Gomes ACM et al (2022) Escorpiões do gênero Tityus no Brasil: biologia, bioquímica da peçonha e fisiopatologia do escorpionismo. Scientia Vitae 13:1–14
Parrela AFB et al (2022) Scorpion envenomation in Brazil: an update. Infectio 26:172–18. https://doi.org/10.22354/in.v26i2.1018
Carvalho LS et al (2017) Checklist dos escorpiões (Arachnida, Scorpiones) do Mato Grosso do Sul. Brasil Iheringia Série Zoologia 107:1–7. https://doi.org/10.1590/1678-4766e2017108
Brazil TK, Porto TJ (2010) Os Escorpiões. EDUFBA, Salvador
Santussi WM et al (2017) Antifungal activity against filamentous fungi of Ts1, a multifunctional toxin from Tityus serrulatus scorpion venom. Front Microbiol 8:1–15. https://doi.org/10.3389/fmicb.2017.00984
Bernardes-Oliveira E et al (2019) Tityus serrulatus scorpion venom induces apoptosis in cervical cancer cell lines. Evid Based Complement Alternat Med 2019:1–8. https://doi.org/10.1155/2019/5131042
Martin-Eauclaire MF, Bougis PE, Lima ME (2018) Ts1 from the Brazilian scorpion Tityus serrulatus: A half-century of studies on a multifunctional beta like-toxin. Toxicon 152:106–120. https://doi.org/10.1016/j.toxicon.2018.07.024
Article CAS PubMed Google Scholar
Pucca MB et al (2015) Tityus serrulatus venom – A lethal cocktail. Toxicon 108:272–284. https://doi.org/10.1016/j.toxicon.2015.10.015
Article CAS PubMed Google Scholar
Fialho EMS et al (2011) Immune cells recruitment and activation by Tityus serrulatus scorpion venom. Toxicon 58:480–485. https://doi.org/10.1016/j.toxicon.2011.08.006
Article CAS PubMed Google Scholar
Vasconcelos F et al (2005) Effects of voltage-gated Na+ channel toxins from Tityus serrulatus venom on rat arterial blood pressure and plasma catecholamines. Comp Biochem Physiol C Toxicol Pharmacol 141:85–92. https://doi.org/10.1016/j.cca.2005.05.012
Article CAS PubMed Google Scholar
Sawynok J et al (1997) Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine. Eur J Pharmacol 333:1–7. https://doi.org/10.1016/s0014-2999(97)01110-2
Article CAS PubMed Google Scholar
Sawynok J, Reid A, Liu XJ (2000) Involvement of mast cells, sensory afferents and sympathetic mechanisms in paw edema induced by adenosine A(1) and A(2B/3) receptor agonists. Eur J Pharmacol 395:47–50. https://doi.org/10.1016/s0014-2999(00)00125-4
Article CAS PubMed Google Scholar
Abroug F et al (2020) Scorpion envenomation: state of the art. Intensive Care Med 46:401–410. https://doi.org/10.1007/s00134-020-05924-8
Article CAS PubMed Google Scholar
Aird SD (2002) Ophidian envenomation strategies and the role of purines. Toxicon 40:335–393. https://doi.org/10.1016/s0041-0101(01)00232-x
Article CAS PubMed Google Scholar
Sales PBV, Santoro ML (2008) Nucleotidase and DNase activities in Brazilian snake venoms. Comp Biochem Physiol C toxicol Pharmacol 147:85–95. https://doi.org/10.1016/j.cbpc.2007.08.003
Article CAS PubMed Google Scholar
Burnstock G (2007) Purine and pyrimidine receptors. Cell Mol Life Sci 64:1471–1483. https://doi.org/10.1007/s00018-007-6497-0
Article CAS PubMed PubMed Central Google Scholar
Atkinson B et al (2006) Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets. Blood Cells Mol Dis 36:217–222. https://doi.org/10.1016/j.bcmd.2005.12.025
Article CAS PubMed Google Scholar
Yang D et al (2010) A new role for the A2b adenosine receptor in regulating platelet function. J Thromb Haemost 8:817–827. https://doi.org/10.1111/j.1538-7836.2010.03769.x
Article CAS PubMed Google Scholar
Linden J, Koch-Nolte F, Dahl G (2019) Purine release, metabolism, and signaling in the inflammatory response. Annu Rev Immunol 37:325–347. https://doi.org/10.1146/annurev-immunol-051116-052406
Article CAS PubMed Google Scholar
Bono MR et al (2015) CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression. FEBS lett 589:3454–3460. https://doi.org/10.1016/j.febslet.2015.07.027
Article CAS PubMed Google Scholar
Saze Z et al (2013) Adenosine production by human B cells and B cell-mediated suppression of activated T cells. Blood 122:9–18. https://doi.org/10.1182/blood-2013-02-482406
Article CAS PubMed PubMed Central Google Scholar
Cekic C, Linden J (2016) Purinergic regulation of the immune system. Nat Rev Immunol 16:177–192. https://doi.org/10.1038/nri.2016.4
Article CAS PubMed Google Scholar
Di Virgilio F, Vuerich M (2015) Purinergic signaling in the immune system. Auton Neurosci 191:117–123. https://doi.org/10.1016/j.autneu.2015.04.011
Article CAS PubMed Google Scholar
Di Virgilio F et al (2001) Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 97:587–600. https://doi.org/10.1182/blood.v97.3.587
Di Virgilio F et al (2018) Extracellular ATP and P2 purinergic signalling in the tumour microenvironment. Nat Rev Cancer 18:601–6018. https://doi.org/10.1038/s41568-018-0037-0
Article CAS PubMed Google Scholar
Cardoso AM, Manfredi LH, Maciel SFVO (2021) Sinalização purinérgica: implicações fisiopatológicas. Editora UFFS, Brasil
Yegutkin GG (2014) Enzymes involved in metabolism of extracellular nucleotides and nucleosides: Functional implications and measurement of activities. Crit Rev Biochem Mol Biol 49:473–497. https://doi.org/10.3109/10409238.2014.953627
Article CAS PubMed Google Scholar
Burnstock G, Vaughn B, Robson SC (2014) Purinergic signalling in the liver in health and disease. Purinergic Signal 10:51–70. https://doi.org/10.1007/s11302-013-9398-8
Article CAS PubMed Google Scholar
Zimmermann H (2021) History of ectonucleotidases and their role in purinergic signaling. Biochem Pharmacol 187:1–77. https://doi.org/10.1016/j.bcp.2020.114322
Sheth S et al (2014) Adenosine receptors: expression, function and regulation. Int J Mol Sci 15:2024–2052. https://doi.org/10.3390/ijms15022024
Article CAS PubMed PubMed Central Google Scholar
Burnstock G (2006). Purinergic signalling - An overview. Novartis Found Symp 26–53. https://doi.org/10.1002/9780470032244.ch4
Junger WG (2011) Immune cell regulation by autocrine purinergic signalling. Nat Rev Immunol 11:201–212. https://doi.org/10.1038/nri2938
Article CAS PubMed PubMed Central Google Scholar
Huang Z et al (2021) From purines to purinergic signalling: molecular functions and human diseases. Signal Transduct Target Ther 6:162–182.
Comments (0)