Yamamoto T, Hasegawa T, Fraitas PHL, Hongo H, Zhao S, Yamamoto T, Nasoori A, Abe M, Maruoka H, Kubota K, Morimoto Y, Haraguchi M, Shimizu T, Takahata M, Iwasaki N, Li M, Amizuka N (2021) Histochemical characteristics on minimodeling-based bone formation induced by anabolic drugs for osteoporotic treatment. Biomed Res 42:161–171

Article  CAS  PubMed  Google Scholar 

Jee WS, Tian XY, Setterberg RB (2007) Cancellous bone minimodeling-based formation: a Frost, Takahashi legacy. J Musculoskelet Neuronal Interact 7:232–239

CAS  PubMed  Google Scholar 

Yamamoto T, Hasegawa T, Sasaki M, Hongo H, Tsuboi K, Shimizu T, Ota M, Haraguchi M, Takahata M, Oda K, Luiz de Freitas PH, Takakura A, Takao-Kawabata R, Isogai Y, Amizuka N (2016) Frequency of teriparatide administration affects the histological pattern of bone formation in young adult male mice. Endocrinology 157:2604–2620

Article  CAS  PubMed  Google Scholar 

Hasegawa T, Yamamoto T, Sakai S, Miyamoto Y, Hongo H, Qiu Z, Abe M, Takeda S, Oda K, de Freitas PHL, Li M, Endo K, Amizuka N (2019) Histological effects of the combined administration of eldecalcitol and a parathyroid hormone in the metaphyseal trabeculae of ovariectomized rats. J Histochem Cytochem 67:169–184

Article  CAS  PubMed  Google Scholar 

Orwoll E, Scheele W, Paul S, Adami S, Syversen U, Diez-Perez A, Kaufman JM, Clancy AD, Gaich GA (2003) The effect of teriparatide [human parathyroid hormone (1–34)] therapy on bone density in men with osteoporosis. J Bone Miner Res 18:9–17

Article  CAS  PubMed  Google Scholar 

Schweser KM, Crist BD (2017) Osteoporosis: a discussion on the past 5 years. Curr Rev Musculoskelet Med 10:265–274

Article  PubMed  PubMed Central  Google Scholar 

Luiz de Freitas PH, Li M, Ninomiya T, Nakamura M, Ubaidus S, Oda K, Udagawa N, Maeda T, Takagi R, Amizuka N (2009) Intermittent PTH administration stimulates pre-osteoblastic proliferation without leading to enhanced bone formation in osteoclast-less c-fos(-/-) mice. J Bone Miner Res 24:1586–1597

Article  CAS  PubMed  Google Scholar 

Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O’Keefe RJ, Schwarz EM (2013) PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis. J Bone Miner Res 28:586–597

Article  CAS  PubMed  Google Scholar 

Jiang X, Xu C, Shi H, Cheng Q (2019) PTH 1–34 improves bone healing by promoting angiogenesis and facilitating MSCs migration and differentiation in a stabilized fracture mouse model. PLoS ONE 14:e0226163

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao S, Hasegawa T, Hongo H, Yamamoto T, Abe M, Yoshida T, Haraguchi M, Freitas PHL, Li M, Tei K, Amizuka N (2021) Intermittent PTH administration increases bone-specific blood vessels and surrounding stromal cells in murine long bones. Calcif Tissue Int 108:391–406

Article  CAS  PubMed  Google Scholar 

Lotinun S, Evans GL, Bronk JT, Bolander ME, Wronski TJ, Ritman EL, Turner RT (2004) Continuous parathyroid hormone induces cortical porosity in the rat: effects on bone turnover and mechanical properties. J Bone Miner Res 19:1165–1171

Article  CAS  PubMed  Google Scholar 

Leder BZ, O’Dea LS, Zanchetta JR, Kumar P, Banks K, McKay K, Lyttle CR, Hattersley G (2015) Effects of abaloparatide, a human parathyroid hormone-related peptide analog, on bone mineral density in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 100:697–706

Article  CAS  PubMed  Google Scholar 

Miller PD, Hattersley G, Riis BJ, Williams GC, Lau E, Russo LA, Alexandersen P, Zerbini CA, Hu MY, Harris AG, Fitzpatrick LA, Cosman F, Christiansen C, ACTIVE tudy Investigators (2016) Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: a randomized clinical trial. JAMA 316:722–733

Article  CAS  PubMed  Google Scholar 

Hattersley G, Dean T, Corbin BA, Bahar H, Gardella TJ (2016) Binding selectivity of abaloparatide for PTH-type-1-receptor conformations and effects on downstream signaling. Endocrinology 157:141–149

Article  CAS  PubMed  Google Scholar 

Varela A, Chouinard L, Lesage E, Guldberg R, Smith SY, Kostenuik PJ, Hattersley G (2017) One year of abaloparatide, a selective peptide activator of the PTH1 receptor, increased bone mass and strength in ovariectomized rats. Bone 95:143–150

Article  CAS  PubMed  Google Scholar 

Varela A, Chouinard L, Lesage E, Smith SY, Hattersley G (2017) One year of abaloparatide, a selective activator of the PTH1 receptor, increased bone formation and bone mass in osteopenic ovariectomized rats without increasing bone resorption. J Bone Miner Res 32:24–33

Article  CAS  PubMed  Google Scholar 

Doyle N, Varela A, Haile S, Guldberg R, Kostenuik PJ, Ominsky MS, Smith SY, Hattersley G (2018) Abaloparatide, a novel PTH receptor agonist, increased bone mass and strength in ovariectomized cynomolgus monkeys by increasing bone formation without increasing bone resorption. Osteoporos Int 29:685–697

Article  CAS  PubMed  Google Scholar 

Chandler H, Lanske B, Varela A, Guillot M, Boyer M, Brown J, Pierce A, Ominsky M, Mitlak B, Baron R, Kostenuik P, Hattersley G (2019) Abaloparatide, a novel osteoanabolic PTHrP analog, increases cortical and trabecular bone mass and architecture in orchiectomized rats by increasing bone formation without increasing bone resorption. Bone 120:148–155

Article  CAS  PubMed  Google Scholar 

Makino A, Hasegawa T, Takagi H, Takahashi Y, Hase N, Amizuka N (2021) Frequent administration of abaloparatide shows greater gains in bone anabolic window and bone mineral density in mice: a comparison with teriparatide. Bone 142:115651

Article  CAS  PubMed  Google Scholar 

Lindsay R, Nieves J, Formica C, Henneman E, Woelfert L, Shen V, Dempster D, Cosman F (1997) Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis. Lancet 350:550–555

Article  CAS  PubMed  Google Scholar 

Yamamoto T, Maruoka H, Hongo H, Yoshino H, Haraguchi-Kitakamae M, Liu X, Yao Q, Li M, Amizuka N, Hasegawa T (2023) Early gene expression profiles of anabolic and catabolic molecules in murine bone after a single PTH injection. J Oral Biosci 65:395–400

Article  CAS  PubMed  Google Scholar 

Haraguchi-Kitakamae M, Nakajima Y, Yamamoto T, Hongo H, Cui J, Shi Y, Liu X, Yao Q, Maruoka H, Abe M, Sekiguchi T, Yokoyama A, Amizuka N, Sasano Y, Hasegawa T (2024) Regional difference in the distribution of alkaline phosphatase, PHOSPHO1, and calcein labeling in the femoral metaphyseal trabeculae in parathyroid hormone-administered mice. J Oral Biosci S1349–0079:00144

Google Scholar 

Kusumbe AP, Ramasamy SK, Adams RH (2014) Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature 507:323–328

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramasamy SK, Kusumbe AP, Wang L, Adams RH (2014) Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature 507:376–380

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsuchiya E, Hasegawa T, Hongo H, Yamamoto T, Abe M, Yoshida T, Zhao S, Tsuboi K, Udagawa N, Luiz H, de Freitas P, Li M, Kitagawa Y, Amizuka N (2021) Histochemical assessment on the cellular interplay of vascular endothelial cells and septoclasts during endochondral ossification in mice. Microscopy (Oxf) 70:201–214

Article  CAS  PubMed  Google Scholar 

Maruoka H, Yamamoto T, Zhao S, Hongo H, Abe M, Ishizu H, Yoshino H, Luiz de Freitas PH, Li M, Hasegawa T (2022) Histological functions of parathyroid hormone on bone formation and bone blood vessels. J Oral Biosci 64:279–286

Article  CAS  PubMed  Google Scholar 

Maruoka H, Zhao S, Yoshino H, Abe M, Yamamoto T, Hongo H, Haraguchi-Kitakamae M, Nasoori A, Ishizu H, Nakajima Y, Omaki M, Shimizu T, Iwasaki N, Luiz de Freitas PH, Li M, Hasegawa T (2022) Histochemical examination of blood vessels in murine femora with intermittent PTH administration. J Oral Biosci 64:329–336

Article  CAS  PubMed  Google Scholar 

Cohn Yakubovich D, Eliav U, Yalon E, Schary Y, Sheyn D, Cook-Wiens G, Sun S, McKenna CE, Lev S, Binshtok AM, Pelled G, Navon G, Gazit D, Gazit ZC (2017) Teriparatide attenuates scarring around murine cranial bone allograft via modulation of angiogenesis. Bone 97:192–200

Article  CAS  PubMed  Goog