R.L. Siegel, K.D. Miller, H.E. Fuchs et al., Cancer statistics, 2021. CA Cancer J. Clin. 71, 7–33 (2021)

Article  PubMed  Google Scholar 

A. Thomas, S.V. Liu, D.S. Subramaniam et al., Refining the treatment of NSCLC according to histological and molecular subtypes. Nat. Rev. Clin. Oncol. 12, 511–526 (2015)

Article  CAS  PubMed  Google Scholar 

J. Rotow, T.G. Bivona, Understanding and targeting resistance mechanisms in NSCLC. Nat. Rev. Cancer 17, 637–658 (2017)

Article  CAS  PubMed  Google Scholar 

W.D. Travis, E. Brambilla, G.J. Riely, New pathologic classification of lung cancer: relevance for clinical practice and clinical trials. J. Clin. Oncol. 31, 992–1001 (2013)

Article  CAS  PubMed  Google Scholar 

P. Zhou, B. Li, F. Liu et al., The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer. Mol. Cancer 16, 52 (2017)

Article  PubMed  PubMed Central  Google Scholar 

T.A. d’Amato, R.J. Landreneau, W. Ricketts et al., Chemotherapy resistance and oncogene expression in non-small cell lung cancer. J. Thorac. Cardiovasc. Surg. 133, 352–363 (2007)

Article  PubMed  Google Scholar 

W.J. Liu, Y. Du, R. Wen et al., Drug resistance to targeted therapeutic strategies in non-small cell lung cancer. Pharmacol. Ther. 206, 107438 (2020)

Article  CAS  PubMed  Google Scholar 

A. Kusoglu, C. Biray Avci, Cancer stem cells: a brief review of the current status. Gene 681, 80–85 (2019)

Article  CAS  PubMed  Google Scholar 

T. Lapidot, C. Sirard, J. Vormoor et al., A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645–648 (1994)

Article  CAS  PubMed  Google Scholar 

Y. Zhang, W. Xu, H. Guo et al., NOTCH1 signaling regulates self-renewal and platinum chemoresistance of cancer stem-like cells in human non-small cell lung cancer. Cancer Res. 77, 3082–3091 (2017)

Article  CAS  PubMed  Google Scholar 

Y. Zhang, F. Qiu, T. Ye et al., Epiregulin increases stemness-associated genes expression and promotes chemoresistance of non-small cell lung cancer via ERK signaling. Stem Cell Res. Ther. 13, 197 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

W.J. Huang, S. Ruan, F. Wen et al., Multidrug resistance of gastric cancer: the mechanisms and Chinese medicine reversal agents. Cancer Manag. Res. 12, 12385–12394 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y. Zhao, C. Tang, J. Huang et al., Screening multidrug resistance reversal agents in traditional Chinese medicines by Efflux Kinetics of D-luciferin in MCF-7/DOX(Fluc) cells. ACS Omega 8, 4853–4861 (2023)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J.S. Lou, P. Yao, K.W.K. Tsim, Cancer treatment by using traditional Chinese medicine: probing active compounds in anti-multidrug resistance during drug therapy. Curr. Med. Chem. 25, 5128–5141 (2018)

Article  CAS  PubMed  Google Scholar 

L. Chen, Y.X. Xu, Y.S. Wang et al., Integrative Chinese-Western medicine strategy to overcome docetaxel resistance in prostate cancer. J. Ethnopharmacol. 331, 118265 (2024)

Article  CAS  PubMed  Google Scholar 

Q. Zhang, Y. Feng, D. Kennedy, Multidrug-resistant cancer cells and cancer stem cells hijack cellular systems to circumvent systemic therapies, can natural products reverse this? Cell Mol. Life Sci. 74, 777–801 (2017)

Article  CAS  PubMed  Google Scholar 

M. Kartal-Yandim, A. Adan-Gokbulut, Y. Baran, Molecular mechanisms of drug resistance and its reversal in cancer. Crit. Rev. Biotechnol. 36, 716–726 (2016)

Article  CAS  PubMed  Google Scholar 

E. Fathi, I. Vietor, Mesenchymal stem cells promote caspase expression in Molt-4 Leukemia cells via GSK-3alpha/Beta and ERK1/2 signaling pathways as a therapeutic strategy. Curr. Gene. Ther. 21, 81–88 (2021)

Article  CAS  PubMed  Google Scholar 

W. Zeng, J.F. Zhu, J. Guo et al., m(6)A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation. Cell Death Dis. 13, 1008 (2022)

Article  PubMed  PubMed Central  Google Scholar 

H. Zhao, C. Yan, Y. Hu et al., Sphereforming assay vs. organoid culture: determining longterm stemness and the chemoresistant capacity of primary colorectal cancer cells. Int. J. Oncol. 54, 893–904 (2019)

CAS  PubMed  PubMed Central  Google Scholar 

C. Wu, L. Chen, H. Tao et al., RING finger protein 38 induces the drug resistance of cisplatin in non-small-cell lung cancer. Cell Biol. Int. 45, 287–294 (2021)

Article  CAS  PubMed  Google Scholar 

K. Adibkia, A. Ehsani, A. Jodaei et al., Silver nanoparticles induce the cardiomyogenic differentiation of bone marrow derived mesenchymal stem cells via telomere length extension. Beilstein J. Nanotechnol. 12, 786–797 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

E. Fathi, R. Farahzadi, B. Valipour, Alginate/gelatin encapsulation promotes NK cells differentiation potential of bone marrow resident C-kit(+) hematopoietic stem cells. Int. J. Biol. Macromol. 177, 317–327 (2021)

Article  CAS  PubMed  Google Scholar 

W. Xu, S.H. Lee, F. Qiu et al., Association of SMAD4 loss with drug resistance in clinical cancer patients: a systematic meta-analysis. PLoS One 16, e0250634 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

C. Shan, D. Ou, Y. Xiong et al., Molecular mechanism of anti-inflammatory effects of the proteasome inhibitor MG-132 on Con A-induced acute liver injury in mice. Res. Vet. Sci. 156, 60–65 (2023)

Article  CAS  PubMed  Google Scholar 

A. Martinez-Ferriz, A. Ferrando, A. Fathinajafabadi et al., Ubiquitin-mediated mechanisms of translational control. Semin. Cell Dev. Biol. 132, 146–154 (2022)

Article  CAS  PubMed  Google Scholar 

J.B. Cordero, O.J. Sansom, Wnt signalling and its role in stem cell-driven intestinal regeneration and hyperplasia. Acta Physiol. (Oxf) 204, 137–143 (2012)

Article  CAS  PubMed  Google Scholar 

N. Takebe, L. Miele, P.J. Harris et al., Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update. Nat. Rev. Clin. Oncol. 12, 445–464 (2015)

Article  CAS  PubMed  PubMed Central  Google Scholar 

C. Schug, S. Urnauer, C. Jaeckel et al., TGFB1-driven mesenchymal stem cell-mediated NIS gene transfer. Endocr. Relat. Cancer 26, 89–101 (2019)

Article  CAS  PubMed  Google Scholar 

F. Qi, A. Li, Y. Inagaki et al., Chinese herbal medicines as adjuvant treatment during chemo- or radio-therapy for cancer. Biosci. Trends 4, 297–307 (2010)

PubMed  Google Scholar 

W. Zhang, Y. Zhao, H. Liu et al., Efficacy of Traditional Chinese medicine combined with chemotherapy in the treatment of gastric cancer: a meta-analysis. Comput. Math. Methods Med. 2022, 8497084 (2022)

PubMed  PubMed Central