Authors Bilal Ahmed Khanzada Liaquat University of Medical and Health Sciences, Jamshoro Israruddin Lashari Liaquat University of Medical and Health Sciences, Jamshoro Awais Bashir Peoples University of Medical and Health Sciences for Women, Nawabshah Komal Peoples University of Medical and Health Sciences for Women, Nawabshah Noor Nabi Siyal Peoples University of Medical and Health Sciences for Women, Nawabshah Mukhtiar Ahmed Abro Peoples University of Medical and Health Sciences for Women, Nawabshah DOI: https://doi.org/10.58397/qfgz5r09 Keywords: Epilepsy, Drug, Obesity, Resistance, pharmacological therapies Abstract

Objective: To assess the frequency and the association between the drugs resistant epilepsy (DRE) and obesity among patients at a tertiary care hospital in Pakistan
Methods: A descriptive cross-sectional study was conducted at the Department of Neurology, Liaquat University of Medical and Health Sciences, Hyderabad for 6 months post-approval of the project starting from March 2023, to September 2023. Data was obtained from 116 epilepsy patients after calculating the sample size, patients aged 18-60 years old patients of both genders were included, Pregnant women, children under the age of 18 years, and patients with a diagnosis of chronic liver disease and psychological disorders were excluded from the study. All the data was transferred to MS Excel and later on, assessed using the SPSS version 20.
Results: The data showed out of 116 patients the majority of patients with drug-resistant epilepsy were male i.e., 13.8%, however, 6.9% of females were seen with DRE cases the value of P was seen as 0.121. The BMI ranges were divided into 2 groups 19-30 and > 30. The more numbers of patients were among 12.1 % however the value of P =0.467. The mean ± standard deviation of age was 28.79±10.70 years. In the distribution of gender, 61 (52.6%) were male while 55 (47.4%) were female. Drug-resistant epilepsy (DRE) was observed in 24 (20.7%) patients of the study cohort. The remaining 92 (79.3%) of patients did not exhibit DRE. The median of ages was analyzed by applying statistics and seen 23.00 the 10.7 of std. deviation (p=0.225)
Conclusion: Drug-resistant epilepsy (DRE) was identified in 20.7% of patients, with no statistically significant association observed with gender, age, or BMI. Further studies with larger cohorts are recommended to explore obesity’s potential role in DRE prevalence and progression.

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