McEwen BS, Bowles NP, Gray JD, Hill MN, Hunter RG, Karatsoreos IN, et al. Mechanisms of stress in the brain. Nat Neurosci. 2015;18:1353–63.
Article CAS PubMed PubMed Central Google Scholar
McEwen BS. Protective and damaging effects of stress mediators. N Engl J Med. 1998;338:171–9.
Article CAS PubMed Google Scholar
Fanselow MS. The role of learning in threat imminence and defensive behaviors. Curr Opin Behav Sci. 2018;24:44–49.
Article PubMed PubMed Central Google Scholar
Romero LM, Gormally BMG. How truly conserved is the “well-conserved” vertebrate stress response? Integr Comp Biol. 2019;59:273–81.
Article CAS PubMed Google Scholar
Blake DD, Cook JD, Keane TM. Post-traumatic stress disorder and coping in veterans who are seeking medical treatment. J Clin Psychol. 1992;48:695–704.
Article CAS PubMed Google Scholar
Lewis SJ, Arseneault L, Caspi A, Fisher HL, Matthews T, Moffitt TE, et al. The epidemiology of trauma and post-traumatic stress disorder in a representative cohort of young people in England and Wales. Lancet Psychiatry. 2019;6:247–56.
Article PubMed PubMed Central Google Scholar
Yuan K, Gong YM, Liu L, Sun YK, Tian SS, Wang YJ, et al. Prevalence of posttraumatic stress disorder after infectious disease pandemics in the twenty-first century, including COVID-19: a meta-analysis and systematic review. Mol Psychiatry. 2021;26:4982–98.
Article CAS PubMed PubMed Central Google Scholar
Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell. 2007;131:391–404.
Article CAS PubMed Google Scholar
Bhatnagar S. Rethinking stress resilience. Trends Neurosci. 2021;44:936–45.
Article CAS PubMed PubMed Central Google Scholar
Nasca C, Menard C, Hodes G, Bigio B, Pena C, Lorsch Z, et al. Multidimensional predictors of susceptibility and resilience to social defeat stress. Biol Psychiatry. 2019;86:483–91.
Article CAS PubMed PubMed Central Google Scholar
Zhang TR, Larosa A, Di Raddo ME, Wong V, Wong AS, Wong TP. Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress. J Neurosci. 2019;39:7576–90.
Article PubMed PubMed Central Google Scholar
Diaz V, Lin D. Neural circuits for coping with social defeat. Curr Opin Neurobiol. 2020;60:99–107.
Article CAS PubMed Google Scholar
Willmore L, Cameron C, Yang J, Witten IB, Falkner AL. Behavioural and dopaminergic signatures of resilience. Nature. 2022;611:124–32.
Article CAS PubMed PubMed Central Google Scholar
Colyn L, Venzala E, Marco S, Perez-Otano I, Tordera RM. Chronic social defeat stress induces sustained synaptic structural changes in the prefrontal cortex and amygdala. Behav Brain Res. 2019;373:112079.
Article CAS PubMed Google Scholar
Cook SC, Wellman CL. Chronic stress alters dendritic morphology in rat medial prefrontal cortex. J Neurobiol. 2004;60:236–48.
Schoenfeld TJ, McCausland HC, Morris HD, Padmanaban V, Cameron HA. Stress and loss of adult neurogenesis differentially reduce hippocampal volume. Biol Psychiatry. 2017;82:914–23.
Article PubMed PubMed Central Google Scholar
Conrad CD. Chronic stress-induced hippocampal vulnerability: the glucocorticoid vulnerability hypothesis. Rev Neurosci. 2008;19:395–411.
Article PubMed PubMed Central Google Scholar
Tse YC, Montoya I, Wong AS, Mathieu A, Lissemore J, Lagace DC, et al. A longitudinal study of stress-induced hippocampal volume changes in mice that are susceptible or resilient to chronic social defeat. Hippocampus. 2014;24:1120–8.
Misquitta KA, Miles A, Prevot TD, Knoch JK, Fee C, Newton DF, et al. Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density. Neuropharmacology. 2021;190:108562.
Article CAS PubMed Google Scholar
Catale C, Martini A, Piscitelli RM, Senzasono B, Iacono LL, Mercuri NB, et al. Early-life social stress induces permanent alterations in plasticity and perineuronal nets in the mouse anterior cingulate cortex. Eur J Neurosci. 2022;56:5763–83.
Article CAS PubMed Google Scholar
Nasca C, Bigio B, Zelli D, Nicoletti F, McEwen BS. Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility. Mol Psychiatry. 2015;20:755–63.
Article CAS PubMed Google Scholar
Hitti FL, Siegelbaum SA. The hippocampal CA2 region is essential for social memory. Nature. 2014;508:88–92.
Article CAS PubMed PubMed Central Google Scholar
Smith AS, Williams Avram SK, Cymerblit-Sabba A, Song J, Young WS. Targeted activation of the hippocampal CA2 area strongly enhances social memory. Mol Psychiatry. 2016;21:1137–44.
Article CAS PubMed PubMed Central Google Scholar
Zhao M, Choi YS, Obrietan K, Dudek SM. Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons. J Neurosci. 2007;27:12025–32.
Article CAS PubMed PubMed Central Google Scholar
Kohara K, Pignatelli M, Rivest AJ, Jung HY, Kitamura T, Suh J, et al. Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits. Nat Neurosci. 2014;17:269–79.
Article CAS PubMed Google Scholar
Raam T, McAvoy KM, Besnard A, Veenema AH, Sahay A. Hippocampal oxytocin receptors are necessary for discrimination of social stimuli. Nat Commun. 2017;8:2001.
Article PubMed PubMed Central Google Scholar
Dudek SM, Alexander GM, Farris S. Rediscovering area CA2: unique properties and functions. Nat Rev Neurosci. 2016;17:89–102.
Article CAS PubMed PubMed Central Google Scholar
Meira T, Leroy F, Buss EW, Oliva A, Park J, Siegelbaum SA. A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics. Nat Commun. 2018;9:4163.
Article PubMed PubMed Central Google Scholar
Okuyama T, Kitamura T, Roy DS, Itohara S, Tonegawa S. Ventral CA1 neurons store social memory. Science. 2016;353:1536–41.
Article CAS PubMed PubMed Central Google Scholar
Phillips, ML, HA Robinson, and L Pozzo-Miller, Ventral hippocampal projections to the medial prefrontal cortex regulate social memory. eLife. 2019;8:e44182.
Leroy F, Park J, Asok A, Brann DH, Meira T, Boyle LM, et al. A circuit from hippocampal CA2 to lateral septum disinhibits social aggression. Nature. 2018;564:213–8.
Comments (0)