Non-invasive cerebral and spinal cord stimulation for motor and gait recovery in incomplete spinal cord injury: systematic review and meta-analysis

Fehlings MG, Tetreault LA, Aarabi B, Anderson P, Arnold PM, Brodke DS, et al. A clinical practice guideline for the management of patients with acute spinal cord injury: recommendations on the type and timing of rehabilitation. Glob Spine J. 2017;7(3 Suppl):231S-238S.

Article  Google Scholar 

Ditunno P, Patrick M, Stineman M, Ditunno J. Who wants to walk? Preferences for recovery after SCI: a longitudinal and cross-sectional study. Spinal Cord. 2008. https://doi.org/10.1038/sj.sc.3102172.

Article  PubMed  Google Scholar 

La Rosa G, Avola M, Di Gregorio T, Calabrò RS, Onesta MP. Gait recovery in spinal cord injury: a systematic review with metanalysis involving new rehabilitative technologies. Brain Sci. 2023;13(5):703.

Article  PubMed  PubMed Central  Google Scholar 

Harvey LA, Glinsky JV, Bowden JL. The effectiveness of 22 commonly administered physiotherapy interventions for people with spinal cord injury: a systematic review. Spinal Cord. 2016;54(11):914–23.

Article  PubMed  CAS  Google Scholar 

Takakusaki K. Neurophysiology of gait: from the spinal cord to the frontal lobe. Mov Disord. 2013;28(11):1483–91.

Article  PubMed  Google Scholar 

Eng JJ, Teasell R, Miller WC, Wolfe DL, Townson AF, Aubut JA, et al. Spinal cord injury rehabilitation evidence: methods of the SCIRE systematic review. Top Spinal Cord Inj Rehabil. 2007;13(1):1–10.

Article  PubMed  Google Scholar 

Yang FA, Chen SC, Chiu JF, Shih YC, Liou TH, Escorpizo R, et al. Body weight-supported gait training for patients with spinal cord injury: a network meta-analysis of randomised controlled trials. Sci Rep. 2022;12(1):19262.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wardhana DPW, Maliawan S, Mahadewa TGB, Rosyidi RM, Wiranata S. The impact of machine learning and robot-assisted gait training on spinal cord injury: a systematic review and meta-analysis. J Clin Med. 2023;12(23):7230.

Article  PubMed  PubMed Central  Google Scholar 

Stampacchia G, Gazzotti V, Olivieri M, Andrenelli E, Bonaiuti D, Calabro RS, et al. Gait robot-assisted rehabilitation in persons with spinal cord injury: a scoping review. NeuroRehabilitation. 2022;51(4):609–47.

PubMed  Google Scholar 

Thomaz SR, Cipriano G, Formiga MF, Fachin-Martins E, Cipriano GFB, Martins WR, et al. Effect of electrical stimulation on muscle atrophy and spasticity in patients with spinal cord injury—a systematic review with meta-analysis. Spinal Cord. 2019;57(4):258–66.

Article  PubMed  Google Scholar 

Morawietz C, Moffat F. Effects of locomotor training after incomplete spinal cord injury: a systematic review. Arch Phys Med Rehabil. 2013;94(11):2297–308.

Article  PubMed  Google Scholar 

Duffell LD, Brown GL, Mirbagheri MM. Interventions to reduce spasticity and improve function in people with chronic incomplete spinal cord injury: distinctions revealed by different analytical methods. Neurorehabil Neural Repair. 2015;29(6):566–76.

Article  PubMed  Google Scholar 

Veldema J. Non-invasive brain stimulation for improving gait, balance, and lower limbs motor function in stroke. J NeuroEng Rehabil. 2022. https://doi.org/10.1186/s12984-022-01062-y.

Article  PubMed  PubMed Central  Google Scholar 

Chen JM, Li XL, Pan QH, Yang Y, Xu SM, Xu JW. Effects of non-invasive brain stimulation on motor function after spinal cord injury: a systematic review and meta-analysis. J NeuroEng Rehabil. 2023;20(1):3.

Article  PubMed  PubMed Central  Google Scholar 

Megía García A, Serrano-Muñoz D, Taylor J, Avendaño-Coy J, Gómez-Soriano J. Transcutaneous spinal cord stimulation and motor rehabilitation in spinal cord injury: a systematic review. Neurorehabil Neural Repair. 2020;34(1):3–12.

Article  PubMed  Google Scholar 

Taylor C, McHugh C, Mockler D, Minogue C, Reilly RB, Fleming N. Transcutaneous spinal cord stimulation and motor responses in individuals with spinal cord injury: a methodological review. PLoS ONE. 2021;16(11): e0260166.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gunduz A, Rothwell J, Vidal J, Kumru H. Non-invasive brain stimulation to promote motor and functional recovery following spinal cord injury. Neural Regen Res. 2017;12(12):1933.

Article  PubMed  PubMed Central  Google Scholar 

Lefaucheur JP, André-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol. 2014;125(11):2150–206.

Article  PubMed  Google Scholar 

Rossini PM, Burke D, Chen R, Cohen LG, Daskalakis Z, Di Iorio R, et al. Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: basic principles and procedures for routine clinical and research application. An updated report from an IFCN Committee. Clin Neurophysiol. 2015;126(6):1071–107.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014–2018). Clin Neurophysiol. 2020;131(2):474–528.

Article  PubMed  Google Scholar 

Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol. 2000;527(3):633–9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lang N, Siebner HR, Ward NS, Lee L, Nitsche MA, Paulus W, et al. How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain? Eur J Neurosci. 2005;22(2):495–504.

Article  PubMed  PubMed Central  Google Scholar 

Lang N, Nitsche MA, Paulus W, Rothwell JC, Lemon RN. Effects of transcranial direct current stimulation over the human motor cortex on corticospinal and transcallosal excitability. Exp Brain Res. 2004;156(4):439–43.

Article  PubMed  CAS  Google Scholar 

Cogiamanian F, Vergari M, Pulecchi F, Marceglia S, Priori A. Effect of spinal transcutaneous direct current stimulation on somatosensory evoked potentials in humans. Clin Neurophysiol. 2008;119(11):2636–40.

Article  PubMed  Google Scholar 

Priori A, Ciocca M, Parazzini M, Vergari M, Ferrucci R. Transcranial cerebellar direct current stimulation and transcutaneous spinal cord direct current stimulation as innovative tools for neuroscientists. J Physiol. 2014;592(16):3345–69.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Guidetti M, Ferrucci R, Vergari M, Aglieco G, Naci A, Versace S, et al. Effects of transcutaneous spinal direct current stimulation (tsDCS) in patients with chronic pain: a clinical and neurophysiological study. Front Neurol. 2021;6(12): 695910.

Article  Google Scholar 

Bocci T, Marceglia S, Vergari M, Cognetto V, Sartucci F, Priori A. Transcutaneous spinal direct current stimulation modulates human corticospinal system excitability. J Neurophysiol. 2015. https://doi.org/10.1152/jn.00490.2014.

Article  PubMed  PubMed Central  Google Scholar 

Bocci T, Vannini B, Torzini A, Mazzatenta A, Vergari M, Cogiamanian F, et al. Cathodal transcutaneous spinal direct current stimulation (tsDCS) improves motor unit recruitment in healthy subjects. Neurosci Lett. 2014;22(578):75–9.

Article  Google Scholar 

Kumru H, Flores Á, Rodríguez Cañón M, Soriano I, García L, Vidal SJ. Estimulación no invasiva cerebral y medular para la recuperación motora y funcional tras una lesión medular. Rev Neurol. 2020;70(12):461.

Article  PubMed  CAS  Google Scholar 

de Lima FF, Silva CR, Kohn AF. Transcutaneous spinal direct current stimulation (tsDCS) does not affect postural sway of young and healthy subjects during quiet upright standing. PLoS ONE. 2022;17(4): e0267718.

Article  Google Scholar 

Rath M, Vette AH, Ramasubramaniam S, Li K, Burdick J, Edgerton VR, et al. Trunk stability enabled by noninvasive spinal electrical stimulation after spinal cord injury. J Neurotrauma. 2018;35(21):2540–53.

Article  PubMed  PubMed Central  Google Scholar 

Gad P, Gerasimenko Y, Zdunowski S, Turner A, Sayenko D, Lu DC, et al. Weight bearing over-ground stepping in an exoskeleton with non-invasive spinal cord neuromodulation after motor complete paraplegia. Front Neurosci. 2017;8(11):333.

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