Gettinger S, Horn L, Jackman D et al (2018) Five-year follow-up of nivolumab in previously treated advanced non-small-cell lung cancer: Results from the Ca209-003 study. J Clin Oncol 36(17):1675–1684. https://doi.org/10.1200/jco.2017.77.0412
Article PubMed CAS Google Scholar
Knight A, Karapetyan L, Kirkwood JM (2023) Immunotherapy in melanoma: Recent advances and future directions. Cancers (Basel) 15(4):1106. https://doi.org/10.3390/cancers15041106
Article PubMed CAS Google Scholar
Blumenthal GM, Zhang L, Zhang H et al (2017) Milestone analyses of immune checkpoint inhibitors, targeted therapy, and conventional therapy in metastatic non-small cell lung cancer trials: a meta-analysis. JAMA Oncol 3(8):e171029. https://doi.org/10.1001/jamaoncol.2017.1029
Article PubMed PubMed Central Google Scholar
Yarchoan M, Hopkins A, Jaffee EM (2017) Tumor mutational burden and response rate to Pd-1 inhibition. N Engl J Med 377(25):2500–2501. https://doi.org/10.1056/NEJMc1713444
Article PubMed PubMed Central Google Scholar
Reck M, Rodríguez-Abreu D, Robinson AG et al (2016) Pembrolizumab versus chemotherapy for Pd-L1-positive non-small-cell lung cancer. N Engl J Med 375(19):1823–1833. https://doi.org/10.1056/NEJMoa1606774
Article PubMed CAS Google Scholar
VanderWalde A, Bellasea SL, Kendra KL et al (2023) Ipilimumab with or without Nivolumab in Pd-1 or Pd-L1 blockade refractory metastatic melanoma: A randomized phase 2 trial. Nat Med 29(9):2278–2285. https://doi.org/10.1038/s41591-023-02498-y
Article PubMed PubMed Central CAS Google Scholar
Moeckel C, Bakhl K, Georgakopoulos-Soares I et al (2023) The Efficacy of tumor mutation burden as a biomarker of response to immune checkpoint inhibitors. Int J Mol Sci 24(7):6710. https://doi.org/10.3390/ijms24076710
Article PubMed PubMed Central CAS Google Scholar
Dong ZY, Zhong WZ, Zhang XC et al (2017) Potential Predictive Value of Tp53 and kras mutation status for response to Pd-1 blockade immunotherapy in lung adenocarcinoma. Clin Cancer Res 23(12):3012–3024. https://doi.org/10.1158/1078-0432.Ccr-16-2554
Article PubMed CAS Google Scholar
Dong Y, Zhao L, Duan J et al (2022) Pappa2 mutation as a novel indicator stratifying beneficiaries of immune checkpoint inhibitors in skin cutaneous melanoma and non-small cell lung cancer. Cell Prolif 55(9):e13283. https://doi.org/10.1111/cpr.13283
Article PubMed PubMed Central CAS Google Scholar
Chudnovsky Y, Kim D, Zheng S et al (2014) Zfhx4 interacts with the nurd Core Member Chd4 and regulates the glioblastoma tumor-initiating cell state. Cell Rep 6(2):313–324. https://doi.org/10.1016/j.celrep.2013.12.032
Article PubMed PubMed Central CAS Google Scholar
Zong S, Xu PP, Xu YH et al (2022) A bioinformatics analysis: Zfhx4 is associated with metastasis and poor survival in ovarian cancer. J Ovarian Res 15(1):90. https://doi.org/10.1186/s13048-022-01024-x
Article PubMed PubMed Central CAS Google Scholar
Ha M, Kim J, Park SM et al (2020) Prognostic role of zinc finger homeobox 4 in ovarian serous cystadenocarcinoma. Genet Test Mol Biomarkers 24(3):145–149. https://doi.org/10.1089/gtmb.2019.0185
Article PubMed CAS Google Scholar
Qing T, Zhu S, Suo C et al (2017) Somatic mutations in Zfhx4 gene are associated with poor overall survival of chinese esophageal squamous cell carcinoma patients. Sci Rep 7(1):4951. https://doi.org/10.1038/s41598-017-04221-7
Article PubMed PubMed Central CAS Google Scholar
Hellmann MD, Nathanson T, Rizvi H et al (2018) Genomic features of response to combination immunotherapy in patients with advanced non-small-cell lung cancer. Cancer Cell 33(5):843-852.e844. https://doi.org/10.1016/j.ccell.2018.03.018
Article PubMed PubMed Central CAS Google Scholar
Rizvi NA, Hellmann MD, Snyder A et al (2015) Cancer immunology. Mutational landscape determines sensitivity to Pd-1 blockade in non-small cell lung cancer. Science 348(6230):124–128. https://doi.org/10.1126/science.aaa1348
Article PubMed PubMed Central CAS Google Scholar
Miao D, Margolis CA, Vokes NI et al (2018) Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors. Nat Genet 50(9):1271–1281. https://doi.org/10.1038/s41588-018-0200-2
Article PubMed PubMed Central CAS Google Scholar
Hoadley KA, Yau C, Hinoue T et al (2018) Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer. Cell 173(2):291-304.e296. https://doi.org/10.1016/j.cell.2018.03.022
Article PubMed PubMed Central CAS Google Scholar
Charoentong P, Finotello F, Angelova M et al (2017) Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell Rep 18(1):248–262. https://doi.org/10.1016/j.celrep.2016.12.019
Article PubMed CAS Google Scholar
Thorsson V, Gibbs DL, Brown SD et al (2018) The immune landscape of cancer. Immunity 48(4):812-830.e814. https://doi.org/10.1016/j.immuni.2018.03.023
Article PubMed PubMed Central CAS Google Scholar
Roh W, Chen PL, Reuben A et al (2017) Integrated Molecular Analysis of Tumor Biopsies on Sequential Ctla-4 and Pd-1 Blockade Reveals Markers of Response and Resistance. Sci Transl Med 9(379):eaah3560. https://doi.org/10.1126/scitranslmed.aah3560
Article PubMed PubMed Central CAS Google Scholar
Riaz N, Havel JJ, Makarov V et al (2017) Tumor and microenvironment evolution during immunotherapy with nivolumab. Cell 171(4):934-949.e916. https://doi.org/10.1016/j.cell.2017.09.028
Article PubMed PubMed Central CAS Google Scholar
Liu D, Schilling B, Liu D et al (2019) Integrative molecular and clinical modeling of clinical outcomes to pd1 blockade in patients with metastatic melanoma. Nat Med 25(12):1916–1927. https://doi.org/10.1038/s41591-019-0654-5
Article PubMed PubMed Central CAS Google Scholar
Hugo W, Zaretsky JM, Sun L et al (2016) Genomic and transcriptomic features of response to anti-pd-1 therapy in metastatic melanoma. Cell 165(1):35–44. https://doi.org/10.1016/j.cell.2016.02.065
Article PubMed PubMed Central CAS Google Scholar
Miao W, Li L, Wang Y (2018) A targeted proteomic approach for heat shock proteins reveals dnajb4 as a suppressor for melanoma metastasis. Anal Chem 90(11):6835–6842. https://doi.org/10.1021/acs.analchem.8b00986
Article PubMed PubMed Central CAS Google Scholar
Van Allen EM, Miao D, Schilling B et al (2015) Genomic correlates of response to ctla-4 blockade in metastatic melanoma. Science 350(6257):207–211. https://doi.org/10.1126/science.aad0095
Article PubMed PubMed Central CAS Google Scholar
Samstein RM, Lee CH, Shoushtari AN et al (2019) Tumor mutational load predicts survival after immunotherapy across multiple cancer types. Nat Genet 51(2):202–206. https://doi.org/10.1038/s41588-018-0312-8
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