WHO Coronavirus (COVID-19.) Dashboard [Internet]. [cited 2023 Mar 10]. Available from: https://covid19.who.int.

Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, Pérez Marc G, Moreira ED, Zerbini C, Bailey R, Swanson KA, Roychoudhury S, Koury K, Li P, Kalina WV, Cooper D, Frenck RW Jr, Hammitt LL, Türeci Ö, Nell H, Schaefer A, Ünal S, Tresnan DB, Mather S, Dormitzer PR, Şahin U, Jansen KU, Gruber WC. C4591001 Clinical Trial Group. Safety and Efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383(27):2603–15. https://doi.org/10.1056/NEJMoa2034577. Epub 2020 Dec 10. PMID: 33301246; PMCID: PMC7745181.

Article  CAS  PubMed  Google Scholar 

Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, Diemert D, Spector SA, Rouphael N, Creech CB, McGettigan J, Khetan S, Segall N, Solis J, Brosz A, Fierro C, Schwartz H, Neuzil K, Corey L, Gilbert P, Janes H, Follmann D, Marovich M, Mascola J, Polakowski L, Ledgerwood J, Graham BS, Bennett H, Pajon R, Knightly C, Leav B, Deng W, Zhou H, Han S, Ivarsson M, Miller J, Zaks T, COVE Study Group. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384(5):403–16. https://doi.org/10.1056/NEJMoa2035389. Epub 2020 Dec 30. PMID: 33378609; PMCID: PMC7787219.

Article  CAS  PubMed  Google Scholar 

Self WH, Tenforde MW, Rhoads JP, Gaglani M, Ginde AA, Douin DJ, Olson SM, Talbot HK, Casey JD, Mohr NM, Zepeski A, McNeal T, Ghamande S, Gibbs KW, Files DC, Hager DN, Shehu A, Prekker ME, Erickson HL, Gong MN, Mohamed A, Henning DJ, Steingrub JS, Peltan ID, Brown SM, Martin ET, Monto AS, Khan A, Hough CL, Busse LW, Ten Lohuis CC, Duggal A, Wilson JG, Gordon AJ, Qadir N, Chang SY, Mallow C, Rivas C, Babcock HM, Kwon JH, Exline MC, Halasa N, Chappell JD, Lauring AS, Grijalva CG, Rice TW, Jones ID, Stubblefield WB, Baughman A, Womack KN, Lindsell CJ, Hart KW, Zhu Y, Mills L, Lester SN, Stumpf MM, Naioti EA, Kobayashi M, Verani JR, Thornburg NJ, Patel MM, IVY Network. Comparative effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & Johnson) vaccines in preventing COVID-19 hospitalizations among adults without Immunocompromising conditions - United States, March-August 2021. MMWR Morb Mortal Wkly Rep. 2021;70(38):1337–43. https://doi.org/10.15585/mmwr.mm7038e1. PMID: 34555004; PMCID: PMC8459899.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Commissioner O. of the. Pfizer-BioNTech COVID-19 Vaccines. FDA [Internet]. 2023 Mar 16 [cited 2023 Mar 16]; Available from: https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/pfizer-biontech-covid-19-vaccines.

Commissioner O. of the. Moderna COVID-19 Vaccines. FDA [Internet]. 2023 Mar 13 [cited 2023 Mar 16]; Available from: https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/moderna-covid-19-vaccines.

CDC COVID-19 Vaccine Breakthrough Case Investigations Team. COVID-19 vaccine breakthrough infections reported to CDC - United States, January 1-April 30, 2021. MMWR Morb Mortal Wkly Rep. 2021;70(21):792–3. https://doi.org/10.15585/mmwr.mm7021e3. PMID: 34043615; PMCID: PMC8158893.

Article  PubMed Central  Google Scholar 

Bergwerk M, Gonen T, Lustig Y, Amit S, Lipsitch M, Cohen C, Mandelboim M, Levin EG, Rubin C, Indenbaum V, Tal I, Zavitan M, Zuckerman N, Bar-Chaim A, Kreiss Y, Regev-Yochay G. Covid-19 breakthrough infections in Vaccinated Health Care workers. N Engl J Med. 2021;385(16):1474–84. https://doi.org/10.1056/NEJMoa2109072. Epub 2021 Jul 28. PMID: 34320281; PMCID: PMC8362591.

Article  CAS  PubMed  Google Scholar 

Liu C, Lee J, Ta C, Soroush A, Rogers JR, Kim JH, Natarajan K, Zucker J, Perl Y, Weng C. Risk factors Associated with SARS-CoV-2 breakthrough infections in fully mRNA-Vaccinated individuals: retrospective analysis. JMIR Public Health Surveill. 2022;8(5):e35311. https://doi.org/10.2196/35311. PMID: 35486806; PMCID: PMC9132195.

Article  PubMed  PubMed Central  Google Scholar 

Butt AA, Khan T, Yan P, Shaikh OS, Omer SB, Mayr F. Rate and risk factors for breakthrough SARS-CoV-2 infection after vaccination. J Infect. 2021;83(2):237–79.

Article  PubMed  PubMed Central  Google Scholar 

Wang L, Wang Q, Davis PB, Volkow ND, Xu R. Increased risk for COVID-19 breakthrough infection in fully vaccinated patients with substance use disorders in the United States between December 2020 and August 2021. World Psychiatry Off J World Psychiatr Assoc WPA; 2021.

Puranik A, Lenehan PJ, Silvert E, Niesen MJM, Corchado-Garcia J, O’Horo JC, Virk A, Swift MD, Halamka J, Badley AD, Venkatakrishnan AJ, Soundararajan V. Comparison of two highly-effective mRNA vaccines for COVID-19 during periods of alpha and Delta variant prevalence. medRxiv [Preprint]. 2021 Aug 21:2021.08.06.21261707. https://doi.org/10.1101/2021.08.06.21261707. PMID: 34401884; PMCID: PMC8366801.

Juthani PV, Gupta A, Borges KA, Price CC, Lee AI, Won CH, Chun HJ. Hospitalisation among vaccine breakthrough COVID-19 infections. Lancet Infect Dis. 2021;21(11):1485–1486. doi: 10.1016/S1473-3099(21)00558-2. Epub 2021 Sep 7. Erratum in: Lancet Infect Dis. 2022;22(1):e1. PMID: 34506735; PMCID: PMC8423430.

Moline HL. Effectiveness of COVID-19 Vaccines in Preventing Hospitalization Among Adults Aged ≥ 65 Years — COVID-NET, 13 States, February–April 2021. MMWR Morb Mortal Wkly Rep [Internet]. 2021 [cited 2021 Nov 6];70. Available from: https://www.cdc.gov/mmwr/volumes/70/wr/mm7032e3.htm.

Bosch W, Cowart JB, Bhakta S, Carter RE, Wadei HM, Shah SZ, Sanghavi DK, Pollock BD, Neville MR, Oman SP, Speicher L, Scindia AD, Matson MW. Moreno Franco P. Coronavirus Disease 2019 vaccine-breakthrough infections requiring hospitalization in Mayo Clinic Florida through August 2021. Clin Infect Dis. 2022;75(1):e892–4. https://doi.org/10.1093/cid/ciab932. PMID: 34726700; PMCID: PMC8689905.

Article  PubMed  Google Scholar 

Wang SY, Juthani PV, Borges KA, Shallow MK, Gupta A, Price C, Won CH, Chun HJ. Severe breakthrough COVID-19 cases in the SARS-CoV-2 delta (B.1.617.2) variant era. Lancet Microbe. 2022;3(1):e4–e5. https://doi.org/10.1016/S2666-5247(21)00306-2. Epub 2021 Dec 3. PMID: 34901896; PMCID: PMC8641954.

Article  CAS  PubMed  Google Scholar 

Brosh-Nissimov T, Orenbuch-Harroch E, Chowers M, Elbaz M, Nesher L, Stein M, Maor Y, Cohen R, Hussein K, Weinberger M, Zimhony O, Chazan B, Najjar R, Zayyad H, Rahav G, Wiener-Well Y. BNT162b2 vaccine breakthrough: clinical characteristics of 152 fully vaccinated hospitalized COVID-19 patients in Israel. Clin Microbiol Infect. 2021;27(11):1652–7. Epub 2021 Jul 7. PMID: 34245907; PMCID: PMC8261136.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalligeros M, Shehadeh F, Mylona EK, Kaczynski M, Kalagara S, Atalla E, Tsikala Vafea M, Mylonakis E. Clinical outcomes of adult patients hospitalized with COVID-19 after vaccination. Trop Med Infect Dis. 2021;6(4):175. https://doi.org/10.3390/tropicalmed6040175. PMID: 34698280; PMCID: PMC8544707.

Article  PubMed  PubMed Central  Google Scholar 

Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.

Article  CAS  PubMed  Google Scholar 

WHO-2019-nCoV. -clinical-2020.5-eng.pdf [Internet]. [cited 2023 Mar 16]. Available from: https://apps.who.int/iris/bitstream/handle/10665/332196/WHO-2019-nCoV-clinical-2020.5-eng.pdf?sequence=1&isAllowed=y.

Farid E, Herrera-Uribe J, Stevenson NJ. The effect of age, gender and comorbidities upon SARS-CoV-2 spike antibody induction after two doses of Sinopharm Vaccine and the Effect of a Pfizer/BioNtech Booster Vaccine. Front Immunol. 2022;13:817597. https://doi.org/10.3389/fimmu.2022.817597. PMID: 35711448; PMCID: PMC9197101.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tenforde MW, Self WH, Adams K, Gaglani M, Ginde AA, McNeal T, Ghamande S, Douin DJ, Talbot HK, Casey JD, Mohr NM, Zepeski A, Shapiro NI, Gibbs KW, Files DC, Hager DN, Shehu A, Prekker ME, Erickson HL, Exline MC, Gong MN, Mohamed A, Henning DJ, Steingrub JS, Peltan ID, Brown SM, Martin ET, Monto AS, Khan A, Hough CL, Busse LW, Ten Lohuis CC, Duggal A, Wilson JG, Gordon AJ, Qadir N, Chang SY, Mallow C, Rivas C, Babcock HM, Kwon JH, Halasa N, Chappell JD, Lauring AS, Grijalva CG, Rice TW, Jones ID, Stubblefield WB, Baughman A, Womack KN, Rhoads JP, Lindsell CJ, Hart KW, Zhu Y, Olson SM, Kobayashi M, Verani JR, Patel MM. Influenza and other viruses in the acutely ill (IVY) network. Association between mRNA vaccination and COVID-19 hospitalization and Disease Severity. JAMA. 2021;326(20):2043–54. https://doi.org/10.1001/jama.2021.19499. PMID: 34734975; PMCID: PMC8569602.

Article  CAS  PubMed  Google Scholar 

Petrilli CM, Jones SA, Yang J, Rajagopalan H, O’Donnell L, Chernyak Y, Tobin KA, Cerfolio RJ, Francois F, Horwitz LI. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020;369:m1966. https://doi.org/10.1136/bmj.m1966. PMID: 32444366; PMCID: PMC7243801.

Bhargava A, Fukushima EA, Levine M, Zhao W, Tanveer F, Szpunar SM, Saravolatz L. Predictors for severe COVID-19 infection. Clin Infect Dis. 2020;71(8):1962–8. https://doi.org/10.1093/cid/ciaa674. PMID: 32472676; PMCID: PMC7314166.

Article  CAS  PubMed  Google Scholar 

Bhargava A, Szpunar SM, Sharma M, Fukushima EA, Hoshi S, Levine M, Gandhi N, Zhao W, Michael S, Tanveer F, Youssef D, Coyle M, Leonard J, Saravolatz L. Clinical features and risk factors for In-Hospital mortality from COVID-19 infection at a Tertiary Care Medical Center, at the onset of the US COVID-19 pandemic. J Intensive Care Med. 2021;36(6):711–8. Epub 2021 Mar 24. PMID: 33759606; PMCID: PMC7992101.

Article  PubMed  PubMed Central  Google Scholar 

Bhargava A, Sharma M, Akagi E, Szpunar SM, Saravolatz L. Predictors for in-hospital mortality from coronavirus disease 2019 (COVID-19) infection among adults aged 18–65 years. Infect Control Hosp Epidemiol. 2021;42(6):772–5. https://doi.org/10.1017/ice.2020.1390. Epub 2020 Dec 16. PMID: 33323138; PMCID: PMC8160493.

Article  CAS  PubMed  Google Scholar 

Bhargava A, Sharma M, Riederer K, Fukushima EA, Szpunar SM, Saravolatz L. Risk factors for In-hospital mortality from Coronavirus Disease 2019 Infection among Black Patients-An Urban Center Experience. Clin Infect Dis. 2021;73(11):e4005–11. https://doi.org/10.1093/cid/ciaa1468. PMID: 32986102; PMCID: PMC7543321.

Article  CAS  PubMed  Google Scholar 

Paliogiannis P, Mangoni AA, Cangemi M, Fois AG, Carru C, Zinellu A. Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis. Clin Exp Med. 2021;21(3):343–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rabbani G, Ahn SN, Review. Roles of human serum albumin in prediction, diagnoses and treatment of COVID-19. Int J Biol Macromol. 2021;193:948–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kato S, Chmielewski M, Honda H, Pecoits-Filho R, Matsuo S, Yuzawa Y, Tranaeus A, Stenvinkel P, Lindholm B. Aspects of immune dysfunction in end-stage renal disease. Clin J Am Soc Nephrol. 2008;3(5):1526–33. https://doi.org/10.2215/CJN.00950208. Epub 2008 Aug 13. PMID: 18701615; PMCID: PMC4571158.

Article  PubMed  PubMed Central  Google Scholar 

Sharma M, Bhargava A, Szpunar SM, Johnson LB, Saravolatz LD. Do risk factors at the time of hospital admission differ by sex for in-hospital mortality from coronavirus disease 2019 (COVID-19)? Antimicrob Steward Healthc Epidemiol. 2021;1(1):e55. https://doi.org/10.1017/ash.2021.223. PMID: 36168478; PMCID: PMC9495634.

Article  PubMed  PubMed Central  Google Scholar 

Malik P, Patel U, Mehta D, Patel N, Kelkar R, Akrmah M, Gabrilove JL, Sacks H. Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis. BMJ Evid Based Med. 2021;26(3):107–8. https://doi.org/10.1136/bmjebm-2020-111536. Epub 2020 Sep 15. PMID: 32934000; PMCID: PMC7493072.

Article  PubMed  Google Scholar 

Qeadan F, VanSant-Webb E, Tingey B, Rogers TN, Brooks E, Mensah NA, Winkfield KM, Saeed AI, English K, Rogers CR. Racial disparities in COVID-19 outcomes exist despite comparable Elixhauser comorbidity indices between blacks, hispanics, native americans, and whites. Sci Rep. 2021;11(1):8738. https://doi.org/10.1038/s41598-021-88308-2. PMID: 33888833; PMCID: PMC8062526.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gianfrancesco M, Hyrich KL, Al-Adely S, Carmona L, Danila MI, Gossec L, Izadi Z, Jacobsohn L, Katz P, Lawson-Tovey S, Mateus EF, Rush S, Schmajuk G, Simard J, Strangfeld A, Trupin L, Wysham KD, Bhana S, Costello W, Grainger R, Hausmann JS, Liew JW, Sirotich E, Sufka P, Wallace ZS, Yazdany J, Machado PM, Robinson PC. COVID-19 global Rheumatology Alliance. Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry. Ann Rheum Dis. 2020;79(7):859–66. https://doi.org/10.1136/annrheumdis-2020-217871. Epub 2020 May 29. PMID: 32471903; PMCID: PMC7299648.

Article  CAS