Hypertension is a major driver of healthcare costs. Remote physiologic monitoring (RPM) combined with team-based chronic disease care management can improve blood pressure (BP) control and reduce risk of high-cost cardiovascular events.

To examine whether a pharmacist-led Digital Medicine program improves BP control, medication adherence, healthcare utilization, and cost of care among racial subpopulations of Medicare patients.

Retrospective single-institution observational study conducted between January 1, 2019, and October 15, 2023.

Medicare patients with hypertension enrolled in the intervention with ≥ 3 office-based BP readings within 6-month periods pre- and post-index event and their propensity score–matched controls.

Remote pharmacist-physician collaborative care employing RPM with lifestyle, medication, and care gap management.

Primary outcome was BP control (office-based). Secondary outcomes were medication adherence, service utilization, and cost of care. Outcomes were assessed at baseline, 3, 6, 12, and 18 months using difference-in-difference (DID) approach stratified by race.

A total of 5057 patients were included in the analysis. At baseline, Black patients had lower proportions of BP control. By 18 months, intervention compared to controls had higher rates of BP control (Digital-Medicine vs control, Proportion [95%CI]: Black, 0.761[0.728, 0.795] vs. 0.687 [0.654, 0.721]; White, 0.777 [0.755, 0.799] vs. 0.727 [0.704, 0.750]) and greater reductions in average SBP (DID, mmHg [95%CI]: Black, − 1.74 [− 3.18, − 0.29]; White, − 3.22 [− 4.22, − 2.23]) across racial subgroups. Differences in average DBP reductions were only significant for White patients (DID: Black, − 0.45 [− 1.23, 0.32]; White, − 1.48 [− 2.02, − 0.95]). Intervention compared to controls had higher odds of medication adherence, lower rates of inpatient and emergency department utilization, and no significant changes in primary care visits. Minimal changes in cost were observed.

Remote pharmacist-led care management increased BP control across racial subpopulations and improved medication adherence and acute care service utilization.