting pituitary adenomas. N Engl J Med 324(12):822–831
Article CAS PubMed Google Scholar
Vilar L, Freitas MC, Naves LA, Casulari LA, Azevedo M, Montenegro R, Bronstein MD (2008) Diagnosis and management of hyperprolactinemia: results of a Brazilian multicenter study with 1234 patients. J Endocrinol Investig 31(5):436–444
Colao A, Somma CD, Lombardi G, Pivonello R, Sarno AD (2002) Dopamine receptor agonists for treating prolactinomas. Expert Opin Investig Drugs 11(6):787–800
Article CAS PubMed Google Scholar
Di Sarno A, Landi ML, Cappabianca P, Di Salle F, Rossi FW, Pivonello R, Colao A (2001) Resistance to Cabergoline as compared with Bromocriptine in hyperprolactinemia: prevalence, clinical definition, and therapeutic strategy. J Clin Endocrinol Metabolism 86(11):5256–5261
Gillam MP, Molitch ME, Lombardi G, Colao A (2006) Advances in the treatment of prolactinomas. Endocr Rev 27(5):485–534
Article CAS PubMed Google Scholar
Kars M, Pereira AM, Bax JJ, Romijn JA (2008) Cabergoline and cardiac valve disease in prolactinoma patients: additional studies during long-term treatment are required. Eur J Endocrinol 159(4):363
Article CAS PubMed Google Scholar
Greenman Y, Tordjman K, Stern N (1998) Increased body weight associated with prolactin secreting pituitary adenomas: weight loss with normalization of prolactin levels. Clin Endocrinol 48(5):547–553
Goede DL, Hauser RS (2006) Increased prevalence of high Body Mass Index in patients presenting with pituitary tumours: severe obesity in patients with macroprolactinoma. Swiss medical weekly, 136(1516)
Al Sabie F, Tariq Z, Erickson D, Donegan D (2021) Association between prolactinoma and body mass index. Endocr Pract 27(4):312–317
Pereira-Lima JFS, Leães CGS, Neto FMF, Barbosa MV, Silva AL, Oliveira MD (2013) Hyperprolactinemia and body weight: prevalence of obesity and overweight in patients with hyperprolactinemia. Res J Endocrinol Metab 1(1):2
Doknic M, Pekic S, Zarkovic M, Medic-Stojanoska M, Dieguez C, Casanueva F, Popovic V (2002) Dopaminergic tone and obesity: an insight from prolactinomas treated with Bromocriptine. Eur J Endocrinol 147(1):77–84
Article CAS PubMed Google Scholar
Southon A, Walder K, Sanigorski AM, Zimmet P, Nicholson GC, Kotowicz MA, Collier G (2003) The Taq IA and Ser311 Cys polymorphisms in the dopamine D2 receptor gene and obesity. Diabetes Nutr Metab 16(1):72–76
Athanasoulia AP, Sievers C, Uhr M, Ising M, Stalla GK, Schneider HJ (2014) The effect of the ANKK1/DRD2 Taq1A polymorphism on weight changes of dopaminergic treatment in prolactinomas. Pituitary 17(3):240–245
Article CAS PubMed Google Scholar
Pirchio R, Graziadio C, Colao A, Pivonello R, Auriemma RS (2022) Metabolic effects of prolactin. Front Endocrinol 13:1015520
Kirsch P, Kunadia J, Shah S, Agrawal N (2022) Metabolic effects of prolactin and the role of dopamine agonists: A review. Front Endocrinol 13:1002320
Chien HY, Chen SM, Li WC (2023) Dopamine receptor agonists mechanism of actions on glucose Lowering and their connections with prolactin actions. Front Clin Diabetes Healthc 4:935872
Article PubMed PubMed Central Google Scholar
Ali M, Mirza L (2021) Morbid obesity due to prolactinoma and significant weight loss after dopamine agonist treatment. AACE Clin Case Rep 7(3):204–206
Article CAS PubMed PubMed Central Google Scholar
Berinder K, Nyström T, Höybye C, Hall K, Hulting AL (2011) Insulin sensitivity and lipid profile in prolactinoma patients before and after normalization of prolactin by dopamine agonist therapy. Pituitary 14(3):199–207
Article CAS PubMed Google Scholar
Pala NA, Laway BA, Misgar RA, Dar RA (2015) Metabolic abnormalities in patients with prolactinoma: response to treatment with Cabergoline. Diabetol Metab Syndr 7(1):1–6
Byberg S, Futtrup J, Andreassen M, Krogh J (2019) Metabolic effects of dopamine agonists in patients with prolactinomas: a systematic review and meta-analysis. Endocr Connections 8(10):1395–1404
Santos-Silva CM, Barbosa FR, Lima GA, Warszawski L, Fontes R, Domingues RC, Gadelha MR (2011) BMI and metabolic profile in patients with prolactinoma before and after treatment with dopamine agonists. Obesity 19(4):800–805
Gibson CD, Karmally W, McMahon DJ, Wardlaw SL, Korner J (2012) Randomized pilot study of Cabergoline, a dopamine receptor agonist: effects on body weight and glucose tolerance in obese adults. Diabetes Obes Metabolism 14(4):335–340
Soran H, Wilding J, MacFarlane I (2004) Body weight and prolactinoma: a retrospective study. Int J Obes 28(1):183–183
Yermus R, Ezzat S (2002) Does normalization of prolactin levels result in weight loss in patients with prolactin secreting pituitary adenomas? Clin Endocrinol 56(4):562–562
Delgrange E, Donckier J, Maiter D (1999) Hyperprolactinaemia as a reversible cause of weight gain in male patients? Clin Endocrinol 50(2):271
Ben-Jonathan N, Hnasko R (2001) Dopamine as a prolactin (PRL) inhibitor. Endocr Rev 22(6):724–763
Article CAS PubMed Google Scholar
Wang GJ, Volkow ND, Logan J, Pappas NR, Wong CT, Zhu W,… Fowler,JS (2001). Brain dopamine and obesity. The Lancet, 357(9253), 354–357.
Shibli-Rahhal A, Schlechte J (2009) The effects of hyperprolactinemia on bone and fat. Pituitary 12(2):96–104
Article CAS PubMed Google Scholar
Bina KG, Cincotta AH (2000) Dopaminergic agonists normalize elevated hypothalamic neuropeptide Y and corticotropin-releasing hormone, body weight gain, and hyperglycemia in Ob/ob mice. Neuroendocrinology 71(1):68–78
Article CAS PubMed Google Scholar
Cincotta AH, Meier AH (1989) Reductions of body fat stores and total plasma cholesterol and triglyceride concentrations in several species by Bromocriptine treatment. Life Sci 45(23):2247–2254
Article CAS PubMed Google Scholar
Folgueira, C., Beiroa, D., Porteiro, B., Duquenne, M., Puighermanal, E., Fondevila,M. F.,… Nogueiras, R. (2019). Hypothalamic dopamine signalling regulates brown fat thermogenesis. Nature metabolism, 1(8), 811–829.
Ling C, Svensson L, Odén B, Weijdegård B, Edén B, Edén S, Billig H (2003) Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue. J Clin Endocrinol Metabolism 88(4):1804–1808
Comments (0)