Sherman WJ, Romiti E, Michaelides L, Moniz-Garcia D, Chaichana KL, Quinones-Hinojosa A, Porter AB (2023) Systemic therapy for melanoma brain and leptomeningeal metastases. Curr Treat Options Oncol 24:1962–1977
Patel H, Yacoub N, Mishra R, White A, Yuan L, Alanazi S, Garrett JT (2020) Current advances in the treatment of BRAF-mutant melanoma. Cancers 12:482
Article CAS PubMed PubMed Central Google Scholar
Sinclair R, Wong XL, Shumack S, Baker C, Macmahon B (2024) The role of micrometastasis in high-risk skin cancers. Australas J Dermatol 65:143–152
Bong CY, Smithers BM, Chua TC (2021) Pulmonary metastasectomy in the era of targeted therapy and immunotherapy. J Thorac Dis 13:2618–2627
Article PubMed PubMed Central Google Scholar
Switzer B, Puzanov I, Skitzki JJ, Hamad L, Ernstoff MS (2022) Managing metastatic melanoma in 2022: a clinical review. JCO Oncol Pract 18:335–351
Article PubMed PubMed Central Google Scholar
Cazzato G, Ingravallo G, Ribatti D (2024) Angiogenesis still plays a crucial role in human melanoma progression. Cancers 16:1794
Article CAS PubMed PubMed Central Google Scholar
Lei X, Lei Y, Li JK, Du WX, Li RG, Yang J, Li J, Li F, Tan HB (2020) Immune cells within the tumor microenvironment: biological functions and roles in cancer immunotherapy. Cancer Lett 470:126–133
Article CAS PubMed Google Scholar
DeBerardinis RJ, Chandel NS (2016) Fundamentals of cancer metabolism. Sci Adv 2:e1600200
Article PubMed PubMed Central Google Scholar
Gazzillo A, Polidoro MA, Soldani C, Franceschini B, Lleo A, Donadon M (2022) Relationship between epithelial-to-mesenchymal transition and tumor-associated macrophages in colorectal liver metastases. Int J Mol Sci 23:16197
Article CAS PubMed PubMed Central Google Scholar
Olguin JE, Medina-Andrade I, Rodriguez T, Rodriguez-Sosa M, Terrazas LI (2020) Relevance of regulatory T cells during colorectal cancer development. Cancers 12:1888
Article CAS PubMed PubMed Central Google Scholar
Kong F, Chen T, Li X, Jia Y (2021) The current application and future prospects of Astragalus polysaccharide combined with cancer immunotherapy: a review. Front Pharmacol 12:737674
Article CAS PubMed PubMed Central Google Scholar
Zhou L, Liu Z, Wang Z, Yu S, Long T, Zhou X, Bao Y (2017) Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo. Sci Rep 7:44822
Article CAS PubMed PubMed Central Google Scholar
Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R (2013) Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling. J Biol Chem 288:7430–7437
Article CAS PubMed PubMed Central Google Scholar
Hayuningtyas RA, Han M, Choi S, Kwak MS, Park IH, Lee J-H, Choi JE, Kim DK, Son M, Shin JS (2021) The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2. Mol Med 27:125
Article CAS PubMed PubMed Central Google Scholar
Lugovic-Mihic L, Cesic D, Vukovic P, Bilic GN, Situm M, Spoljar S (2019) Melanoma development: current knowledge on melanoma pathogenesis. Acta Dermatovenerol Croat 27:163–168
Gao Y, Zhou J, Li J (2021) Discoidin domain receptors orchestrate cancer progression: a focus on cancer therapies. Cancer Sci 112:962–969
Article CAS PubMed PubMed Central Google Scholar
Trono P, Ottavi F, Rosano L (2024) Novel insights into the role of discoidin domain receptor 2 (DDR2) in cancer progression: a new avenue of therapeutic intervention. Matrix Biol 125:31–39
Article CAS PubMed Google Scholar
Sala M, Allain N, Moreau M, Jabouille A, Henriet E, Abou-Hammoud A, Uguen A, Di-Tommaso S, Dourthe C, Raymond AA et al (2022) Discoidin domain receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation. Oncogene 41:2571–2586
Article CAS PubMed Google Scholar
Zhang S, Bu X, Zhao H, Yu J, Wang Y, Li D, Zhu C, Zhu T, Ren T, Liu X et al (2014) A host deficiency of discoidin domain receptor 2 (DDR2) inhibits both tumour angiogenesis and metastasis. J Pathol 232:436–448
Article CAS PubMed Google Scholar
Klingen TA, Chen Y, Aas H, Akslen LA (2024) DDR2 expression in breast cancer is associated with blood vessel invasion, basal-like tumors, tumor-associated macrophages, regulatory T cells, detection mode and prognosis. Hum Pathol 150:9–35
Romayor I, Luque Garcia-Vaquero M, Marquez J, Arteta B, Barcelo R, Benedicto A (2022) Discoidin domain receptor 2 expression as worse prognostic marker in invasive breast cancer. Breast J 2022:5169405
Article PubMed PubMed Central Google Scholar
Liu Q, Wang X, Chen Y, Ma X, Kang X, He F, Feng D, Zhang Y (2023) Ablation of myeloid discoidin domain receptor 2 exacerbates arthritis and high fat diet induced inflammation. Biochem Biophys Res Commun 649:47–54
Article CAS PubMed Google Scholar
Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, Kovatich AJ, Benz CC, Levine DA, Lee AV et al (2018) An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics. Cell 173:400–416
Article CAS PubMed PubMed Central Google Scholar
Hothorn T. and Lausen B.(2002). Maximally selected rank statistics in R. Biometr J , 44.
Zhang Z, Lin E, Zhuang H, Xie L, Feng X, Liu J, Yu Y (2020) Construction of a novel gene-based model for prognosis prediction of clear cell renal cell carcinoma. Cancer Cell Int 20:27
Article PubMed PubMed Central Google Scholar
Wei J, Huang K, Chen Z, Hu M, Bai Y, Lin S, Du H (2020) Characterization of glycolysis-associated molecules in the tumor microenvironment revealed by pan-cancer tissues and lung cancer single cell data. Cancers 12:1788
Article CAS PubMed PubMed Central Google Scholar
Tagliaferri L, Lancellotta V, Fionda B, Mangoni M, Casa C, Di Stefani A, Pagliara MM, D’Aviero A, Schinzari G, Chiesa S et al (2022) Immunotherapy and radiotherapy in melanoma: a multidisciplinary comprehensive review. Hum Vaccin Immunother 18:1903827
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229–263
Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023. CA Cancer J Clin 73:17–48
Garbe C, Peris K, Hauschild A, Saiag P, Middleton M, Bastholt L, Grob J-J, Malvehy J, Newton-Bishop J, Stratigos AJ et al (2016) Diagnosis and treatment of melanoma. European consensus-based interdisciplinary guideline – Update 2016. Eur J Cancer 63:201–217
Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, Daud A, Carlino MS, McNeil C, Lotem M et al (2015) Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 372:2521–2532
Comments (0)