Fisetin Augments OEC Neuroprotection Through Modulating Neurotrophin/Cytokine Signaling and Activating PI3K/Akt/CREB Pathway in an In Vitro Neurodegenerative Injury

Ahuja, S., Wilson, J. R., Nori, S., Kotter, M., Druschel, C., Curt, A., & Fehlings, M. G. (2017). Traumatic spinal cord injury. Nature Reviewers Disease Primers, 3, 17018.

Article  Google Scholar 

Alizadeh, A., & Karimi-Abdolrezaee, S. (2016). Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury. The Journal of Physiology, 594(13), 3539–3552.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arai, Y., Watanabe, S., Kimira, M., Shimoi, K., Mochizuki, R., & Kinae, N. (2000). Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. Journal of Nutrition, 130(9), 2243–2250.

Article  CAS  PubMed  Google Scholar 

Assinck, P., Duncan, G., Hilton, B., Plemel, J., & Tetzlaff, W. (2017). Cell transplantation therapy for spinal cord injury. Nature Neuroscience, 20(5), 637–647.

Article  CAS  PubMed  Google Scholar 

Boyd, J., Doucette, R., & Kawaja, M. (2005). Defining the role of olfactory ensheathing cells in facilitating axon remyelination following damage to the spinal cord. FASEB Journal, 19(7), 694–703.

Article  CAS  PubMed  Google Scholar 

Chen, C., Yao, L., Cui, J., & Liu, B. (2018a). Fisetin protects against intracerebral hemorrhage-induced neuroinflammation in aged mice. Cerebrovascular Diseases, 45(3–4), 154–161.

Article  CAS  PubMed  Google Scholar 

Chen, L. Y., Kang, L. Q., Zhou, H. X., Gao, H. Q., Zhu, X. F., Xu, N., Yu, L., Wu, D. P., Xue, S. L., & Sun, A. N. (2020). Successful application of anti-CD19 CAR-T therapy with IL-6 knocking down to patients with central nervous system B-cell acute lymphocytic leukemia. Translational Oncology, 13(11), Article 100838.

Article  PubMed  PubMed Central  Google Scholar 

Chen, S., Ye, J., Chen, X., Shi, J., Wu, W., Lin, W., Lin, W., Li, Y., Fu, H., & Li, S. (2018b). Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3. Journal of Neuroinflammation, 15(1), 150.

Article  PubMed  PubMed Central  Google Scholar 

Chuang, J. Y., Chang, P. C., Shen, Y. C., Lin, C., Tsai, C. F., Chen, J. H., Yeh, W. L., & Wu, L. H. (2014). Regulatory effects of fisetin on microglial activation. Molecules, 19(7), 8820–8839.

Article  PubMed  PubMed Central  Google Scholar 

Cornblath, E. J., Robinson, J. L., Irwin, D. J., Lee, E. B., Lee, V. M., Trojanowski, J. Q., & Bassett, D. S. (2020). Defining and predicting transdiagnostic categories of neurodegenerative disease. Nature Biomedical Engineering, 4(8), 787–800.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding, H., Li, Y., Chen, S., Wen, Y., Zhang, S., Luo, E., Li, X., & Zhong, W. (2022). Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis-associated encephalopathy. CNS Neuroscience Therapeutics, 28(2), 247–258.

Article  CAS  PubMed  Google Scholar 

Elsallabi, O., Patruno, A., Pesce, M., Cataldi, A., Carradori, S., & Gallorini, M. (2022). Fisetin as a senotherapeutic agent: Biopharmaceutical properties and crosstalk between cell senescence and neuroprotection. Molecules, 27(3), 738.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evans, C., Cook, S. J., Coleman, M. P., & Gilley, J. (2013). MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling. PLoS ONE, 8(10), Article e76505.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gómez, R., Sánchez, M., Portela-Lomba, M., Ghotme, K., Barreto, G., & Sierra, J. (2018). Cell therapy for spinal cord injury with olfactory ensheathing glia cells (OECs). Glia, 66(7), 1267–1301.

Article  PubMed  Google Scholar 

Gu, J., Xu, H., Xu, Y. P., Liu, H. H., Lang, J. T., Chen, X. P., Xu, W. H., Deng, Y., & Fan, J. P. (2019). Olfactory ensheathing cells promote nerve regeneration and functional recovery after facial nerve defects. Neural Regeneration Reseach, 14(1), 124–131.

Article  Google Scholar 

Guo, J., Cao, G., Yang, G., Zhang, Y., Wang, Y., Song, W., Xu, Y., Ma, T., Liu, R., & Zhang, Q. (2020). Transplantation of activated olfactory ensheathing cells by curcumin strengthens regeneration and recovery of function after spinal cord injury in rats. Cytotherapy, 22(6), 301–312.

Article  CAS  PubMed  Google Scholar 

Hao, D. J., Liu, C., Zhang, L., Chen, B., Zhang, Q., Zhang, R., An, J., Zhao, J., Wu, M., Wang, Y., Simental, A., He, B. R., & Yang, H. (2017). Lipopolysaccharide and curcumin co-stimulation potentiates olfactory ensheathing cell phagocytosis via enhancing their activation. Neurotherapeutics, 14(2), 502–518.

Article  CAS  PubMed  Google Scholar 

Hassan, S. S. U., Samanta, S., Dash, R., Karpiński, T. M., Habibi, E., Sadiq, A., Ahmadi, A., & Bunagu, S. (2022). The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress. Frontiers in Pharmacology, 13, Article 1015835.

Article  PubMed  PubMed Central  Google Scholar 

He, B. R., Xie, S. T., Wu, M. M., Hao, D. J., & Yang, H. (2014). Phagocytic removal of neuronal debris by olfactory ensheathing cells enhances neuronal survival and neurite outgrowth via p38MAPK activity. Molecular Neurobiology, 49(3), 1501–1512.

Article  CAS  PubMed  Google Scholar 

He, J., Zhang, N., Zhu, Y., Jin, R., & Wu, F. (2021). MSC spheroids-loaded collagen hydrogels simultaneously promote neuronal differentiation and suppress inflammatory reaction through PI3K-Akt signaling pathway. Biomaterials, 265, Article 120448.

Article  CAS  PubMed  Google Scholar 

He, Y., Jiang, Y., Dong, L., Jiang, C., Zhang, L., Zhang, G., Yang, H., & Liu, J. (2023). The aOECs facilitate the neuronal differentiation of neural stem cells in the inflammatory microenvironment through up-regulation of bioactive factors and activation of Wnt3/β-catenin pathway. Moleclar Neurobiology, 60(2), 789–806.

Article  CAS  Google Scholar 

Hellenbrand, D., Quinn, C., Piper, Z., Morehouse, C. N., Fixel, J. A., & Hanna, A. S. (2021). Inflammation after spinal cord injury: A review of the critical timeline of signaling cues and cellular infiltration. Journal of Neuroinflammation, 18(1), 284.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang, C., Wang, X., Jiang, Y., Chen, Z., Zhang, Y., Hao, D., & Yang, H. (2023a). The anti-inflammation property of olfactory ensheathing cells in neural regeneration after spinal cord injury. Molecular Neurobiology, 59(10), 6447–6459.

Article  Google Scholar 

Jiang, Y., Guo, J., Tang, X., Wang, X., Hao, D., & Yang, H. (2022). The immunological roles of olfactory ensheathing cells in the treatment of spinal cord injury. Fronters in Immunology, 13, Article 881162.

Article  CAS  Google Scholar 

Jiang, Y., Tang, X., Deng, P., Jiang, C., He, Y., Hao, D., & Yang, H. (2023b). The neuroprotective role of fisetin in different neurological diseases: A systematic review. Molecular Neurobiology, 60(11), 6383–6394.

Article  CAS  PubMed  Google Scholar 

Johnson, D.A., Amirahmadi, S., Ward, C., Fabry, Z., Johnson, J.A. (2010). The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis. Toxicological Science, 114(2), 237–246.

Article  CAS  Google Scholar 

Khankan, R., Griffis, K., Haggerty-Skeans, J., Zhong, H., Roy, R. R., Edgerton, V. R., & Phelps, P. E. (2016). Olfactory ensheathing cell transplantation after a complete spinal cord transection mediates neuroprotective and immunomodulatory mechanisms to facilitate regeneration. The Journal Neuroscience, 36(23), 6269–6286.

Article  CAS  Google Scholar 

Kumar, R. M., Kumar, H., Bhatt, T., Jain, R., Panchal, K., Chaurasiya, A., & Jain, V. (2023). Fisetin in cancer: Attributes, developmental aspects, and anotherapeutics. Pharmaceuticals, 16(4), Article 196.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee, E., Hwang, I., Park, S., Hong, S., Hwang, B., Cho, Y., Son, J., & Yu, J. W. (2019). MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell Death and Differentiation, 26(2), 213–228.

Article  CAS  PubMed  Google Scholar 

Leung, J. Y., Chapman, J. A., Harris, J. A., Hale, D., Chung, R. S., West, A. K., & Chuah, M. I. (2008). Olfactory ensheathing cells are attracted to, and can endocytose, bacteria. Cellular and Molecular Life Sciences, 65(17), 2732–2739.

Article  CAS 

Comments (0)

No login
gif