Abd Alla, J., Langer, A., Wolf, S., Fu, X., Rageh, M. A., & Quitterer, U. (2023). BBLN triggers CAMK2D pathology in mice under cardiac pressure overload and potentially in unrepaired hearts with tetralogy of Fallot. Nature Cardiovascular Research, 2(11), 1044–1059. https://doi.org/10.1038/s44161-023-00351-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alessi, M.-C., & Juhan-Vague, I. (2006). PAI-1 and the metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(10), 2200–2207. https://doi.org/10.1161/01.ATV.0000242905.41404.68

Article  CAS  PubMed  Google Scholar 

Amini, H., Knepp, B., Rodriguez, F., Jickling, G. C., Hull, H., Carmona-Mora, P., Bushnell, C., Ander, B. P., Sharp, F. R., & Stamova, B. (2023). Early peripheral blood gene expression associated with good and poor 90-day ischemic stroke outcomes. Journal of Neuroinflammation, 20(1), 13. https://doi.org/10.1186/s12974-022-02680-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aso, Y. (2007). Plasminogen activator inhibitor (PAI)-1 in vascular inflammation and thrombosis. Frontiers in Bioscience-Landmark, 12(8), Article 8. https://doi.org/10.2741/2285

Article  Google Scholar 

Belykh, A. E., Soldatov, V. O., Stetskaya, T. A., Kobzeva, K. A., Soldatova, M. O., Polonikov, A. V., Deykin, A. V., Churnosov, M. I., Freidin, M. B., & Bushueva, O. Y. (2023). Polymorphism of SERF2, the gene encoding a heat-resistant obscure (Hero) protein with chaperone activity, is a novel link in ischemic stroke. IBRO Neuroscience Reports, 14, 453–461. https://doi.org/10.1016/j.ibneur.2023.05.004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Doeppner, T. R., Doehring, M., Kaltwasser, B., Majid, A., Lin, F., Bähr, M., Kilic, E., & Hermann, D. M. (2017). Ischemic post-conditioning induces post-stroke neuroprotection via Hsp70-mediated proteasome inhibition and facilitates neural progenitor cell transplantation. Molecular Neurobiology, 54(8), 6061–6073. https://doi.org/10.1007/s12035-016-0137-3

Article  CAS  PubMed  Google Scholar 

Harrell Jr, F. E., & Harrell Jr, M. F. E. (2019). Package ‘hmisc.’ CRAN2018, 2019, 235–236.

Huang, Y., Ma, G., Xie, S., Wei, R., Liu, Y., Zeng, Y., Zhao, Y., Wang, Q., Yang, L., Huang, H., Hao, L., Zhao, X., Wang, H., Shen, W., Wong, S. S. C., Cao, J.-L., Tao, Y.-X., & Pan, Z.-Q. (2025). SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice. Nature Communications, 16(1), 7225. https://doi.org/10.1038/s41467-025-62565-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jickling, G. C., Ander, B. P., Zhan, X., Noblett, D., Stamova, B., & Liu, D. (2014). MicroRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets. PLoS ONE, 9(6), e99283.

Article  PubMed  PubMed Central  Google Scholar 

Jurcau, A., & Simion, A. (2022). Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: From pathophysiology to therapeutic strategies. International Journal of Molecular Sciences, 23(1), 1. https://doi.org/10.3390/ijms23010014

Article  CAS  Google Scholar 

Kobzeva, K. A., Shilenok, I. V., Belykh, A. E., Gurtovoy, D. E., Krapiva, A. B., Stetskaya, T. A., Bykanova, M. A., Mezhenskaya, A. A., Lysikova, E. A., Freidin, M. B., & Bushueva, O. Y. (2022). C9orf16 (BBLN) gene, encoding a member of Hero proteins, is a novel marker in ischemic stroke risk. Research Results in Biomedicine. https://doi.org/10.18413/2658-6533-2022-8-3-0-2

Article  Google Scholar 

Kobzeva, K. A., Soldatova, M. O., Stetskaya, T. A., Soldatov, V. O., Deykin, A. V., Freidin, M. B., Bykanova, M. A., Churnosov, M. I., Polonikov, A. V., & Bushueva, O. Y. (2023). Association between HSPA8 gene variants and ischemic stroke: A pilot study providing additional evidence for the role of heat shock proteins in disease pathogenesis. Genes, 14(6), 1171. https://doi.org/10.3390/genes14061171

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lam, A. Y. W., Tomari, Y., & Tsuboyama, K. (2025). No structure, no problem: Protein stabilization by Hero proteins and other chaperone-like IDPs. Biochimica Et Biophysica Acta, 1869(6), Article 130786. https://doi.org/10.1016/j.bbagen.2025.130786

Article  CAS  PubMed  Google Scholar 

Lam, A. Y. W., Tsuboyama, K., Tadakuma, H., & Tomari, Y. (2024). DNAJA2 and Hero11 mediate similar conformational extension and aggregation suppression of TDP-43. RNA. https://doi.org/10.1261/rna.080165.124

Article  PubMed  Google Scholar 

Livak, K. J., & Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods, 25(4), 402–408. https://doi.org/10.1006/meth.2001.1262

Article  CAS  PubMed  Google Scholar 

Morimoto, E., Tsuboyama, K., & Tomari, Y. (2022). Fusion with heat-resistant obscure (Hero) proteins have the potential to improve the molecular property of recombinant proteins. PLoS ONE, 17(6), Article e0270097. https://doi.org/10.1371/journal.pone.0270097

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogle, D., & Ogle, M. D. (2017). Package ‘fsa.’ Cran Repos, 1–206.

Qin, C., Yang, S., Chu, Y.-H., Zhang, H., Pang, X.-W., Chen, L., Zhou, L.-Q., Chen, M., Tian, D.-S., & Wang, W. (2022). Signaling pathways involved in ischemic stroke: Molecular mechanisms and therapeutic interventions. Signal Transduction and Targeted Therapy, 7(1), 1. https://doi.org/10.1038/s41392-022-01064-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shilenok, I., Kobzeva, K., Deykin, A., Pokrovsky, V., Patrakhanov, E., & Bushueva, O. (2024a). Obesity and environmental risk factors significantly modify the association between ischemic stroke and the hero chaperone C19orf53. Life, 14(9), Article Article 9. https://doi.org/10.3390/life14091158

Article  CAS  Google Scholar 

Shilenok, I., Kobzeva, K., Soldatov, V., Deykin, A., & Bushueva, O. (2024b). C11orf58 (Hero20) gene polymorphism: Contribution to ischemic stroke risk and interactions with other heat-resistant obscure chaperones. Biomedicines, 12(11), Article Article 11. https://doi.org/10.3390/biomedicines12112603

Article  CAS  Google Scholar 

Shilenok, I., Kobzeva, K., Stetskaya, T., Freidin, M., Soldatova, M., Deykin, A., Soldatov, V., Churnosov, M., Polonikov, A., & Bushueva, O. (2023). SERPINE1 mRNA binding protein 1 is associated with ischemic stroke risk: A comprehensive molecular-genetic and bioinformatics analysis of SERBP1 SNPs. International Journal of Molecular Sciences, 24(10), 8716. https://doi.org/10.3390/ijms24108716

Article  CAS  PubMed  PubMed Central  Google Scholar 

Soldatov, V., Venediktov, A., Belykh, A., Piavchenko, G., Naimzada, M. D., Ogneva, N., Kartashkina, N., & Bushueva, O. (2024). Chaperones vs. oxidative stress in the pathobiology of ischemic stroke. Frontiers in Molecular Neuroscience. https://doi.org/10.3389/fnmol.2024.1513084

Article  PubMed  PubMed Central  Google Scholar 

Stetskaya, T. A., Kobzeva, K. A., Zaytsev, S. M., Shilenok, I. V., Komkova, G. V., Goryainova, N. V., & Bushueva, O. Y. (2024). HSPD1 gene polymorphism is associated with an increased risk of ischemic stroke in smokers. Research Results in Biomedicine, 10(2), 175–186. https://doi.org/10.18413/2658-6533-2024-10-2-0-1

Article  Google Scholar 

Tsang, C. K., Mi, Q., Su, G., Hwa Lee, G., Xie, X., D’Arcangelo, G., Huang, L., & Steven Zheng, X. F. (2023). Maf1 is an intrinsic suppressor against spontaneous neural repair and functional recovery after ischemic stroke. Journal of Advanced Research, 51, 73–90. https://doi.org/10.1016/j.jare.2022.11.007

Article  CAS  PubMed  Google Scholar 

Tsuboyama, K., Osaki, T., Matsuura-Suzuki, E., Kozuka-Hata, H., Okada, Y., Oyama, M., Ikeuchi, Y., Iwasaki, S., & Tomari, Y. (2020). A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation. PLoS Biology, 18(3), Article e3000632. https://doi.org/10.1371/journal.pbio.3000632

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, S., Li, X., Bi, Y., Yan, C., & Chen, Y. (2025). The impact of inflammation and iron metabolism on gene expression alterations in ischemic stroke: A bioinformatics approach. Scientific Reports, 15(1), 15233. https://doi.org/10.1038/s41598-025-00369-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, M., Liu, Q., Meng, H., Duan, H., Liu, X., Wu, J., Gao, F., Wang, S., Tan, R., & Yuan, J. (2024a). Ischemia-reperfusion injury: Molecular mechanisms and therapeutic targets. Signal Transduction and Targeted Therapy, 9(1), 1–39. https://doi.org/10.1038/s41392-023-01688-x

Article  CAS  Google Scholar 

Zhang, Q., Chen, W., Chen, S., Li, S., Wei, D., & He, W. (2019). Identification of key genes and upstream regulators in ischemic stroke. Brain and Behavior, 9(7), Article e01319. https://doi.org/10.1002/brb3.1319

Article  PubMed  PubMed Central