1Medicine, Renal-Electrolyte Division

2Medicine, Division of Endocrinology and Metabolism

3Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania

4the Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York

5Current affiliation: Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

aCorrespondence: Prof. Ossama Kashlan, Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh, S828B Scaife Hall, 3550 Terrace St., Pittsburgh, Pennsylvania 15261, Telephone: (412)648-9275; E-mail: [email protected]

*These authors contributed equally