A novel cardioprotective mechanism of rosuvastatin: restoring PINK1/parkin-mediated mitophagy via SIRT1/FOXO1 activation in doxorubicin-induced cardiotoxicity

Capelôa T, Benyahia Z, Zampieri LX, Blackman M, Sonveaux P (2020) Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines. Semin Cell Dev Biol 98:181–191. https://doi.org/10.1016/j.semcdb.2019.05.006

Article  CAS  PubMed  Google Scholar 

Kalyanaraman B (2020) Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: have we been barking up the wrong tree? Redox Biol 29:101394. https://doi.org/10.1016/j.redox.2019.101394

Article  CAS  PubMed  Google Scholar 

Varela-López A, Battino M, Navarro-Hortal MD et al (2019) An update on the mechanisms related to cell death and toxicity of doxorubicin and the protective role of nutrients. Food Chem Toxicol 134:110834. https://doi.org/10.1016/j.fct.2019.110834

Article  PubMed  Google Scholar 

Shabalala S, Muller CJF, Louw J, Johnson R (2017) Polyphenols, autophagy and doxorubicin-induced cardiotoxicity. Life Sci 180:160–170. https://doi.org/10.1016/j.lfs.2017.05.003

Article  CAS  PubMed  Google Scholar 

Benjanuwattra J, Siri-Angkul N, Chattipakorn SC, Chattipakorn N (2020) Doxorubicin and its proarrhythmic effects: A comprehensive review of the evidence from experimental and clinical studies. Pharmacol Res 151:104542. https://doi.org/10.1016/j.phrs.2019.104542

Article  CAS  PubMed  Google Scholar 

Kim YA, Cho H, Lee N et al (2018) Doxorubicin-induced heart failure in cancer patients: a cohort study based on the Korean National health insurance database. Cancer Med 7:6084–6092. https://doi.org/10.1002/cam4.1886

Article  CAS  PubMed  PubMed Central  Google Scholar 

Armenian S, Bhatia S (2018) Predicting and preventing Anthracycline-Related cardiotoxicity. American society of clinical oncology educational book. 3–12. https://doi.org/10.1200/edbk_100015

Renu K, Pichiah T, Arunachalam S (2018) Molecular mechanism of doxorubicin-induced cardiomyopathy - an update. Eur J Pharmacol 818:241–253. https://doi.org/10.1016/j.ejphar.2017.10.043

Article  CAS  PubMed  Google Scholar 

Al Khafaji AT, Barakat AM, Shayyal AJ, Taan AA, Aboqader Al-Aouadi RF (2025) Managing doxorubicin cardiotoxicity: insights into molecular mechanisms and protective strategies. J Biochem Mol Toxicol 39:e70155. https://doi.org/10.1002/jbt.70155

Article  CAS  PubMed  Google Scholar 

Dirks-Naylor AJ (2013) The role of autophagy in doxorubicin-induced cardiotoxicity. Life Sci 93:913–916

Article  CAS  PubMed  Google Scholar 

Govender J, Loos B, Marais E, Engelbrecht AM (2014) Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin. J Pineal Res 57:367–380. https://doi.org/10.1111/jpi.12176

Article  CAS  PubMed  Google Scholar 

Koleini N, Kardami E (2017) Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity. Oncotarget 8:46663–46680. https://doi.org/10.18632/oncotarget.16944

Article  PubMed  PubMed Central  Google Scholar 

Bartlett JJ, Trivedi PC, Pulinilkunnil T (2017) Autophagic dysregulation in doxorubicin cardiomyopathy. J Mol Cell Cardiol 104:1–8. https://doi.org/10.1016/j.yjmcc.2017.01.007

Article  CAS  PubMed  Google Scholar 

Lin S, Xing H, Zang T, Ruan X, Wo L, He M (2018) Sirtuins in mitochondrial stress: indispensable helpers behind the scenes. Ageing Res Rev 44:22–32. https://doi.org/10.1016/j.arr.2018.03.006

Article  CAS  PubMed  Google Scholar 

Sala V, Della Sala A, Hirsch E, Ghigo A (2020) Signaling pathways underlying anthracycline cardiotoxicity. Antioxid Redox Signal 32:1098–1114. https://doi.org/10.1089/ars.2020.8019

Article  CAS  PubMed  Google Scholar 

Liu X, Zhang S, An L et al (2019) Loss of Rubicon ameliorates doxorubicin-induced cardiotoxicity through enhancement of mitochondrial quality. Int J Cardiol 296:129–135. https://doi.org/10.1016/j.ijcard.2019.07.074

Article  PubMed  Google Scholar 

Tang BL (2016) Sirt1 and the mitochondria. Mol Cells 39:87–95. https://doi.org/10.14348/molcells.2016.2318

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sengupta A, Molkentin JD, Paik JH, DePinho RA, Yutzey KE (2011) Foxo transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem 286:7468–7478. https://doi.org/10.1074/jbc.M110.179242

Article  CAS  PubMed  Google Scholar 

Sedlackova L, Korolchuk VI (2020) The crosstalk of NAD, ROS and autophagy in cellular health and ageing. 21:381–397. https://doi.org/10.1007/s10522-020-09864-0

Baldelli S, Aquilano K, Ciriolo MR (2014) PGC-1α buffers ROS-mediated removal of mitochondria during myogenesis. Cell Death Dis 5:e1515–e15. https://doi.org/10.1038/cddis.2014.458

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ni HM, Williams JA, Ding WX (2015) Mitochondrial dynamics and mitochondrial quality control. Redox Biol 4:6–13. https://doi.org/10.1016/j.redox.2014.11.006

Article  CAS  PubMed  Google Scholar 

Tan S, Wong E (2017) Mitophagy transcriptome: mechanistic insights into Polyphenol-Mediated mitophagy. 2017:9028435. https://doi.org/10.1155/2017/9028435

Lamark T, Svenning S, Johansen T (2017) Regulation of selective autophagy: the p62/SQSTM1 paradigm. Essays Biochem 61:609–624. https://doi.org/10.1042/ebc20170035

Article  PubMed  Google Scholar 

Zimmermann M, Reichert AS (2017) How to get rid of mitochondria: crosstalk and regulation of multiple mitophagy pathways. Biol Chem 399:29–45. https://doi.org/10.1515/hsz-2017-0206

Article  CAS  PubMed  Google Scholar 

Zhou H, Wang B, Yang YX et al (2019) Long noncoding RNAs in pathological cardiac remodeling: a review of the update literature. BioMed Res Int 2019(7159592). https://doi.org/10.1155/2019/7159592

Article  CAS  PubMed  Google Scholar 

Wang Y, Lu X, Wang X et al (2021) Atg7-based autophagy activation reverses doxorubicin-induced cardiotoxicity. Circ Res 129:e166–e82. https://doi.org/10.1161/circresaha.121.319104

Article  CAS  PubMed  PubMed Central  Google Scholar 

Collier JJ, Suomi F, Oláhová M, McWilliams TG, Taylor RW (2021) Emerging roles of ATG7 in human health and disease. EMBO Mol Med 13:e14824. https://doi.org/10.15252/emmm.202114824

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai F, Luis MAF, Lin X et al (2019) Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: preventive strategies and treatment. Mol Clin Oncol 11:15–23. https://doi.org/10.3892/mco.2019.1854

Article  CAS  PubMed  PubMed Central  Google Scholar 

Catanzaro MP, Weiner A, Kaminaris A et al (2019) Doxorubicin-induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy. FASEB J 33:11096–11108. https://doi.org/10.1096/fj.201802663R

Article  CAS  PubMed  PubMed Central  Google Scholar 

Osataphan N, Phrommintikul A, Chattipakorn SC, Chattipakorn N (2020) Effects of doxorubicin-induced cardiotoxicity on cardiac mitochondrial dynamics and mitochondrial function: insights for future interventions. J Cell Mol Med 24:6534–6557. https://doi.org/10.1111/jcmm.15305

Article  PubMed  PubMed Central  Google Scholar 

Ito Y, Maejima Y, Tamura N et al (2018) Synergistic effects of HMG-CoA reductase inhibitor and angio

Comments (0)

No login
gif