Effects of Selective Serotonin Reuptake Inhibitors and Ondansetron on Urinary Tract Infections in Pregnancy

Yan L, et al. The association between urinary tract infection during pregnancy and preeclampsia: A meta-analysis. Medicine (Baltimore). 2018;97(36):e12192.

Article  PubMed  Google Scholar 

Romero R, et al. Meta-analysis of the relationship between asymptomatic bacteriuria and preterm delivery/low birth weight. Obstet Gynecol. 1989;73(4):576–82.

CAS  PubMed  Google Scholar 

Kessous R, et al. Bacteruria with group-B streptococcus: is it a risk factor for adverse pregnancy outcomes? J Matern Fetal Neonatal Med. 2012;25(10):1983–6.

Article  PubMed  Google Scholar 

Hantush Zadeh S, et al. Idiopathic urinary findings and fetal growth restriction in low risk pregnancy. Eur J Obstet Gynecol Reprod Biol. 2013;171(1):57–60.

Article  PubMed  Google Scholar 

Kalinderi K, et al. Urinary tract infection during pregnancy: current concepts on a common multifaceted problem. J Obstet Gynaecol. 2018;38(4):448–53.

Article  PubMed  Google Scholar 

Ghouri F, Hollywood A, Ryan K. Urinary tract infections and antibiotic use in pregnancy - qualitative analysis of online forum content. BMC Pregnancy Childbirth. 2019;19(1):289.

Article  PubMed  PubMed Central  Google Scholar 

Ambrogi M, et al. A 5-HT-mediated urethral defense against urinary tract infections. PNAS. 2024. Under review.

Rogowski A, et al. Psychiatric history and overactive bladder symptom severity in ambulatory urogynecological patients. J Clin Med. 2021;10(17):3988.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye JH, Ponnudurai R, Schaefer R. Ondansetron: A selective 5-HT3 receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 2001;7(2):199–213.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh NN, et al. Ondansetron and seizures. Epilepsia. 2009;50(12):2663–6.

Article  CAS  PubMed  Google Scholar 

Lee NM, Saha S. Nausea and vomiting of pregnancy. Gastroenterol Clin North Am. 2011;40(2):309–34.

Article  PubMed  PubMed Central  Google Scholar 

Siminerio LL, et al. Ondansetron use in pregnancy. Obstet Gynecol. 2016;127(5):873–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gavin NI, et al. Perinatal depression: A systematic review of prevalence and incidence. Obstet Gynecol. 2005;106(5 Pt 1):1071–83.

Article  PubMed  Google Scholar 

Fung TC, et al. Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut. Nat Microbiol. 2019;4(12):2064–73.

Article  PubMed  PubMed Central  Google Scholar 

Desorcy-Scherer K, Fricke HP, Hernandez LL. Selective serotonin reuptake inhibitors during pregnancy and lactation: A scoping review of effects on the maternal and infant gut microbiome. Dev Psychobiol. 2024;66(1):e22441.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhattarai Y, Muniz Pedrogo DA, Kashyap PC. Irritable bowel syndrome: a gut microbiota-related disorder? Am J Physiol Gastrointest Liver Physiol. 2017;312(1):G52–62.

Article  PubMed  Google Scholar 

Naji A, et al. The role of the gut, urine, and vaginal microbiomes in the pathogenesis of urinary tract infection in women and consideration of microbiome therapeutics. Open Forum Infect Dis. 2024;11(9):ofae471.

Article  PubMed  PubMed Central  Google Scholar 

Antony KM, et al. Generation and validation of a universal perinatal database and biospecimen repository: PeriBank. J Perinatol. 2016;36(11):921–9.

Article  CAS  PubMed  Google Scholar 

Burd JE, et al. Blood type and postpartum hemorrhage by mode of delivery: A retrospective cohort study. Eur J Obstet Gynecol Reprod Biol. 2021;256:348–53.

Article  PubMed  Google Scholar 

Mysorekar IU, Hultgren SJ. Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract. Proc Natl Acad Sci. 2006;103(38):14170–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langermann S, et al. Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli. J Infect Dis. 2000;181(2):774–8.

Article  CAS  PubMed  Google Scholar 

Valdivia RH, et al. Applications for green fluorescent protein (GFP) in the study of host-pathogen interactions. Gene. 1996;173(1spec No):47–52.

Article  CAS  PubMed  Google Scholar 

Thai KH, Thathireddy A, Hsieh MH. Transurethral induction of mouse urinary tract infection. J Vis Exp. 2010;(42):2070. https://doi.org/10.3791/2070-v

Georgiou PC, et al. Bacterial quantification in tissue homogenates from in vivo pharmacodynamic studies using growth curves. J Med Microbiol. 2020;69(5):676–84.

Article  CAS  PubMed  Google Scholar 

Minami M, et al. Chemical modulation of 5-HT3 and 5-HT4 receptors affects the release of 5-hydroxytryptamine from the ferret and rat intestine. Res Commun Mol Pathol Pharmacol. 1995;89(2):131–42.

CAS  PubMed  Google Scholar 

Du Bois A, et al. 5-Hydroxyindoleacetic acid excretion following combination chemotherapy with cyclophosphamide, epirubicin and 5-fluorouracil plus ondansetron compared to ondansetron alone. Support Care Cancer. 1996;4(5):384–9.

Article  PubMed  Google Scholar 

Chenu F, El Mansari M, Blier P. Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area. Int J Neuropsychopharmacol. 2009;12(4):475–85.

Article  CAS  PubMed  Google Scholar 

Schwartz MA, et al. Risk factors for urinary tract infection in the postpartum period. Am J Obstet Gynecol. 1999;181(3):547–53.

Article  CAS  PubMed  Google Scholar 

Naber KG, et al. Psychosocial burden of recurrent uncomplicated urinary tract infections. GMS Infect Dis. 2022;10:Doc01.

PubMed  PubMed Central  Google Scholar 

Upadhyaya S, et al. Maternal SSRI use during pregnancy and offspring depression or anxiety disorders: A review of the literature and description of a study protocol for a register-based cohort study. Reprod Toxicol. 2023;118:108365.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rami M, et al. Chronic intake of the selective serotonin reuptake inhibitor fluoxetine enhances atherosclerosis. Arterioscler Thromb Vasc Biol. 2018;38(5):1007–19.

Article  CAS  PubMed  Google Scholar 

Gobin V, et al. Selective serotonin reuptake inhibitors as a novel class of immunosuppressants. Int Immunopharmacol. 2014;20(1):148–56.

Article  CAS  PubMed  Google Scholar 

Liu H-N, et al. Serotonin augments gut pacemaker activity via 5-HT3 receptors. PLoS ONE. 2011;6(9):e24928.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Motavallian-Naeini A, et al. Anti-inflammatory effect of ondansetron through 5-HT3 receptors on TNBS-induced colitis in rat. EXCLI J. 2012;11:30–44.

PubMed  PubMed Central  Google Scholar 

Taghavi Zahedkalaei A, et al. Association between urinary tract infection in the first trimester and risk of preeclampsia: A case-control study. Int J Wome

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