Spatial multiomic landscape of the human placenta at molecular resolution

Maltepe, E. & Fisher, S. J. Placenta: the forgotten organ. Annu. Rev. Cell Dev. Biol. 31, 523–552 (2015).

Article  CAS  PubMed  Google Scholar 

Lee, E. D. & Mistry, H. D. Placental related disorders of pregnancy 2.0. Int. J. Mol. Sci. 24, 14286 (2023).

Article  PubMed  Google Scholar 

Burton, G. J. & Fowden, A. L. The placenta: a multifaceted, transient organ. Philos. Trans. R. Soc. Lond. B Biol. Sci. 370, 20140066 (2015).

Article  PubMed  Google Scholar 

Costanzo, V., Bardelli, A., Siena, S. & Abrignani, S. Exploring the links between cancer and placenta development. Open Biol. 8, 180081 (2018).

Article  PubMed  Google Scholar 

Vento-Tormo, R. et al. Single-cell reconstruction of the early maternal–fetal interface in humans. Nature 563, 347–353 (2018).

Article  CAS  PubMed  Google Scholar 

Greenbaum, S. et al. A spatially resolved timeline of the human maternal–fetal interface. Nature 619, 595–605 (2023).

Article  CAS  PubMed  Google Scholar 

Arutyunyan, A. et al. Spatial multiomics map of trophoblast development in early pregnancy. Nature 616, 143–151 (2023).

Article  CAS  PubMed  Google Scholar 

Russell, A. J. C. et al. Slide-tags enables single-nucleus barcoding for multimodal spatial genomics. Nature 625, 101–109 (2024).

Article  CAS  PubMed  Google Scholar 

Wang, X. et al. Three-dimensional intact-tissue sequencing of single-cell transcriptional states. Science 361, eaat5691 (2018).

Article  PubMed  Google Scholar 

Haider, S. et al. Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta. Proc. Natl Acad. Sci. USA 119, e2120667119 (2022).

Article  CAS  PubMed  Google Scholar 

Upadhyay, G. Emerging role of lymphocyte antigen-6 family of genes in cancer and immune cells. Front. Immunol. 10, 819 (2019).

Article  CAS  PubMed  Google Scholar 

Sebastian, A. et al. Single-cell transcriptomic analysis of tumor-derived fibroblasts and normal tissue-resident fibroblasts reveals fibroblast heterogeneity in breast cancer. Cancers 12, 1307 (2020).

Article  CAS  PubMed  Google Scholar 

Lake, D. F. & Faigel, D. O. The emerging role of QSOX1 in cancer. Antioxid. Redox Signal. 21, 485–496 (2014).

Article  CAS  PubMed  Google Scholar 

Lu, M. et al. FGFR1 promotes tumor immune evasion via YAP-mediated PD-L1 expression upregulation in lung squamous cell carcinoma. Cell. Immunol. 379, 104577 (2022).

Article  CAS  PubMed  Google Scholar 

Zhang, P. et al. Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors. Nat. Commun. 13, 1588 (2022).

Article  CAS  PubMed  Google Scholar 

Gabut, M. et al. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell 147, 132–146 (2011).

Article  CAS  PubMed  Google Scholar 

Vasilopoulou, E. et al. Triiodothyronine regulates angiogenic growth factor and cytokine secretion by isolated human decidual cells in a cell-type specific and gestational age-dependent manner. Hum. Reprod. 29, 1161–1172 (2014).

Article  CAS  PubMed  Google Scholar 

Purvis, G. S. D., Solito, E. & Thiemermann, C. Annexin-A1: therapeutic potential in microvascular disease. Front. Immunol. 10, 938 (2019).

Article  CAS  PubMed  Google Scholar 

Neuper, L. et al. Candesartan does not activate PPARγ and its target genes in early gestation trophoblasts. Int. J. Mol. Sci. 23, 12326 (2022).

Article  CAS  PubMed  Google Scholar 

Radford, B. N. et al. Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease. Nat. Commun. 14, 1174 (2023).

Article  CAS  PubMed  Google Scholar 

Rooda, I. et al. Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells. Sci. Rep. 10, 2300 (2020).

Article  CAS  PubMed  Google Scholar 

Hu, L.-T., Wang, B.-Y., Fan, Y.-H., He, Z.-Y. & Zheng, W.-X. Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage. Neural Regen. Res. 18, 560–567 (2023).

Article  CAS  PubMed  Google Scholar 

Renaud, S. J., Kubota, K., Rumi, M. A. K. & Soares, M. J. The FOS transcription factor family differentially controls trophoblast migration and invasion. J. Biol. Chem. 289, 5025–5039 (2014).

Article  CAS  PubMed  Google Scholar 

Kohli, S. et al. p45 NF-E2 regulates syncytiotrophoblast differentiation by post-translational GCM1 modifications in human intrauterine growth restriction. Cell Death Dis. 8, e2730 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo, H., Wang, Y., Jia, W. & Liu, L. MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway. Physiol. Res. 70, 67–78 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hornbachner, R. et al. MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells. Proc. Natl Acad. Sci. USA 118, e2105130118 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song, H., Wang, X., Li, J.-C. & Lv, Y.-H. MiR-655-3p inhibits growth and invasiveness of trophoblasts via targeting PBX3 and thus deteriorates preeclampsia. Eur. Rev. Med. Pharmacol. Sci. 24, 10346–10351 (2020).

CAS  PubMed  Google Scholar 

Chen, Q. et al. Association of lncRNA SH3PXD2A-AS1 with preeclampsia and its function in invasion and migration of placental trophoblast cells. Cell Death Dis. 11, 583 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song, J. et al. Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/β-catenin pathway in hepatocellular carcinoma. Theranostics 8, 3571–3583 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dietrich, B., Haider, S., Meinhardt, G., Pollheimer, J. & Knöfler, M. WNT and NOTCH signaling in human trophoblast development and differentiation. Cell. Mol. Life Sci. 79, 292 (2022).

Article  CAS  PubMed  Google Scholar 

Varberg, K. M. et al. ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development. Proc. Natl Acad. Sci. USA 118, e2016517118 (2021).

Article  CAS  PubMed  Google Scholar 

Zhou, G. et al. EBF1 Gene mRNA levels in maternal blood and spontaneous preterm birth. Reprod. Sci. 27, 316–324 (2020).

Article  CAS  PubMed 

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