Rini BI, Campbell SC, Escudier B. Renal cell carcinoma. Lancet. 2009;373:1119–32.

Article  PubMed  CAS  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.

Article  PubMed  Google Scholar 

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin. 2021;71:7–33.

Article  PubMed  Google Scholar 

Capitanio U, Montorsi F. Renal cancer. Lancet. 2016;387:894–906.

Article  PubMed  Google Scholar 

Li T, Kang G, Wang T, Huang H. Tumor angiogenesis and anti-angiogenic gene therapy for cancer. Oncol Lett. 2018;16:687–702.

PubMed  PubMed Central  Google Scholar 

Qi S, Deng S, Lian Z, Yu K. Novel drugs with high efficacy against Tumor Angiogenesis. Int J Mol Sci 2022, 23.

Zheng W, Zhang S, Guo H, Chen X, Huang Z, Jiang S, Li M. Multi-omics analysis of tumor angiogenesis characteristics and potential epigenetic regulation mechanisms in renal clear cell carcinoma. Cell Commun Signal. 2021;19:39.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bhat TA, Singh RP. Tumor angiogenesis–a potential target in cancer chemoprevention. Food Chem Toxicol. 2008;46:1334–45.

Article  PubMed  CAS  Google Scholar 

Shibuya M. Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases. J Biochem. 2013;153:13–9.

Article  PubMed  CAS  Google Scholar 

Chen Y, Lu Z, Qi C, Yu C, Li Y, Huan W, Wang R, Luo W, Shen D, Ding L, et al. N(6)-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma. Mol Cancer. 2022;21:111.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Guo F, Liu J, Han X, Zhang X, Lin T, Wang Y, Bai J, Han J. FBXO22 suppresses metastasis in human renal cell Carcinoma via Inhibiting MMP-9-Mediated Migration and Invasion and VEGF-Mediated angiogenesis. Int J Biol Sci. 2019;15:647–56.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xu HF, Chen L, Liu XD, Zhan YH, Zhang HH, Li Q, Wu B. Targeting EGFL7 expression through RNA interference suppresses renal cell carcinoma growth by inhibiting angiogenesis. Asian Pac J Cancer Prev. 2014;15:3045–50.

Article  PubMed  Google Scholar 

Suzuki M, Saito-Adachi M, Arai Y, Fujiwara Y, Takai E, Shibata S, Seki M, Rokutan H, Maeda D, Horie M, et al. E74-Like factor 3 is a Key Regulator of Epithelial Integrity and Immune Response genes in biliary Tract Cancer. Cancer Res. 2021;81:489–500.

Article  PubMed  CAS  Google Scholar 

Zhou M, Ni J, Huang P, Liu X. Generation of a doxycycline-inducible ETV2 expression cell line using PiggyBac transposase system. Stem Cell Res. 2023;66:102985.

Article  PubMed  CAS  Google Scholar 

Oliver JR, Kushwah R, Hu J. Multiple roles of the epithelium-specific ETS transcription factor, ESE-1, in development and disease. Lab Invest. 2012;92:320–30.

Article  PubMed  CAS  Google Scholar 

Yao B, Zhao J, Li Y, Li H, Hu Z, Pan P, Zhang Y, Du E, Liu R, Xu Y. Elf5 inhibits TGF-β-driven epithelial-mesenchymal transition in prostate cancer by repressing SMAD3 activation. Prostate. 2015;75:872–82.

Article  PubMed  CAS  Google Scholar 

Singh S, Kumar S, Srivastava RK, Nandi A, Thacker G, Murali H, Kim S, Baldeon M, Tobias J, Blanco MA, et al. Loss of ELF5-FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling. Nat Cell Biol. 2020;22:591–602.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang X, Lin J, Ma Y, Zhao J. Overexpression of E74-Like factor 5 (ELF5) inhibits Migration and Invasion of Ovarian Cancer cells. Med Sci Monit. 2019;25:856–65.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lapinskas EJ, Svobodova S, Davis ID, Cebon J, Hertzog PJ, Pritchard MA. The ets transcription factor ELF5 functions as a tumor suppressor in the kidney. Twin Res Hum Genet. 2011;14:316–22.

Article  PubMed  Google Scholar 

Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell. 2012;150:12–27.

Article  PubMed  CAS  Google Scholar 

Meng H, Cao Y, Qin J, Song X, Zhang Q, Shi Y, Cao L. DNA methylation, its mediators and genome integrity. Int J Biol Sci. 2015;11:604–17.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li Y, Liang J, Hou P. Hypermethylation in gastric cancer. Clin Chim Acta. 2015;448:124–32.

Article  PubMed  CAS  Google Scholar 

Del Castillo Falconi VM, Torres-Arciga K, Matus-Ortega G, Díaz-Chávez J, Herrera LA. DNA methyltransferases: from evolution to clinical applications. Int J Mol Sci 2022, 23.

Putri JF, Widodo N, Sakamoto K, Kaul SC, Wadhwa R. Induction of senescence in cancer cells by 5’-Aza-2’-deoxycytidine: Bioinformatics and experimental insights to its targets. Comput Biol Chem. 2017;70:49–55.

Article  PubMed  CAS  Google Scholar 

Wu B, Cao X, Liang X, Zhang X, Zhang W, Sun G, Wang D. Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer. PLoS ONE. 2015;10:e0117510.

Article  PubMed  PubMed Central  Google Scholar 

Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis–correlation in invasive breast carcinoma. N Engl J Med. 1991;324:1–8.

Article  PubMed  CAS  Google Scholar 

Moore LD, Le T, Fan G. DNA methylation and its basic function. Neuropsychopharmacology. 2013;38:23–38.

Article  PubMed  CAS  Google Scholar 

Qian Y, Gong Y, Fan Z, Luo G, Huang Q, Deng S, Cheng H, Jin K, Ni Q, Yu X, Liu C. Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma. J Hematol Oncol. 2020;13:130.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Castro MG, Candolfi M, Kroeger K, King GD, Curtin JF, Yagiz K, Mineharu Y, Assi H, Wibowo M, Ghulam Muhammad AK, et al. Gene therapy and targeted toxins for glioma. Curr Gene Ther. 2011;11:155–80.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mao W, Wang K, Xu B, Zhang H, Sun S, Hu Q, Zhang L, Liu C, Chen S, Wu J, et al. ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma. Mol Cancer. 2021;20:142.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Qu X, Li Q, Tu S, Yang X, Wen W. ELF5 inhibits the proliferation and invasion of breast cancer cells by regulating CD24. Mol Biol Rep. 2021;48:5023–32.

Article  PubMed  CAS  Google Scholar 

Piggin CL, Roden DL, Gallego-Ortega D, Lee HJ, Oakes SR, Ormandy CJ. ELF5 isoform expression is tissue-specific and significantly altered in cancer. Breast Cancer Res. 2016;18:4.

Article  PubMed  PubMed Central  Google Scholar 

Viallard C, Larrivée B. Tumor angiogenesis and vascular normalization: alternative therapeutic targets. Angiogenesis. 2017;20:409–26.

Article  PubMed  CAS  Google Scholar 

Claesson-Welsh L, Welsh M. VEGFA and tumour angiogenesis. J Intern Med. 2013;273:114–27.

Article  PubMed  CAS  Google Scholar 

Mahmood N, Rabbani SA. Targeting DNA hypomethylation in malignancy by epigenetic therapies. Adv Exp Med Biol. 2019;1164:179–96.

Article  PubMed  CAS  Google Scholar 

Joosten SC, Smits KM, Aarts MJ, Melotte V, Koch A, Tjan-Heijnen VC, van Engeland M. Epigenetics in renal cell cancer: mechanisms and clinical applications. Nat Rev Urol. 2018;15:430–51.

Article  PubMed  CAS  Google Scholar 

Lyko F. The DNA methyltransferase family: a versatile toolkit for epigenetic regulation. Nat Rev Genet. 2018;19:81–92.

Article  PubMed  CAS  Google Scholar 

Hashimoto H, Vertino PM, Cheng X. Molecular coupling of DNA methylation and histone methylation. Epigenomics. 2010;2:657–69.

Article