Guerreiro MP, Angelini L, Henriques HR, et al. Conversational agents for health and well-being across the life course: protocol for an evidence map. JMIR Res Protoc. 2021;10(9):e26680. https://doi.org/10.2196/26680.

Article  PubMed  PubMed Central  Google Scholar 

Weizenbaum J. ELIZA—a computer program for the study of natural language communication between man and machine. Commun ACM. 1966;9(1):36–45. https://doi.org/10.1145/365153.365168.

Article  Google Scholar 

Félix IB, Guerreiro MP, Cavaco A, et al. Development of a complex intervention to improve adherence to antidiabetic medication in older people using an anthropomorphic virtual assistant software. Front Pharmacol. 2019;10:680. https://doi.org/10.3389/fphar.2019.00680.

Article  PubMed  PubMed Central  Google Scholar 

S.A.R.A.H, a smart AI resource assistant for health. World Health Organization. Published 2024. https://www.who.int/campaigns/s-a-r-a-h. Accessed 1 Apr 2025.

Ramadhani C. Chatbots in pharmacy: a boon or a bane for patient care and pharmacy practice? Sci Pharm. 2023;2(3):1–23. https://doi.org/10.58920/sciphar02030001.

Article  Google Scholar 

Jongen G, Rijcken C. Your chef: the virtual pharmaceutical care assistant. In: Pharmaceutical care in digital revolution. 2023. (eds) Ardalan Mirzaei, Claudia Rijcken Publisher: Academic Press pp. 167–185. https://doi.org/10.1016/b978-0-443-13360-2.00003-4

Bates I, John C, Seegobin P, et al. An analysis of the global pharmacy workforce capacity trends from 2006 to 2012. Hum Resour Health. 2018;16(1):1–9. https://doi.org/10.1186/s12960-018-0267-y.

Article  Google Scholar 

Duede E, Dolan W, Bauer A, et al. Oil & Water? Diffusion of AI within and across scientific fields. arXiv (Cornell University) [Preprint]. Published online 23 May 2024. https://doi.org/10.48550/arxiv.2405.15828

International Classification of Health Interventions (ICHI). World Health Organization. Published 2020. https://www.who.int/standards/classifications/international-classification-of-health-interventions. Accessed 1 Apr 2025.

Martinengo L, Lin X, Jabir AI, et al. Conversational agents in health care: expert interviews to inform the definition, classification, and conceptual framework. J Med Internet Res. 2023;25:e50767. https://doi.org/10.2196/50767.

Article  PubMed  PubMed Central  Google Scholar 

Prayaga RB, Agrawal R, Nguyen B, et al. Impact of social determinants of health and demographics on refill requests by medicare patients using a conversational artificial intelligence text messaging solution: cross-sectional study. JMIR Mhealth Uhealth. 2019;7(11):e15771. https://doi.org/10.2196/15771.

Article  PubMed  PubMed Central  Google Scholar 

Gudala M, Ross MET, Mogalla S, et al. Benefits of, barriers to, and needs for an artificial intelligence-powered medication information voice chatbot for older adults: interview study with geriatrics experts. JMIR Aging. 2021;5(2):e32169. https://doi.org/10.2196/32169.

Article  Google Scholar 

Bickmore TW, Puskar K, Schlenk EA, et al. Maintaining reality: relational agents for antipsychotic medication adherence. Interact Comput. 2010;22(4):276–88. https://doi.org/10.1016/j.intcom.2010.02.001.

Article  Google Scholar 

Balsa J, Félix I, Cláudio AP, et al. Usability of an intelligent virtual assistant for promoting behavior change and self-care in older people with type 2 diabetes. J Med Syst. 2020;44(7):1–12. https://doi.org/10.1007/s10916-020-01583-w.

Article  Google Scholar 

Gong E, Baptista S, Russell A, et al. My diabetes coach, a mobile app-based interactive conversational agent to support type 2 diabetes self-management: randomized effectiveness-implementation trial. J Med Internet Res. 2020;22(11):e20322. https://doi.org/10.2196/20322.

Article  PubMed  PubMed Central  Google Scholar 

Anisha SA, Sen A, Bain C. Evaluating the potential and pitfalls of AI-powered conversational agents as human-like virtual health carers in the remote management of non-communicable diseases: a scoping review. J Med Internet Res. 2024;26:e56114. https://doi.org/10.2196/56114.

Article  PubMed  PubMed Central  Google Scholar 

Bramanti A, Corallo A, Clemente G, et al. Exploring the role of voice Assistants in Managing Noncommunicable Diseases: a systematic review on clinical, behavioral outcomes, quality of life, and user experiences. Healthcare. 2025;13(5):517. https://doi.org/10.3390/healthcare13050517.

Article  PubMed  PubMed Central  Google Scholar 

Curran GM, Landes SJ, McBain SA, et al. Reflections on 10 years of effectiveness-implementation hybrid studies. Front Health Serv. 2022;2:1053496. https://doi.org/10.3389/frhs.2022.1053496.

Article  PubMed  PubMed Central  Google Scholar 

Segur-Ferrer J, Moltó-Puigmartí C, Pastells-Peiró R, et al. Methodological frameworks and dimensions to be considered in Digital Health Technology Assessment: scoping review and thematic analysis. J Med Internet Res. 2024;26: e48694. https://doi.org/10.2196/48694.

Article  PubMed  PubMed Central  Google Scholar 

ORCHA Health. Digital Health Assessment Frameworks | Our products—ORCHA. ORCHA. Published 11 Jan 2024. https://orchahealth.com/our-products/assessment-frameworks/. Accessed 1 April 2025

Digital Technology Assessment Criteria (DTAC). NHS Transformation Directorate. https://transform.england.nhs.uk/key-tools-and-info/digital-technology-assessment-criteria-dtac/. Accessed 1 April 2025

Update of the standard for the assessment of digital services in the mHealth sector. Haute Autorité De Santé. https://www.has-sante.fr/jcms/p_3481960/en/update-of-the-standard-for-the-assessment-of-digital-services-in-the-mhealth-sector. Accessed 1 April 2025