von Bartheld CS, Bahney J, Herculano-Houzel S. The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting. J Comp Neurol. 2016. pp. 3865–95.

Valles SL, Singh SK, Campos-Campos J, Colmena C, Campo-Palacio I, Alvarez-Gamez K et al. Functions of astrocytes under normal conditions and after a brain disease. Int J Mol Sci. 2023.

Pociūtė A, Pivoriūnas A, Verkhratsky A. Astrocytes dynamically regulate the blood-brain barrier in the healthy brain. Neural Regeneration Res. 2024;19.

Chen Z, Yuan Z, Yang S, Zhu Y, Xue M, Zhang J, et al. Brain energy metabolism: astrocytes in neurodegenerative diseases. CNS Neurosci Ther. 2023;29:24–36.

Article  CAS  PubMed  Google Scholar 

Park J, Chung W-S. Astrocyte-dependent circuit remodeling by synapse phagocytosis. Curr Opin Neurobiol. 2023;81:102732.

Article  CAS  PubMed  Google Scholar 

Ponath G, Park C, Pitt D. The role of astrocytes in multiple sclerosis. Front Immunol. 2018;9:217.

Article  PubMed  PubMed Central  Google Scholar 

Xu T, Liu C, Deng S, Gan L, Zhang Z, Yang G-Y, et al. The roles of microglia and astrocytes in Myelin phagocytosis in the central nervous system. J Cereb Blood Flow Metabolism. 2022;43:325–40.

Article  Google Scholar 

Konishi H, Koizumi S, Kiyama H. Phagocytic astrocytes: emerging from the shadows of microglia. Glia. 2022;70:1009–26.

Article  PubMed  PubMed Central  Google Scholar 

Giovannoni F, Quintana FJ. The role of astrocytes in CNS inflammation. Trends Immunol. 2020;41:805–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hasel P, Aisenberg WH, Bennett FC, Liddelow SA. Molecular and metabolic heterogeneity of astrocytes and microglia. Cell Metabol. 2023;35:555–70.

Article  CAS  Google Scholar 

Lo CH, Skarica M, Mansoor M, Bhandarkar S, Toro S, Pitt D. Astrocyte heterogeneity in multiple sclerosis: current Understanding and technical challenges. Front Cell Neurosci. 2021;15:726479.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matias I, Morgado J, Gomes FCA. Astrocyte heterogeneity: impact to brain aging and disease. Front Aging Neurosci. 2019.

Moulson AJ, Squair JW, Franklin RJM, Tetzlaff W, Assinck P. Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity? Frontiers in Cellular Neuroscience. 2021.

Brandebura AN, Paumier A, Onur TS, Allen NJ. Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders. Nat Rev Neurosci. 2023;24:23–39.

Article  CAS  PubMed  Google Scholar 

Kreher C, Favret J, Maulik M, Shin D. Lysosomal functions in glia associated with neurodegeneration. Biomolecules. 2021;11.

Sung K, Jimenez-Sanchez M. Autophagy in astrocytes and its implications in neurodegeneration. J Mol Biol. 2020;432:2605–21.

Article  CAS  PubMed  Google Scholar 

Zhou Z, Zhou J, Liao J, Chen Z, Zheng Y. The emerging role of astrocytic autophagy in central nervous system disorders. Neurochem Res. 2022.

Galloway DA, Phillips AEMM, Owen DRJJ, Moore CS. Phagocytosis in the brain: homeostasis and disease. Front Immunol. 2019;10:790.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J-L, Xu C-J. Astrocytes autophagy in aging and neurodegenerative disorders. Biomed pharmacotherapy = Biomedecine Pharmacotherapie. 2020;122:109691.

Article  CAS  Google Scholar 

Kawai A, Uchiyama H, Takano S, Nakamura N, Ohkuma S. Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells. Autophagy. 2007;3:154–7.

Article  CAS  PubMed  Google Scholar 

Papouin T, Dunphy J, Tolman M, Foley JC, Haydon PG. Astrocytic control of synaptic function. Philosophical Trans Royal Soc Lond Ser B Biol Sci. 2017;372.

Kıray H, Lindsay SL, Hosseinzadeh S, Barnett SC. The multifaceted role of astrocytes in regulating myelination. Exp Neurol. 2016;283:541–9.

Article  PubMed  PubMed Central  Google Scholar 

Lööv C, Mitchell CH, Simonsson M, Erlandsson A. Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification. Glia. 2015;63:1997–2009.

Article  PubMed  PubMed Central  Google Scholar 

Lööv C, Erlandsson A. Lysosomal acidification in cultured astrocytes using nanoparticles. Methods in molecular biology. (Clifton NJ). 2017;1594:165–77.

Google Scholar 

Cox GM, Kithcart AP, Pitt D, Guan Z, Alexander J, Williams JL, et al. Macrophage migration inhibitory factor potentiates Autoimmune-Mediated neuroinflammation. J Immunol. 2013;191:1043–54.

Article  CAS  PubMed  Google Scholar 

Quan L, Uyeda A, Muramatsu R. Central nervous system regeneration: the roles of glial cells in the potential molecular mechanism underlying remyelination. Inflamm Regeneration. 2022;42:7.

Article  Google Scholar 

Kallergi E, Siva Sankar D, Matera A, Kolaxi A, Paolicelli RC, Dengjel J, et al. Profiling of purified autophagic vesicle degradome in the maturing and aging brain. Neuron. 2023;111:2329–e23477.

Article  CAS  PubMed  Google Scholar 

Litwiniuk A, Juszczak GR, Stankiewicz AM, Urbańska K. The role of glial autophagy in Alzheimer’s disease. Mol Psychiatry. 2023;28:4528–39.

Article  CAS  PubMed  Google Scholar 

Mitsui S, Yamaguchi J, Suzuki C, Uchiyama Y, Tanida I. TUNEL-positive structures in activated microglia and SQSTM1/p62-positive structures in activated astrocytes in the neurodegenerative brain of a CLN10 mouse model. Glia. 2023;71:2753–69.

Article  CAS  PubMed  Google Scholar 

Wang T, Sun Y, Dettmer U. Astrocytes in Parkinson’s Disease: From Role to Possible Intervention. Cells. 2023.

Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541:481–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, et al. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive States. Nat Neurosci. 2022;25:1528–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rooney B, Leng K, Mccarthy F, Rose IVL, Herrington KA, Bax S et al. mTOR controls neurotoxic lysosome exocytosis in inflammatory reactive astrocytes. 2021;1–32.

Lo CH, Zeng J, Loi GWZ, Saipuljumri EN, O’Connor LM, Indajang J et al. Defective lysosomal acidification contributes to TNFR1 mediated neuronal necroptosis in Alzheimer’s disease. bioRxiv. 2023;2023.10.12.562041.

Leng K, Rooney B, McCarthy F, Xia W, Rose IVL, Bax S, et al. mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes. J Neuroinflamm. 2024;21:198.

Article  CAS  Google Scholar 

Jung B-K, Park Y, Yoon B, Bae J-S, Han S-W, Heo J-E, et al. Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage. Autophagy. 2023;19:2296–317.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee E, Jung Y-J, Park YR, Lim S, Choi Y-J, Lee SY, et al. A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis. Nat Aging. 2022;2:726–41.

Article  CAS  PubMed  Google Scholar 

Simmnacher K, Krach F, Schneider Y, Alecu JE, Mautner L, Klein P, et al. Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020;334:113466.

Article  CAS  PubMed  Google Scholar 

Beckel JM, Gómez NM, Lu W, Campagno KE, Nabet B, Albalawi F et al. Stimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels. Sci Rep. 2018;8.

Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, et al. Gut-licensed IFNγ + NK cells drive LAMP1 + TRAIL + anti-inflammatory astrocytes. Nature. 2021;590:473–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Malta C, Fryer JD, Settembre C, Ballabio A. Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder. Proc Natl Acad Sci USA. 2012;109:E2334–42.

Article  PubMed  PubMed Central  Google Scholar 

Aflaki E, Stubblefield BK, McGlinchey RP, McMahon B, Ory DS, Sidransky E. A characterization of gaucher iPS-derived astrocytes: potential implications for Parkinson’s disease. Neurobiol Dis. 2020;134:104647.

Article