Assay for interferon gamma release as a novel marker in pediatric patients with systemic lupus erythematosus

Fernando MM, Freudenberg J, Lee A, Morris DL, Boteva L, Rhodes B, et al. Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G. Ann Rheum Dis. 2012;71(5):777–84. https://doi.org/10.1136/annrheumdis-2011-200808.

Article  CAS  PubMed  Google Scholar 

Wilkinson MGL, Rosser EC. B cells as a therapeutic target in Paediatric Rheumatic Disease. Front Immunol. 2019;10:214. https://doi.org/10.3389/fimmu.2019.00214.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pascual V, Farkas L, Banchereau J. Systemic lupus erythematosus: all roads lead to type I interferons. Curr Opin Immunol. 2006;18(6):676–82. https://doi.org/10.1016/j.coi.2006.09.014.

Article  CAS  PubMed  Google Scholar 

Dall’era MC, Cardarelli PM, Preston BT, Witte A, Davis JC. Type I interferon correlates with serological and clinical manifestations of SLE. Ann Rheum Dis. 2005;64(12):1692–7. https://doi.org/10.1136/ard.2004.033753.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jahromi AS, Zar A, Ahmadi F, Krustrup P, Ebrahim K, Hovanloo F, et al. Effects of endurance training on the serum levels of Tumour Necrosis Factor-α and Interferon-γ in sedentary men. Immune Netw. 2014;14(5):255–9. https://doi.org/10.4110/in.2014.14.5.255.

Article  PubMed  PubMed Central  Google Scholar 

Teichmann LL, Schenten D, Medzhitov R, Kashgarian M, Shlomchik MJ. Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity. 2013;38(3):528–40. https://doi.org/10.1016/j.immuni.2012.11.017.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karonitsch T, Feierl E, Steiner CW, Dalwigk K, Korb A, Binder N, et al. Activation of the interferon-gamma signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells. Arthritis Rheum. 2009;60(5):1463–71. https://doi.org/10.1002/art.24449.

Article  PubMed  Google Scholar 

Rubio J, Kyttaris VC. Measuring IFN activity in suspected SLE: a valuable step? Expert Rev Clin Immu. 2021;17(6):545–8. https://doi.org/10.1080/1744666X.2021.1912597.

Article  CAS  Google Scholar 

Gibson L. An Interferon-γ release assay for evaluation of cell-mediated immunity in infants with congenital cytomegalovirus infection. Clin Infect Dis. 2021;73(3):374–5. https://doi.org/10.1093/cid/ciaa700.

Article  PubMed  Google Scholar 

Guavita-Navarro D, Gallego-Cardona L, Arredondo AM, Cubides H, Cajamarca-Barón J, Ibáñez C, et al. Comparison of the sensitivity of the EULAR / ACR 2019 and SLICC 2012 classification criteria in a Colombian population with systemic lupus erythematosus. J Transl Autoimmun. 2021;4:100133. https://doi.org/10.1016/j.jtauto.2021.100133.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Whittall Garcia LP, Gladman DD, Urowitz M, Touma Z, Su J, Johnson SR. New EULAR/ACR 2019 SLE classification criteria: defining ominosity in SLE. Ann Rheum Dis. 2021;80(6):767–74. https://doi.org/10.1136/annrheumdis-2020-218670. Epub 2021 Jan 15.

Article  CAS  PubMed  Google Scholar 

Thomason JL, Obih UM, Koelle DM, Lood C, Hughes AG. An interferon-gamma release assay as a novel biomarker in systemic lupus erythematosus. Rheumatology. 2020;59(11):3479–87. https://doi.org/10.1093/rheumatology/keaa161.

Article  CAS  PubMed  Google Scholar 

Byrd TF, Horwitz MA. Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gamma. J Clin Invest. 1993;91(3):969–76. https://doi.org/10.1172/JCI116318.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tripathy R, Panda AK, Das BK. Serum ferritin level correlates with SLEDAI scores and renal involvement in SLE. Lupus. 2014;24(1):82–9. https://doi.org/10.1177/0961203314552290.

Article  CAS  PubMed  Google Scholar 

Handono K, Wahono CS, Pratama MZ, Kalim H. Association of the premature immunosenescence with the presence and severity of anemia among patients with systemic lupus erythematosus. Lupus. 2021;30(12):1906–14. https://doi.org/10.1177/09612033211038057.

Article  CAS  PubMed  Google Scholar 

Rovin BH, Lu L, Zhang X. A novel interleukin-8 polymorphism is associated with severe systemic lupus erythematosus nephritis. Kidney Int. 2002;62(1):261–5. https://doi.org/10.1046/j.1523-1755.2002.00438.x.

Article  CAS  PubMed  Google Scholar 

Yoshio T, Okamoto H, Kurasawa K, Dei Y, Hirohata S, Minota S. IL-6, IL-8, IP-10, MCP-1 and G-CSF are significantly increased in cerebrospinal fluid but not in sera of patients with central neuropsychiatric lupus erythematosus. Lupus. 2016;25(9):997–1003. https://doi.org/10.1177/0961203316629556.

Article  CAS  PubMed  Google Scholar 

Bengtsson AA, Sturfelt G, Truedsson L, Blomberg J, Alm G, Vallin H, et al. Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies. Lupus. 2000;9(9):664–71. https://doi.org/10.1191/096120300674499064.

Article  CAS  PubMed  Google Scholar 

Munroe ME, Lu R, Zhao YD, Fife DA, Robertson JM, Guthridge JM, et al. Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification. Ann Rheum Dis. 2016;75(11):2014–21. https://doi.org/10.1136/annrheumdis-2015-208140.

Article  CAS  PubMed  Google Scholar 

Oke V, Gunnarsson I, Dorschner J, Eketjäll S, Zickert A, Niewold TB, et al. High levels of circulating interferons type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus. Arthritis Res Ther. 2019;21(1):107. https://doi.org/10.1186/s13075-019-1878-y.

Article  PubMed  PubMed Central  Google Scholar 

El-Shehaby A, Darweesh H, El-Khatib M, Momtaz M, Marzouk S, El-Shaarawy N, et al. Correlations of urinary biomarkers, TNF-like weak inducer of apoptosis (TWEAK), osteoprotegerin (OPG), monocyte chemoattractant protein-1 (MCP-1), and IL-8 with lupus nephritis. J Clin Immunol. 2011;31(5):848–56. https://doi.org/10.1007/s10875-011-9555-1.

Article  CAS  PubMed  Google Scholar 

Oke V, Brauner S, Larsson A, Gustafsson J, Zickert A, Gunnarsson I, et al. IFN-λ1 with Th17 axis cytokines and IFN-α define different subsets in systemic lupus erythematosus (SLE). Arthritis Res Ther. 2017;19(1):139. https://doi.org/10.1186/s13075-017-1344-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rana A, Minz RW, Aggarwal R, Anand S, Pasricha N, Singh S. Gene expression of cytokines (TNF-α, IFN-γ), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus. Lupus. 2012;21(10):1105–12. https://doi.org/10.1177/0961203312451200.

Article  CAS  PubMed  Google Scholar 

Cai Z, Zhang S, Wu P, et al. A novel potential target of IL-35-regulated JAK/STAT signaling pathway in lupus nephritis. Clin Transl Med. 2021;11(2):e309. https://doi.org/10.1002/ctm2.309.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng X, Wu H, Grossman JM, Hanvivadhanakul P, FitzGerald JD, Park GS, et al. Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis Rheum. 2006;54(9):2951–62. https://doi.org/10.1002/art.22044.

Article  CAS  PubMed  Google Scholar 

Smith S, Fernando T, Wu PW, Seo J, Ní Gabhann J, Piskareva O, et al. MicroRNA-302d targets IRF9 to regulate the IFN-induced gene expression in SLE. J Autoimmun. 2017;79:105–11. https://doi.org/10.1016/j.jaut.2017.03.003.

Article  CAS 

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