Assessment of Electroacupuncture Therapy with Distant-Approximal Acupoints Based on the HPT Axis in Rats with Oligoasthenospermia Through Transcriptomic Analysis

Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, Rienzi L, Sunde A, Schmidt L, Cooke ID, Simpson JL, van der Poel S. The international glossary on infertility and fertility care, 2017. Human Reprod (Oxford, England). 2017;32:1786–801.

Article  Google Scholar 

Agarwal A, Baskaran S, Parekh N, Cho C-L, Henkel R, Vij S, Arafa M, Panner Selvam MK, Shah R. Male infertility. Lancet. 2021;397:319–33.

Article  PubMed  Google Scholar 

Concepción-Zavaleta M, Paz Ibarra JL, Ramos-Yataco A, Coronado-Arroyo J, Concepción-Urteaga L, Roseboom PJ, Williams CA. Assessment of hormonal status in male infertility. An update. Diabetes Metab Syndr: Clin Res Rev. 2022;16:102447.

Article  Google Scholar 

Björndahl L, Kirkman Brown J. The sixth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen: ensuring quality and standardization in basic examination of human ejaculates. Fertility and Sterility. 2022;117:246–51.

Article  PubMed  Google Scholar 

Miller D, Vukina J. Recent advances in clinical diagnosis and treatment of male factor infertility. Postgrad Med. 2020;132:28–34.

Article  PubMed  Google Scholar 

Jiang Z, Zhou B, Li X, Kirby GM, Zhang X. Echinacoside increases sperm quantity in rats by targeting the hypothalamic androgen receptor. Sci Rep. 2018;8(1):3839.

Choy JT, Amory JK. Nonsurgical management of oligozoospermia. J Clin Endocrinol Metab. 2020;105:e4194–207.

Article  PubMed  PubMed Central  Google Scholar 

Duca Y, Calogero AE, Cannarella R, Condorelli RA, La Vignera S. Current and emerging medical therapeutic agents for idiopathic male infertility. Expert Opin Pharmacother. 2018;20:55–67.

Article  PubMed  Google Scholar 

McLachlan RI. Approach to the patient with oligozoospermia. J Clin Endocrinol Metab. 2013;98:873–80.

Article  CAS  PubMed  Google Scholar 

Colpi GM, Francavilla S, Haidl G, Link K, Behre HM, Goulis DG, Krausz C, Giwercman A. European academy of andrology guideline management of oligo-astheno-teratozoospermia. Andrology. 2018;6:513–24.

Article  CAS  PubMed  Google Scholar 

Wang Z, Zhou Z, Zhang L, Li X, Li M, Pan Y, Jiao T, Shi X, Liu Q, Wang C, Wang Y. Efficacy and safety of nonpharmacological strategies for the treatment of oligoasthenospermia: a systematic review and Bayesian network meta-analysis. Eur J Med Res. 2023;28(1):6.

Wu X, Chen D, Zhou Y, Xia T. Efficacy of electroacupuncture for the treatment of asthenozoospermia: A protocol for systematic review and meta-analysis. Medicine. 2021;100:e23350.

Article  PubMed  PubMed Central  Google Scholar 

Nurwati I, Murti B, Budihastuti UR, Prakosa T, Laqif A, Melinawati E, Prasetya H, Susanto L, Sukmawati M. Electroacupuncture effectiveness for treating idiopathic male infertility. Med Acupunct. 2022;34:405–9.

Article  PubMed  PubMed Central  Google Scholar 

Zhang X, Zhang P, Song D, Xiong S, Zhang H, Fu J, Gao F, Chen H, Zeng X. Expression profiles and characteristics of human lncRNA in normal and asthenozoospermia sperm†. Biol Reprod. 2019;100:982–93.

Article  PubMed  Google Scholar 

Jodar M, Kalko S, Castillo J, Ballescà JL, Oliva R. Differential RNAs in the sperm cells of asthenozoospermic patients. Hum Reprod. 2012;27:1431–8.

Article  CAS  PubMed  Google Scholar 

Yang N, Wei X-G, Li K, Wang F, Song F, Sun W, Wang Y, Zhao Z, Mu J, Ma H. Transcriptomic analysis of the HPT axis in a model of oligoasthenozoospermia induced by Adenine in rats. Exp Mol Pathol. 2024;141:104948.

Article  PubMed  Google Scholar 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498–504.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Lan C-N, Kong Y, Feng S-S, Huang T. Identification and analysis of blood gene expression signature for osteoarthritis with advanced feature selection methods. Front Genetics. 2018;9:246.

Kumar A, Raut S, Balasinor NH. Endocrine regulation of sperm release. Reprod Fertil Dev. 2018;30:1595.

Article  CAS  PubMed  Google Scholar 

Huang N-W, Li H-S, Wang B, Wang J-S, Feng J-L, Sun L-J, Dang J. Discussion on the pathogenesis of oligoasthenozoospermia based on the theory of kidney dominating reproduction and the formulation of Guilu Yulin Decoction. Journal of Tianjin University of Traditional Chinese Medicine. 2024;43:285-88. (in Chinese)

Li W, Ye B-S, Huang Z, Feng J, Chen Q, Huang H, Zhou H, Liu Y-S, Qie F-Q, Shi X-L. Research progress on postmenopausal osteoporosis from the perspective of depletion of the heavenly water and blocked earthly channels. Chinese Journal of Integrated Traditional and Western Medicine. 2024;44:623–26. (in Chinese)

Zhu S, Gao Y, Chen S, Liu L, Feng L, Qiu L. The effect of Yihechun oral liquid on the testicular function of rats with kidney-yang deficiency. Tradis Chin Drug Res Clin Pharmacol. 2010;21:133–6. (in Chinese)

Google Scholar 

Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K. Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int. 2014;2014:1–19.

Article  Google Scholar 

Ihsan AU, Khan FU, Khongorzul P, Ahmad KA, Naveed M, Yasmeen S, Cao Y, Taleb A, Maiti R, Akhter F, Liao X, Li X, Cheng Y, Khan HU, Alam K, Zhou X. Role of oxidative stress in pathology of chronic prostatitis/chronic pelvic pain syndrome and male infertility and antioxidants function in ameliorating oxidative stress. Biomed Pharmacother. 2018;106:714–23.

Article  CAS  PubMed  Google Scholar 

Ding J, Lu B, Liu L, Zhong Z, Wang N, Li B, Sheng W, He Q. Guilu-erxian-glue alleviates tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway. Pharm Biol. 2023;61:213–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ribeiro JC, Nogueira-Ferreira R, Amado F, Alves MG, Ferreira R, Oliveira PF. Exploring the role of oxidative stress in sperm motility: A proteomic network approach. Antioxid Redox Signal. 2022;37:501–20.

Article  CAS  PubMed  Google Scholar 

Wei Y, Cao X-N, Tang X-L, Shen L-J, Lin T, He D-W, Wu S-D, Wei G-H. Urban fine particulate matter (PM2.5) exposure destroys blood–testis barrier (BTB) integrity through excessive ROS-mediated autophagy. Toxicol Mech Methods. 2017;28:302–19.

Article  PubMed  Google Scholar 

Zhao G, Wang Y, Lai Z, Zheng L, Zhao D. Echinacoside protects against dysfunction of spermatogenesis through the MAPK signaling pathway. Reprod Sci. 2021;29:1586–96.

Article  PubMed  Google Scholar 

Schneider M, Förster H, Boersma A, Seiler A, Wehnes H, Sinowatz F, Neumüller C, Deutsch MJ, Walch A, Hrabé de Angelis M, Wurst W, Ursini F, Roveri A, Maleszewski M, Maiorino M, Conrad M. Mitochondrial glutathione peroxidase 4 disruption causes male infertility. FASEB J : Off Pub Fed Am Soc Exp Biol. 2009;23:3233–42.

Article  CAS  Google Scholar 

Chabory E, Damon C, Lenoir A, Kauselmann G, Kern H, Zevnik B, Garrel C, Saez F, Cadet R, Henry-Berger J, Schoor M, Gottwald U, Habenicht U, Drevet JR, Vernet P. Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. J Clin Investig. 2009;119:2074–85.

CAS  PubMed  PubMed Central  Google Scholar 

Haidari F, Mohammadi-Asl J, Kavianpour M, Dadfar M, Haghighian HK. Effect of lipoic acid supplementation on gene expression and activity of glutathione S-transferase enzyme in infertile men. Hum Fertil. 2019;24:276–83.

Article  Google Scholar 

He J, Mu Y, Liu M, Che B-W, Zhang W-J, Chen K-H, Tang K-F. Glutathione S-transferase genetic polymorphisms and fluoride-induced reproductive toxicity in men with idiopathic infertility. Asian J Androl. 2023;25:404–9.

Article  CAS  PubMed  Google Scholar 

Rezatabar S, Karimian A, Rameshknia V, Parsian H, Majidinia M, Kopi TA, Bishayee A, Sadeghinia A, Yousefi M, Monirialamdari M, Yousefi B. RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression. J Cell Physiol. 2019;234:14951–65.

Article  CAS  PubMed  Google Scholar 

Kim EK, Choi E-J. Pathological roles of MAPK signaling pathways in human diseases. Biochimica et Biophysica Acta (BBA) - Mol Basis Dis. 2010;1802:396–405.

Article  CAS  Google Scholar 

Almog T, Naor Z. The role of mitogen activated protein kinase (MAPK) in sperm functions. Mol Cell Endocrinol. 2010;314:239–43.

Article  CAS  PubMed  Google Scholar 

Yu L, Yang X, Ma B, Ying H, Shang X, He B, Zhang Q. Abnormal arachidonic acid metabolic network may reduce sperm motility via P38 MAPK. Open Biol. 2019;9:180091.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takata T, Araki S, Tsuchiya Y, Watanabe Y. Oxidative stress orchestrates MAPK and nitric-oxide synthase signal. Int J Mol Sci. 2020;21(22):8750.

Article 

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