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E. Pesare, G. Maccagnano, G. Vicenti, I. Caruso, L. Di Gioia, M. Coviello, W. Ginestra, M. D’Aprile, C. Gallo, F. Giorgino, B. Moretti
Orthopaedic and Trauma Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, AOU Consorziale Policlinico, University of Bari “Aldo Moro”, Bari, Italy. michelecoviello91@gmail.com
OBJECTIVE: The diagnosis of euthyroid sick syndrome (ESS) in several diseases has been associated with poor outcomes, and proximal femur fractures are among the most common injuries in elderly patients, representing a leading cause of disability and mortality. There are no studies evaluating the mortality rate in patients with proximal femur fractures and ESS. The aim of our study was to evaluate a potential higher mortality rate in geriatric patients with proximal femur fracture and affected by ESS.
MATERIALS AND METHODS: In this proof-of-concept study, all patients older than 65 years with a diagnosis of proximal femur fracture were included. They were all treated surgically. The main exclusion criteria were acute cardio-pulmonary events, neoplastic diseases, and any thyroid or endocrine pathology.
RESULTS: Thirty-six patients who met our criteria were enrolled: 20 of them had a diagnosis of ESS (Group A), while 16 had a normal thyroid function as control (Group B). The mortality rate was evaluated at one month, three months, six, and twelve months after surgery. The survival analysis of enrolled patients showed a higher mortality rate in patients with ESS (p = 0.049) regardless of baseline comorbidities.
CONCLUSIONS: The ESS could be included among the predictive factors of all-cause mortality in geriatric patients with proximal femur fracture.
E. Pesare, G. Maccagnano, G. Vicenti, I. Caruso, L. Di Gioia, M. Coviello, W. Ginestra, M. D’Aprile, C. Gallo, F. Giorgino, B. Moretti
Euthyroid Sick Syndrome (ESS) in proximal femoral fractures: a proof-of-concept evaluation of postoperative outcomes in elderly patients
Eur Rev Med Pharmacol Sci
Year: 2025
Vol. 29 - N. 2
Pages: 67-73
DOI: 10.26355/eurrev_202502_37097
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