Exposure of A2E to blue light promotes ferroptosis in the retinal pigment epithelium

Sparrow JR, Boulton M. RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res. 2005;80(5):595–606.

Article  CAS  PubMed  Google Scholar 

Sparrow JR, Kim SR, Wu Y. Experimental approaches to the study of A2E, a bisretinoid lipofuscin chromophore of retinal pigment epithelium. Method Mol Biol. 2010;652:315–27.

Article  CAS  Google Scholar 

Delori FC, Staurenghi G, Arend O, Dorey CK, Goger DG, Weiter JJ. In vivo measurement of lipofuscin in Stargardt’s disease-fundus flavimaculatus. Invest Ophthalmol Vis Sci. 1995;36:2327–31.

CAS  PubMed  Google Scholar 

Li J, Yao K, Yu X, Dong X, Gan L, Luo C, et al. Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells. J Biol Chem. 2013;288(50):35671–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu Y, Fishkin NE, Pande A, Pande J, Sparrow JR. Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease. J Biol Chem. 2009;284(30):20155–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cremers F, Lee W, Collin R, Allikmets R. Clinical spectrum, genetic complexity and therapeutic approaches for retinal disease caused by ABCA4 mutations. Prog Retin Eye Res. 2020;79: 100861.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allikmets R, Shroyer NF, Singh N, Seddon JM, Lewis RA, Bernstein PS, et al. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science. 1997;277:1805–7.

Article  CAS  PubMed  Google Scholar 

Allikmets R. Further evidence for an association of ABCR alleles with age-related macular degeneration. The international ABCR screening consortium. Am J Hum Genet. 2000;67(2):487–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang R, Wang LY, Wang YF, Wu CR, Lei CL, Wang MX, et al. Associations of the G1961E and D2177N variants in ABCA4 and the risk of age-related macular degeneration. Gene. 2015;567(1):51–7.

Article  CAS  PubMed  Google Scholar 

Maeda A, Maeda T, Imanishi Y, Kuksa V, Alekseev A, Bronson JD, et al. Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem. 2005;280(19):18822–32.

Article  CAS  PubMed  Google Scholar 

Maeda A, Maeda T, Golczak M, Palczewski K. Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem. 2008;283(39):26684–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Chen J, Liu Z, Li J, Yao K, Wu Y. Potential therapeutic agents against retinal diseases caused by aberrant metabolism of retinoids. Invest Ophthalmol Vis Sci. 2016;57(3):1017–30.

Article  CAS  PubMed  Google Scholar 

Maeda A, Golczak M, Maeda T, Palczewski K. Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Invest Ophthalmol Vis Sci. 2009;50(11):5435–43.

Article  PubMed  Google Scholar 

Sparrow JR, Parish CA, Hashimoto M, Nakanishi K. A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture. Invest Ophthalmol Vis Sci. 1999;40(12):2988–95.

CAS  PubMed  Google Scholar 

Holz FG, Schütt F, Kopitz J, Eldred GE, Kruse FE, Völcker HE, et al. Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci. 1999;40(3):737–43.

CAS  PubMed  Google Scholar 

Suter M, Remé C, Grimm C, Wenzel A, Jäättela M, Esser P, et al. Age-related macular degeneration. The lipofusion component N-retinyl-N-retinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells. J Biol Chem. 2000;275(50):39625–30.

Article  CAS  PubMed  Google Scholar 

Zhang J, Bai Y, Huang L, Qi Y, Zhang Q, Li S, et al. Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration. Cell Death Dis. 2015;6: e1972.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ben-Shabat S, Itagaki Y, Jockusch S, Sparrow JR, Turro NJ, Nakanishi K. Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement. Angew Chem Int Ed. 2002;41:814–7.

Article  CAS  Google Scholar 

Wu Y, Yanase E, Feng X, Siegel M, Sparrow J. Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc Natl Acad Sci USA. 2010;107(16):7275–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sparrow JR, Zhou J, Cai B. DNA is a target of the photodynamic effects elicited in A2E-laden RPE by blue-light illumination. Invest Ophthalmol Vis Sci. 2003;44:2245–51.

Article  PubMed  Google Scholar 

Sparrow JR, Zhou J, Ben-Shabat S, Vollmer H, Itagaki Y, Nakanishi K. Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE. Invest Ophthalmol Vis Sci. 2002;43(4):1222–7.

PubMed  Google Scholar 

Zhou J, Jang YP, Kim SR, Sparrow JR. Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci USA. 2006;103(44):16182–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marie M, Bigot K, Angebault C, Barrau C, Gondouin P, Pagan D, et al. Light action spectrum on oxidative stress and mitochondrial damage in A2E-loaded retinal pigment epithelium cells. Cell Death Dis. 2018;9(3):287.

Article  PubMed  PubMed Central  Google Scholar 

Liang D, Minikes AM, Jiang X. Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol Cell. 2022;82(12):2215–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sparrow JR, Cai B. Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl2. Invest Ophthalmol Vis Sci. 2001;42(6):1356–62.

CAS  PubMed  Google Scholar 

Pan C, Banerjee K, Lehmann GL, Almeida D, Hajjar KA, Benedicto I, et al. Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization. Proc Natl Acad Sci USA. 2021;118(47): e2100122118.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parish CA, Hashimoto M, Nakanishi K, Dillon J, Sparrow J. Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium. Proc Natl Acad Sci USA. 1998;95(25):14609–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao C, Cai B, Feng Y, Chen J, Wu Y, Zhuang J, et al. Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice. J Biol Chem. 2020;295(20):6958–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao L, He D, Liao C, Cai B, Chen C, Wang Y, et al. Repressing c-Jun N-terminal kinase signaling mitigates retinal pigment epithelium degeneration in mice with failure to clear all-trans-retinal. Exp Eye Res. 2022;214: 108877.

Article  CAS  P

Comments (0)

No login
gif