Fasting appetite-related gut hormone responses after weight loss induced by calorie restriction, exercise, or both in people with overweight or obesity: a meta‐analysis

Sarma S, Sockalingam S, Dash S. Obesity as a multisystem disease: trends in obesity rates and obesity-related complications. Diabetes Obes Metab. 2021;23:3–16.

Article  CAS  PubMed  Google Scholar 

NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet 2024;403:1027–50.

Anderson JW, Konz EC, Frederich RC, Wood CL. Long-term weight-loss maintenance: a meta-analysis of US studies. Am J Clin Nutr. 2001;74:579–84.

Article  CAS  PubMed  Google Scholar 

Busetto L, Bettini S, Makaronidis J, Roberts CA, Halford JCG, Batterham RL. Mechanisms of weight regain. Eur J Intern Med. 2021;93:3–7.

Article  CAS  PubMed  Google Scholar 

Ibrahim Abdalla MM. Ghrelin - Physiological Functions and Regulation. Eur Endocrinol. 2015;11:90–95.

PubMed  PubMed Central  Google Scholar 

Sobrino Crespo C, Perianes Cachero A, Puebla Jiménez L, Barrios V, Arilla Ferreiro E. Peptides and food intake. Front Endocrinol (Lausanne). 2014;5:1–13.

Article  Google Scholar 

Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000;407:908–13.

Article  PubMed  Google Scholar 

Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N. Engl J Med. 2003;349:941–8.

Article  CAS  PubMed  Google Scholar 

Gutzwiller JP, Göke B, Drewe J, Hildebrand P, Ketterer S, Handschin D, et al. Glucagon-like peptide-1: a potent regulator of food intake in humans. Gut 1999;44:81–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lieverse RJ, Jansen J, Masclee AAM, Lamers C. Satiety effects of cholecystokinin in humans. Gastroenterology 1994;106:1451–4.

Article  CAS  PubMed  Google Scholar 

Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, et al. Long-term persistence of hormonal adaptations to weight loss. N. Engl J Med. 2011;365:1597–604.

Article  CAS  PubMed  Google Scholar 

Holliday A, Blannin A. Appetite, food intake and gut hormone responses to intense aerobic exercise of different duration. J Endocrinol. 2017;235:193–205.

Article  CAS  PubMed  Google Scholar 

Hengist A, Sciarrillo CM, Guo J, Walter M, Hall KD. Gut-derived appetite hormones do not explain energy intake differences in humans following low-carbohydrate versus low-fat diets. Obesity (Silver Spring) 2024;32:1689–98.

Article  CAS  PubMed  Google Scholar 

Schubert MM, Desbrow B, Sabapathy S, Leveritt M. Acute exercise and subsequent energy intake. A meta-analysis. Appetite 2013;63:92–104.

Article  PubMed  Google Scholar 

King JA, Wasse LK, Ewens J, Crystallis K, Emmanuel J, Batterham RL, et al. Differential acylated ghrelin, peptide YY3-36, appetite, and food intake responses to equivalent energy deficits created by exercise and food restriction. J Clin Endocrinol Metab. 2011;96:1114–21.

Article  CAS  PubMed  Google Scholar 

Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med. 2011;17:1481–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chew CH, Choo QC, Lim WS, Lao KM, Wong SY, Chow XH. IL-6 possibly modulates ghrelin expression through MEK1/p90RSK signaling cascade in pancreatic cell lines. Cytokine 2014;70:34.

Article  Google Scholar 

Wu R, Dong W, Ji Y, Zhou M, Marini CP, Ravikumar TS, et al. Orexigenic hormone ghrelin attenuates local and remote organ injury after intestinal ischemia-reperfusion. PLoS One. 2008;3:e2026.

Article  PubMed  PubMed Central  Google Scholar 

Doucet E, Imbeault P, St-Pierre S, Alméras N, Mauriège P, Richard D, et al. Appetite after weight loss by energy restriction and a low-fat diet–exercise follow-up. Int J Obes. 2000;24:906–14.

Article  CAS  Google Scholar 

Nymo S, Coutinho SR, Eknes PH, Vestbostad I, Rehfeld JF, Truby H, et al. Investigation of the long-term sustainability of changes in appetite after weight loss. Int J Obes. 2018;42:1489–99.

Article  CAS  Google Scholar 

King NA, Caudwell PP, Hopkins M, Stubbs JR, Naslund E, Blundell JE. Dual-process action of exercise on appetite control: increase in orexigenic drive but improvement in meal-induced satiety23. Am J Clin Nutr. 2009;90:921–7.

Article  CAS  PubMed  Google Scholar 

Martins C, Kulseng B, King NA, Holst JJ, Blundell JE. The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat. J Clin Endocrinol Metab. 2010;95:1609–16.

Article  CAS  PubMed  Google Scholar 

Zhao X, Han Q, Gang X, Lv Y, Liu Y, Sun C, et al. The role of gut hormones in diet-induced weight change: a systematic review. Horm Metab Res. 2017;49:816–25.

Article  CAS  PubMed  Google Scholar 

Tacad DKM, Tovar AP, Richardson CE, Horn WF, Krishnan GP, Keim NL, et al. Satiety associated with calorie restriction and time-restricted feeding: peripheral hormones. Adv Nutr. 2022;13:792–820.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Almesbehi T, Harris L, McGarty A, Alqallaf S, Westrop S, Edwards CA, et al. Effects of exercise training programmes on fasting gastrointestinal appetite hormones in adults with overweight and obesity: A systematic review and meta-analysis. Appetite 2023;182:106424.

Article  PubMed  Google Scholar 

Hopkins M, Gibbons C, Blundell J. Fat-free mass and resting metabolic rate are determinants of energy intake: Implications for a theory of appetite control. Philos Trans R Soc Lond B Biol Sci. 2023;378:20220213.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grannell A, Kokkinos A, le Roux CW. Myokines in appetite control and energy balance. Muscles. 2022;1:26–47.

Article  Google Scholar 

Filigheddu N, Gnocchi VF, Coscia M, Cappelli M, Porporato PE, Taulli R, et al. Ghrelin and des-acyl ghrelin promote differentiation and fusion of C2C12 skeletal muscle cells. Mol Biol Cell. 2007;18:986–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Angelino E, Reano S, Bollo A, Ferrara M, De Feudis M, Sustova H, et al. Ghrelin knockout mice display defective skeletal muscle regeneration and impaired satellite cell self-renewal. Endocrine 2018;62:129–35.

Article  CAS  PubMed  Google Scholar 

Hagobian TA, Sharoff CG, Stephens BR, Wade GN, Silva JE, Chipkin SR, et al. Effects of exercise on energy-regulating hormones and appetite in men and women. Am J Physiol Regul Integr Comp Physiol. 2009;296:233–42.

Article  Google Scholar 

Ashtary-Larky D, Bagheri R, Abbasnezhad A, Tinsley GM, Alipour M, Wong A. Effects of gradual weight loss v. rapid weight loss on body composition and RMR: a systematic review and meta-analysis. Br J Nutr. 2020;124:1121–32.

Article  CAS  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71.

Article  PubMed  PubMed Central  Google Scholar 

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 2019;366:l4898.

Article  PubMed  Google Scholar 

Sterne JAC, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised st

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